A5101404966- Gut microbiota and health
- Diet and metabolism studies
- Pharmacological Effects of Natural Compounds
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Diverse Approaches in Healthcare and Education Studies
- Neurological Disease Mechanisms and Treatments
- Nutritional Studies and Diet
- Healthcare and Venom Research
- Inflammasome and immune disorders
- Neurogenesis and neuroplasticity mechanisms
- Vascular Malformations and Hemangiomas
- Gastrointestinal Tumor Research and Treatment
- Nutrition, Health and Food Behavior
- Cancer therapeutics and mechanisms
- Diverse Topics in Contemporary Research
- Ginseng Biological Effects and Applications
- Retinal Imaging and Analysis
- Wnt/β-catenin signaling in development and cancer
- Cutaneous lymphoproliferative disorders research
- Viral-associated cancers and disorders
- Phagocytosis and Immune Regulation
- Tourism, Volunteerism, and Development
- Neurofibromatosis and Schwannoma Cases
- Synthetic Organic Chemistry Methods
Yonsei University
2013-2024
Bio-Medical Science (South Korea)
2022-2023
Chosun University Hospital
2021-2023
Korea Institute of Science and Technology
2019-2023
Korea University of Science and Technology
2022-2023
RELX Group (Netherlands)
2022-2023
Rural Development Administration
2016-2023
Korea National Institute of Health
2023
Daejeon University
2022
Konyang University
2019
Abstract WNT signaling activation in colorectal cancers (CRCs) occurs through APC inactivation or β-catenin mutations. Both processes promote nuclear accumulation, which up-regulates epithelial-to-mesenchymal transition (EMT). We investigated localization, transcriptome, and phenotypic differences of HCT116 cells containing a wild-type (HCT116-WT) mutant allele (HCT116-MT), parental with both WT alleles (HCT116-P). then analyzed expression associated phenotypes CRC tissues. Wild-type showed...
Leaky gut symptoms and inflammatory bowel disease (IBD) are associated with damaged intestinal mucosa, permeability dysfunction by epithelial cell cytoskeleton contraction, disrupted intercellular tight junction (TJ) protein expression, abnormal immune responses intractable diseases.We evaluated the effects of schisandrin C, a dibenzocyclooctadiene lignan from Schisandra chinensis, on inflammation in mimetic systems: cultured cells, organoids, Caenorhabditis elegans model.Schisandrin C was...
We investigated associations of habitual dietary intake with the taxonomic composition and diversity human gut microbiota in 222 Koreans aged 18-58 years a cross-sectional study. Gut data were obtained by 16S rRNA gene sequencing on DNA extracted from fecal samples. The diet for previous year was assessed food frequency questionnaire. After multivariable adjustment, several groups including vegetables, fermented legumes, dairy products, processed meat, non-alcoholic beverages associated...
Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. Here, effects of 80 % ethanol extracts Salvia plebeia R. Br. (SE) on induced inflammatory response were investigated. inhibited production pro-inflammatory cytokines, such as TNF-α IL-6, well nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. NO cytokine was suppressed more effectively by SE aerial parts (SE-A) than roots (SE-R) S. plebeia. In BEAS-2B cells, both SE-A SE-R...
To compare the effectiveness of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment for pachychoroid neovasculopathy and neovascular age-related macular degeneration (AMD).Twenty-two eyes with 183 AMD were retrospectively included analysis. All patients naive received an initial series 3 monthly loading injections anti-VEGF, followed by further as required. The visual anatomical outcomes after evaluated at 12 months from baseline.The group showed a significant...
Diet has a profound impact on the progression of metabolic syndrome (MetS) into various diseases. The gut microbiota could modulate effect diet health. We examined whether dietary patterns related to MetS differed according microbial enterotypes among 348 Korean adults aged 18–60 years recruited between 2018∼2021 in cross-sectional study. enterotype each participant was identified based 16S rRNA data. main pattern predicting (MetS-DP) derived using reduced-rank regression (RRR) models. In...
The treatment of atopic dermatitis (AD) is challenging due to its complex etiology. From epidermal disruption chronic inflammation, various cells and inflammatory pathways contribute the progression AD. As with immunosuppressants, general inhibition can be effective, but this approach not suitable for long-term side effects. This study aimed identify a plant extract (PE) anti-inflammatory effects on multiple cell types involved in AD development provide relevant mechanistic evidence....
Gastrointestinal stromal tumors (GISTs) frequently show KIT mutations, accompanied by overexpression and aberrant localization of mutant (MT-KIT). As previously established multiple studies, including ours, we confirmed that MT-KIT initiates downstream signaling in the Golgi complex. Basic leucine zipper nuclear factor 1 (BLZF1) was identified as a novel MT-KIT-binding partner tethers to Sustained activation activated transcription 6 (ATF6), which belongs unfolded protein response (UPR)...
Objectives: Heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 has been identified as a target antigen of anti-endothelial cell immunglobulin (Ig)A antibodies in patients with Behçet’s disease (BD). The aim was to investigate the effects sera from BD and Streptococcus sanguis on subcellular expression hnRNP human dermal microvascular endothelial cells (HDMECs).Method: healthy controls (HC) well cultured S. were used stimulate HDMECs. Subcellular fractions obtained stimulated HDMECs...
Chronic cerebral hypoperfusion affects early and mature neurons in the subventricular zone (SVZ) cortex. Herein, we investigated effects of insulin-like growth factor-1 (IGF-1), a neurogenesis-promoting agent, on these regions periventricular leucomalacia (PVL) model rats.Following right carotid artery ligation, rats were placed hypoxia chamber injected with recombinant IGF-1 (0.1 1 μg/μl). Their brain sections immunohistochemically analysed using anti-nestin anti-NeuN antibodies.The numbers...
Precursor B-cell lymphoblastic lymphoma (B-LBL) is an uncommon high-grade neoplasm of immature B cells. It occurs predominantly in childhood with extranodal involvement such as skin and bone. Therefore, primary cutaneous elderly adults a very rare manifestation B-LBL. Here, we report 78-year-old man B-LBL presenting single lesion which was immunohistochemically positive for leukocyte common antigen (LCA), CD79a, paired box 5 (PAX5), cell lymphoma-2 (bcl-2), terminal deoxynucleotidyl...
Background/Aim: Neurogenesis is an important process in the recovery from neurological damage caused by ischemic lesions. Endogenous neurogenesis insufficient to restore neuronal following cerebral ischemia. Dexmedetomidine (DEX) exerts neuroprotective effects against ischemia and ischemia/reperfusion injury. DEX promotes neurogenesis, including proliferation maturation hippocampus. In a previous study, we showed that early increased 3 days after bilateral common carotid artery occlusion...
Abstract Background : Little is known of the relationship between Korean habitual diet and gut microbiota composition. We investigated associations dietary intake foods nutrients with taxonomic composition diversity in 222 adults aged 18-58 years a cross-sectional study. Gut microbial data were obtained by 16S rRNA gene sequencing bacterial DNA extracted from fecal samples. Habitual for previous year was collected validated food frequency questionnaire. Correlations intakes examined...
Aging is a growing problem worldwide, and the prevalence mortality of arterial venous thromboembolism (VTE) are higher in elderly than young population. To address this issue, various anticoagulants have been used. However, no evidence can confirm that antithrombotic agents suitable for elderly. Therefore, study aims to investigate platelet proteome aged mice identify drug targets specific Based on analysis platelets from mice, 308 increased or decreased proteins were identified. Among these...