A5047299349- Cardiovascular Function and Risk Factors
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Cardiac Imaging and Diagnostics
- Vitamin C and Antioxidants Research
- Thermal Regulation in Medicine
- Endoplasmic Reticulum Stress and Disease
- Cardiac electrophysiology and arrhythmias
- Autophagy in Disease and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Mesenchymal stem cell research
- Diet and metabolism studies
- Pulmonary Hypertension Research and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Cardiac Valve Diseases and Treatments
German Institute of Human Nutrition
2018-2021
German Centre for Cardiovascular Research
2018-2021
Charité - Universitätsmedizin Berlin
2018-2019
Cancer cachexia represents a central obstacle in medical oncology as it is associated with poor therapy response and reduced overall survival. Systemic inflammation considered to be key driver of cancer cachexia; however, clinical studies anti-inflammatory drugs failed show distinct cachexia-inhibiting effects. To address this contradiction, we investigated the functional importance innate immune cells for hepatocellular carcinoma (HCC)-associated cachexia.A transgenic HCC mouse model was...
Background: Obesity is a risk factor for diseases including type 2 diabetes mellitus (T2DM) and cardiovascular disorders. Diabetes itself contributes to cardiac damage. Thus, studying events establishing therapeutic intervention in the period of T2DM onset manifestation are highest importance. Mitochondrial dysfunction one pathophysiological mechanisms leading impaired function. Methods: An adequate animal model pathophysiology New Zealand Obese (NZO) mouse. These mice were maintained on...
Cardiac remodeling and contractile dysfunction are leading causes in hypertrophy-associated heart failure (HF), increasing with a population’s rising age. A hallmark of aged diseased hearts is the accumulation modified proteins caused by an impaired autophagy-lysosomal-pathway. Although, autophagy inducer rapamycin has been described to exert cardioprotective effects, it remains be shown whether these effects can attributed improved cardiomyocyte contractility. In vivo hypertrophy was...
Echocardiography is the most commonly applied technique for non-invasive assessment of cardiac function in small animals. Manual tracing endocardial borders time consuming and varies with operator experience. Therefore, we aimed to evaluate a novel automated two-dimensional software algorithm (Auto2DE) animals compare it standard use manual 2D-echocardiographic (2DE). We hypothesized that Auto2DE will provide rapid robust data sets, which are agreement manually assessed animals.2DE were...
Background Degenerative aortic valve (AoV) disease and resulting stenosis are major clinical health problems. Murine models of rare, in a translational knowledge gap on underlying mechanisms, functional consequences, potential therapies. Naïve New Zealand obese (NZO) mice were recently found to have dramatic decline left ventricular (LV) function at early age. Therefore, we aimed identify the cause reduced LV NZO mice. Methods Results Cardiac pulmonary hemodynamics age‐matched C57BL/6J...
Abstract Cancer cachexia represents a central obstacle in medical oncology as it is associated with poor therapy response and reduced overall survival. Systemic inflammation considered to be key driver of cancer cachexia, however, clinical studies anti-inflammatory drugs failed show robust cachexia-inhibiting effect. To address this contradiction, we investigated the functional importance innate immune cells for hepatocellular carcinoma (HCC)-associated cachexia. end, used transgenic HCC...
Cancer cachexia represents a central obstacle in medical oncology as it is associated with poor therapy response and reduced overall survival. Systemic inflammation considered to be key driver of cancer cachexia, however, clinical studies anti-inflammatory drugs failed show distinct cachexia-inhibiting effects. To address this contradiction, we investigated the functional importance innate immune cells for hepatocellular carcinoma (HCC)-associated cachexia. end, used transgenic HCC mouse...