A5052469128- Meta-analysis and systematic reviews
- Health Systems, Economic Evaluations, Quality of Life
- Ethics in Clinical Research
- Statistical Methods in Clinical Trials
- Otitis Media and Relapsing Polychondritis
- Advanced Causal Inference Techniques
- Biomedical Ethics and Regulation
- Vasculitis and related conditions
- Genomics and Rare Diseases
- Delphi Technique in Research
- Biomedical Text Mining and Ontologies
- Pharmaceutical industry and healthcare
- Artificial Intelligence in Healthcare and Education
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Education Practices and Challenges
- Motivation and Self-Concept in Sports
- Health and Medical Research Impacts
- Global Public Health Policies and Epidemiology
- Systemic Sclerosis and Related Diseases
- Health, Environment, Cognitive Aging
- Healthcare cost, quality, practices
- Academic Writing and Publishing
- Pharmaceutical Economics and Policy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Inserm
2015-2024
Université Paris Cité
2015-2024
Dynamique du noyau
2024
Université Paris Sciences et Lettres
2024
Centre National de la Recherche Scientifique
2024
Laboratoire de Sciences Cognitives et Psycholinguistique
2022-2024
École des hautes études en sciences sociales
2024
CY Cergy Paris Université
2024
Centre de Recherche Épidémiologie et Statistique
2016-2020
Sorbonne Paris Cité
2016-2020
<b>Objective</b> To examine how poor reporting and inadequate methods for key methodological features in randomised controlled trials (RCTs) have changed over the past three decades. <b>Design</b> Mapping of included Cochrane reviews. <b>Data sources</b> Data from RCTs all reviews published between March 2011 September 2014 an evaluation risk bias items: sequence generation, allocation concealment, blinding, incomplete outcome data. extraction</b> For each RCT, we...
Background Mapping the international landscape of clinical trials may inform global health research governance, but no large-scale data are available. Industry or non-industry sponsorship have a major influence in this mapping. We aimed to map industry- and non-industry–sponsored its evolution over time. Methods analyzed initiated between 2006 2013 registered WHO International Clinical Trials Registry Platform (ICTRP). mapped single-country by World Bank's income groups (industry- vs. non-...
To increase transparency in research, the International Committee of Medical Journal Editors required, 2005, prospective registration clinical trials as a condition to publication. However, many remain unregistered or retrospectively registered. We aimed assess association between trial and treatment effect estimates. This is meta-epidemiological study based on all Cochrane reviews published March 2011 September 2014 with meta-analyses binary outcome including three more randomised...
Inadequate planning, selective reporting, and incomplete reporting of outcomes in randomized controlled trials (RCTs) contribute to the problem waste research. We aimed describe such a examine what extent this could be avoided. This research-on-research study was based on RCTs included Cochrane reviews with summary findings (SoF) table. considered reported SoF tables as surrogates for important patients other decision makers. used three-step approach. (1) First, each review, we identified,...
Background: Evidence about the effect on meta-analysis results of including unpublished trials or those published in languages other than English is unclear discordant. Purpose: To compare treatment effects between and randomized controlled (RCTs) using a meta-epidemiologic approach. Data Sources: Cochrane reviews March 2011 January 2017 trial references cited reviews. Study Selection: RCTs included meta-analyses 3 more with binary efficacy outcome. Extraction: Trial characteristics were...
Objectives Assess the frequency and reasons for disagreements in risk of bias assessments randomised controlled trials (RCTs) included more than one Cochrane review. Design Research on research study, using cross-sectional design. Data sources 2796 reviews published between March 2011 September 2014. selection RCTs extraction Risk assessment support judgement five key items. synthesis For each item, we compared made review calculated proportion agreement. Two reviewers independently analysed...
Abstract Background Clinical trial registries may allow for producing a global mapping of health research. However, conditions are not described with standardized taxonomies in registries. Previous work analyzed clinical to improve the retrieval relevant trials patients. no previous has classified across diseases using taxonomy allowing comparison between research and burden diseases. We developed knowledge-based classifier studied registered towards categories injuries from Global Burden...
