A5055223510- Cancer survivorship and care
- Nutrition and Health in Aging
- Cancer Treatment and Pharmacology
- Childhood Cancer Survivors' Quality of Life
- Colorectal Cancer Treatments and Studies
- Cancer-related cognitive impairment studies
- Palliative Care and End-of-Life Issues
- Nutritional Studies and Diet
- Health Systems, Economic Evaluations, Quality of Life
- Global Cancer Incidence and Screening
- Indoor Air Quality and Microbial Exposure
- Hepatocellular Carcinoma Treatment and Prognosis
- Chemotherapy-induced cardiotoxicity and mitigation
- Patient-Provider Communication in Healthcare
- Colorectal Cancer Screening and Detection
- Genomics and Rare Diseases
- Frailty in Older Adults
- Economic and Financial Impacts of Cancer
- Cancer Risks and Factors
- Diet and metabolism studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Smoking Behavior and Cessation
- Cancer Genomics and Diagnostics
- Colorectal Cancer Surgical Treatments
- Clinical practice guidelines implementation
Utrecht University
2008-2025
University Medical Center Utrecht
2016-2025
Oklahoma State University Center for Health Sciences
2016-2023
Heidelberg University
2020
University Hospital Heidelberg
2020
University Medical Center
2016
University Hospital and Clinics
2016
Meander Medisch Centrum
2015
Institut Català d'Oncologia
2015
Netherlands Comprehensive Cancer Organisation
2015
Purpose Fatigue is a common problem among colon cancer patients and typically increases during chemotherapy. Exercise chemotherapy might have beneficial effects on fatigue. To investigate the short- long-term of an exercise program in adjuvant treatment, Physical Activity During Cancer Treatment study was conducted. Methods In this multicenter randomized controlled trial, 33 undergoing (21 men 12 women) were randomly assigned to either group receiving 18-wk supervised (n = 17) or usual care...
As the resolution of coronavirus disease 2019 (COVID-19) crisis is unforeseeable, and/or a second wave infections may arrive in fall 2020, it important to evaluate patients' perspectives learn from this.To assess how Dutch patients with cancer perceive treatment and follow-up care (including experiences telephone video consultations [TC/VC]) well-being comparison norm population during COVID-19 crisis.Cross-sectional study participating Patient Reported Outcomes Following Initial Treatment...
Abstract Background Up to 60% of breast cancer patients treated with chemotherapy is confronted cognitive problems, which can have a significant impact on daily activities and quality life (QoL). We investigated whether exercise training improves cognition in chemotherapy-exposed 2–4 years after diagnosis. Methods Chemotherapy-exposed patients, both self-reported problems lower than expected performance neuropsychological tests, were randomized an or control group. The 6-month intervention...
The aim of this study was to longitudinally investigate dietary and lifestyle inflammation scores their interaction in relation risk colorectal cancer (CRC) recurrence all-cause mortality.
Physical inactivity and overweight are risk factors for postmenopausal breast cancer. The effect of physical activity may be partially mediated by concordant weight loss. We studied the on serum sex hormones, which known to associated with cancer risk, that is attributable exercise comparing randomly obtained equivalent loss following a hypocaloric diet only or mainly exercise. Overweight, insufficiently active women were randomised (N = 97), 98) control group 48). goal both interventions...
Despite the widely acknowledged benefit of exercise for patients with cancer, little evidence on optimal timing adverse effects cancer treatment is available.The aim this study was to determine whether an intervention initiated during chemotherapy superior after improving long-term cardiorespiratory fitness (peak oxygen uptake [VO2peak]).In prospective, randomized clinical trial, scheduled receive curative were a 24-week intervention, either (group A) or afterward B). The primary endpoint...
Objective: To conduct a randomized controlled trial and compare the effects on cancer survivors' quality of life in 12-week group-based multidisciplinary self-management rehabilitation program, combining physical training (twice weekly) cognitive-behavioral (once with those weekly). In addition, both interventions were compared no intervention. Methods: Participants (all types, medical treatment completed ≥3 months ago) randomly assigned to (n = 76) or 71). The nonintervention comparison...
We compared the effect of a 12-week group-based multidisciplinary self-management rehabilitation program, combining physical training (twice weekly) and cognitive-behavioral therapy (once with on cancer survivors' quality life over 1-year period.One hundred forty-seven survivors [48.8 +/- 10.9 years (mean SD), all types, medical treatment > or = 3 months ago] were randomly assigned to either (PT, n 71) plus (PT + CBT, 76). Quality activity levels measured before immediately after...
