J.F. Alexandra
A5076065355- Vasculitis and related conditions
- Infective Endocarditis Diagnosis and Management
- Bacterial Infections and Vaccines
- IgG4-Related and Inflammatory Diseases
- Cell Adhesion Molecules Research
- Systemic Lupus Erythematosus Research
- Pneumonia and Respiratory Infections
- Health, Medicine and Society
- Respiratory viral infections research
- Peripheral Artery Disease Management
- Aortic aneurysm repair treatments
- Infectious Aortic and Vascular Conditions
- Aortic Thrombus and Embolism
- Lysosomal Storage Disorders Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cellular transport and secretion
- Ocular Diseases and Behçet’s Syndrome
- Antimicrobial Resistance in Staphylococcus
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pharmaceutical industry and healthcare
- Autoimmune and Inflammatory Disorders Research
- Hemophilia Treatment and Research
- Carbohydrate Chemistry and Synthesis
- Cerebrovascular and Carotid Artery Diseases
- Atherosclerosis and Cardiovascular Diseases
Hôpital Bichat-Claude-Bernard
2015-2024
Assistance Publique – Hôpitaux de Paris
2018-2024
Université Paris Cité
2020-2023
Université Claude Bernard Lyon 1
2006-2023
Inserm
2021
<b><i>Background:</i></b> Cerebral complications are well-identified causes of morbidity and mortality in patients with infective endocarditis (IE). Few studies have analysed the impact brain magnetic resonance imaging (MRI) IE neurological manifestations. <b><i>Objectives:</i></b> The aims this study were to assess MRI contribution management manifestations compare cerebral CT findings. <b><i>Material Methods:</i></b>...
Background Aspecific scoring systems are used to predict the risk of death postsurgery in patients with infective endocarditis ( IE ). The purpose present study was both analyze factors for in‐hospital death, which complicates surgery , and create a mortality score based on results this analysis. Methods Results Outcomes 361 consecutive (mean age, 59.1±15.4 years) who had undergone 8 European centers cardiac were recorded prospectively, factor analysis (multivariable logistic regression)...
We aimed to describe patients with coexisting infective endocarditis (IE) and bacterial meningitis (BM). merged two large prospective cohorts, an IE cohort a BM cohort, only cases of definite community-acquired meningitis. compared who had concurrently only. Among the 1030 included patients, we identified 42 IE–BM (4.1%). Baseline characteristics were mostly similar those IE, but was predominant presentation at admission (39/42, 92.3%). Causative pathogens predominantly Streptococcus...
Purpose: This study aimed to evaluate the safety and efficacy of anakinra for severe refractory scleritis.Methods: Ten patients with (i.e. at least 2 ocular relapses per year despite treatment) [i.e. one disease modifying antirheumatic drugs (DMARDS)] scleritis were treated (100 mg/day subcutaneously). Scleritis was associated inflammatory systemic diseases in 60% cases. The remission rate defined primary outcome.Results: Ninety percent complete responders a mean follow-up 19.4 months after...
Abstract Background Increased access to heart valves through early surgery and progress in molecular microbiology have reduced the proportion of infective endocarditis (IE) with no microbiological documentation increased IE associated unusual microorganisms. Methods We performed an ancillary study a large prospective population-based survey on IE. Unusual-microorganism was defined as definite (Duke-Li criteria) due microorganisms other than streptococci, staphylococci, or enterococci....
Abstract Inhaled corticosteroids (ICS) have been associated with increased risk of pneumonia. Their impact on respiratory virus infections is unclear. We performed a post-hoc analysis the FLUVAC cohort, multicenter prospective cohort study adults hospitalized influenza-like illness (ILI) during six consecutive influenza seasons (2012–2018). All patients were tested for infection by multiplex PCR nasopharyngeal swabs and/or bronchoalveolar lavage. Risk factors identified logistic regression...
Tuberculous meningoencephalitis was diagnosed in a 33-year-old HIV-negative patient. CSF culture positive for drug-susceptible Mycobacterium tuberculosis and antituberculous therapy associated with steroids started. After 3 months, brain MRI showed worsening of the basal meningeal enhancement patient complained new headaches. analysis demonstrated pleocytosis (100 cells/mm3), an increased protein count (2,580 mg/dL); viral panel were negative. The considered due to immune reconstitution...
<h3>Background:</h3> Steroids and anti-IL6 biotherapy are highly effective in obtaining remission patients with giant cell arteritis (GCA) but the risk of relapses remains high. <h3>Objectives:</h3> We aimed to identify predictors relapse GCA. <h3>Methods:</h3> All consecutive admitted a new diagnosis GCA - according 2022 ACR/EULAR classification criteria between January 2011 December 2021 were eligible for this study. The primary outcome was rate over 36-months follow up. Factors associated...
Conflict of interests (COIs) adversely affect the integrity science and public health. The role medical schools in teaching management COIs has been highlighted by publication an annual evaluation American based on their policies Medical Student Association (AMSA). A deontological charter was adopted French 2018 but its impact COI comprehension students effects prevention were not evaluated.A 10-item direct survey conducted among about 1000 Paris-Cité University order to investigate respect...