Introduction Teachers’ use of research has been increasingly advocated for in the past few decades, and some documented factors which positively or negatively influence teachers’ research. However, existing does not give relevant information to prioritize between different ways facilitate In addition, professionals working education may have divergent opinions about such priorities. This study therefore asks what are that most according teachers, teacher trainers, educational decision makers...
Post-marketing research in oncology has rarely been described. We aimed to characterize post-marketing trials for a consistent set of anticancer agents over long period. performed cross-sectional analysis registered at ClinicalTrials.gov through September 2014 novel approved by both the US Food and Drug Administration European Medicines Agency between 2005 2010. All relevant were classified according indication, primary outcome, starting date, sponsors, planned enrollment. Supplemental...
To characterise postmarketing studies for drugs that were newly approved by the US Food and Drug Administration European Medicines Agency.Cross-sectional analysis of registered in ClinicalTrials.gov until September 2014 all novel both regulators between 2005 2010. Regulatory documents from agencies used.All identified classified according to planned enrolment, funding, status geographical location, we determined whether studied originally indication.Overall, 69 2010 eligible inclusion. A...
Objective To provide a comprehensive overview of interventional clinical trials registered in international databases and planned conducted within the last 10 years patients with systemic sclerosis ( SS c). Methods We searched International Clinical Trials Registry Platform for all records on targeting c performed since September 2007. Two reviewers selected studies according to prespecified eligibility criteria. Information start date, country origin, funding sources, phase development,...
Publication bias and other reporting have been well documented for journal articles, but no study has evaluated the nature of results posted at ClinicalTrials.gov. We aimed to assess how many randomized controlled trials (RCTs) with ClinicalTrials.gov report statistically significant whether proportion differs when treatment effect estimate or p-value is posted.We searched in June 2015 all studies posted. included completed RCTs a superiority hypothesis considered first primary outcome For...
Learning, defined as the process of constructing meaning and developing competencies to act on it, is instrumental in helping individuals, communities, organizations tackle challenges. When these challenges increase complexity require domain knowledge from diverse areas expertise, it becomes difficult for single individuals address them. In this context, collective intelligence, a capacity groups people together solve problems using their knowledge, great importance. Technologies are both...
We examined whether drug-related characteristics-conditions, development, manufacturers, revenues-were associated with postmarketing research in terms of the number trials and total population to be enrolled. included 63 drugs, corresponding 3,867 approved indications. On multivariable analysis, both enrolled were expected length treatment (ratio means (RoM) = 2.35 RoM 8.65) patients pivotal (RoM 1.11 1.25 per thousand patients). The was increased for drugs surrogate endpoints 2.19),...
Abstract Background The analysis of the main features randomized controlled trials (RCTs) on ANCA-associated vasculitis (AAV) can inform future study design. Methods We searched within International Clinical Trials Registry Platform all registered RCTs AAV from October 2008 to December 2018. Two reviewers selected studies according pre-specified eligibility criteria. retrieved information including countries, funding, design, sample sizes, criteria, primary outcomes (POs), and treatments....
We conducted a mixed-methods observational study of the impact on educators ‘Teachers as Researchers’ programme in France 2020-21. A total 152 signed up and 112 joined at least one 118 workshops by 10 communities. examined changes educators’ sense efficacy, practice, collaboration work. found evidence positive effect teachers’ efficacy especially for teachers with high baseline measures, well practice among non-teachers. also qualitative that motivated
The objective of the study was to explore contextual factors associated with high or low risk-of-bias judgment in case incomplete unclear information reports.Research-on-research study, using matched case-control design, a sample 304 randomized controlled trials (RCTs) included two Cochrane reviews for which there disagreement on related report. A defined as an RCT judged at risk bias; control same risk. We used conditional logistic regression model analysis.Review authors being also were...
Background: Every day, millions of educators try out new practices to improve education. If a small proportion them made the observed effects their publicly available in database practice-based evidence, this could become promising source information for other better judge whether are worth own context. However, engaging producing trustworthy evidence and organising such so that others may easily find relevant cases is challenging.Objectives: We aimed at production publication trustworthy,...