Objective Meta-analyses show that exercise interventions during cancer treatment reduce cancer-related fatigue. However, little is known about the cost-effectiveness of such interventions. Here we aim to assess 18-week physical activity (PACT) intervention for patients with breast and colon cancer. The PACT trial showed beneficial effects fatigue fitness. Design Cost-effectiveness analyses a 9-month time horizon (18 weeks 18 follow-up) within randomised controlled multicentre study. Setting...
The Trials within Cohorts (TwiCs) design is an alternative for pragmatic randomized controlled trials (RCTs) and might overcome disadvantages such as difficult recruitment, dropout after randomization to control, contamination. We investigated the applicability of TwiCs in exercise oncology study regarding recruitment process, representativeness sample, contamination, participation, dropout.The Utrecht cohort Multiple BREast cancer intervention studies Long-term evaLuAtion (UMBRELLA) Fit...
Abstract Background Many patients with metastatic breast cancer experience cancer- and treatment-related side effects that impair activities of daily living negatively affect the quality life. There is a need for interventions improve life by alleviating fatigue other during palliative treatment. Beneficial exercise have been observed in curative setting, but, to date, comparable evidence lacking. The aim this study assess structured individualized 9-month intervention on life, fatigue,...
Higher levels of physical activity are associated with a lower risk cardiovascular disease in the general population. Whether same holds for women who underwent treatment breast cancer is unclear.The aim this study was to evaluate association between typical week past 12 months and cardiac dysfunction survivors.We used data from cohort survivors were treated at ages 40 50 years (N = 559). The global longitudinal strain (GLS) left ventricular ejection fraction (LVEF) evaluated using both...
To date, there is no validated questionnaire to assess fear of movement in cancer survivors. We aim validate the modified Tampa scale kinesiophobia-fatigue (TSK-F) Dutch survivors participating a rehabilitation programme. first select optimal model for Subsequently, stability, internal consistency, and construct validity tested.A sample 658 programme was included. Out nine models derived chronic pain fatigue patients, TSK-F selected calibration (n1 = 329) using confirmatory factor analysis....
ObjectivesThe trials within cohorts (TwiCs) design aims to improve recruitment efficiency. We conducted the first TwiCs in radiation oncology and described efficiency of generalizability results.Study Design SettingIn two radiotherapy centers, patients with rectal cancer were asked participate a prospective cohort study provide broad consent for randomization patient-reported outcomes (PROs). Consenting who met trial criteria randomized directly after enrollment. The intervention arm was...
Shared decision making (SDM) for cancer treatment yields positive results. However, it appears that discussing essential topics SDM is not fully integrated into yet. Therefore, we aim to explore what extent discussion of therapy options, consequences, and personal priorities preferred perceived by (former) patients.An online questionnaire was distributed the Dutch Federation Cancer Patient Organisations among patients in 2018.Among 3785 patients, 3254 (86%) had discussed treatments with...
We assessed the effect of equivalent weight loss with or without exercise on (intra-) abdominal fat in postmenopausal women SHAPE-2 study.The study is a three-armed randomised controlled trial conducted 2012-2013 Netherlands. Postmenopausal overweight were randomized to diet (n = 97), plus 98) control group 48). Both intervention groups aimed for (6-7%) following calorie-restricted (diet group) partly supervised intensive programme (4 h per week) combined small caloric restriction (exercise...
Introduction Radical cystectomy (RC) is the standard treatment for patients with non-metastatic muscle-invasive bladder cancer, as well therapy refractory high-risk non-muscle invasive cancer. However, 50–65% of undergoing RC experience perioperative complications. The risk, severity and impact these complications associated a patient’s preoperative cardiorespiratory fitness, nutritional smoking status presence anxiety depression. There emerging evidence supporting multimodal prehabilitation...
For palliation of extrahepatic bile duct obstruction, self-expandable metal stents (SEMS) are superior to plastic in terms stent patency and occurrence dysfunction. We assessed health-related quality life (HRQoL) after placement investigate whether this also results a difference HRQoL between patients treated with or SEMS.This randomized multicenter trial included 219 who were receive (n=73) SEMS [uncovered (n=75) covered (n=71); n=146] placement. was two general questionnaires (EQ-5D-3L...