A5100454998- Genetic factors in colorectal cancer
- Spinal Dysraphism and Malformations
- Spinal Cord Injury Research
- Cancer Genomics and Diagnostics
- Mesenchymal stem cell research
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Sedative Agents
- Pain Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Trigeminal Neuralgia and Treatments
- Pain Management and Opioid Use
- Anesthesia and Pain Management
- DNA Repair Mechanisms
- S100 Proteins and Annexins
- Aortic Disease and Treatment Approaches
- SARS-CoV-2 detection and testing
- Advancements in Battery Materials
- Metal complexes synthesis and properties
- SARS-CoV-2 and COVID-19 Research
- Nausea and vomiting management
- Menopause: Health Impacts and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Colorectal Cancer Screening and Detection
- Phytoestrogen effects and research
Central South University
2015-2024
Second Xiangya Hospital of Central South University
2015-2024
Anhui University of Technology
2024
Jinan University
2023
Peking University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2022
National Clinical Research Center for Digestive Diseases
2022
China Astronaut Research and Training Center
2022
Peking Union Medical College Hospital
2013-2022
Wuxi Taihu Hospital
2021
BackgroundA novel variant of SARS-CoV-2, the Delta concern (VOC, also known as lineage B.1.617.2), is fast becoming dominant strain globally. We reported epidemiological, viral, and clinical characteristics hospitalized patients infected with VOC during local outbreak in Guangzhou, China.MethodsWe extracted epidemiological information pertaining to 159 cases across seven transmission generations between May 21 June 18, 2021. The whole chain was described. Kinetics viral load were compared a...
Abstract On May 17, 2016, after an expedited priority review, the U.S. Food and Drug Administration granted accelerated approval to nivolumab for treatment of patients with classical Hodgkin lymphoma (cHL) that has relapsed or progressed autologous hematopoietic stem cell transplantation (HSCT) post-transplantation brentuximab vedotin (BV). Nivolumab in cHL had been breakthrough therapy designation. Accelerated was based on two single-arm, multicenter trials adults cHL. In 95 progressive...
Ciprofol is a propofol analogue with improved pharmacokinetic properties. A multi-centre, non-inferiority trial was conducted to compare the deep sedation properties of ciprofol and margin 8% in patients undergoing gastroscopy colonoscopy. In total, 289 were randomly allocated for surgery (259 colonoscopy 30 gastroscopy) at 1:1 ratio be given intravenous injections (0.4 mg/kg) or (1.5 mg/kg). The primary outcome success rate defined as completion no need an alternative sedative >5 top up...
Demyelination contributes to the dysfunction after traumatic spinal cord injury (SCI). We explored whether combination of neurotrophic factors and transplantation adult rat oligodendrocyte precursor cells (OPCs) could enhance remyelination functional recovery SCI. Ciliary factor (CNTF) was most effective promote (OL) differentiation survival OPCs in vitro . were infected with retroviruses expressing enhanced green fluorescent protein (EGFP) or CNTF transplanted into contused thoracic 9 d...
Promotion of remyelination is an important therapeutic strategy to facilitate functional recovery after traumatic spinal cord injury (SCI). Transplantation neural stem cells (NSCs) or oligodendrocyte precursor (OPCs) has been used enhance SCI. However, the microenvironment in injured inhibitory for (OL) differentiation NSCs OPCs. Identifying signaling pathways that inhibit OL could lead new strategies and In present study, we show reactive astrocytes from rat their conditioned media adult...
Ciprofol is a new intravenous anesthetic agent similar to propofol that has the pharmacodynamic characteristics of rapid rate onset and recovery in pre-clinical experiments. The aims present clinical trials were compare efficacy safety ciprofol emulsion for sedation or general anesthesia during colonoscopy define optimal doses subsequent phase III trial.A IIa multi-center, open-label, non-randomized, positive control, dose-escalating study was performed determine recommended IIb dose (RP2D)...
Fiberoptic bronchoscopy is a complex procedure with the need for sufficient patient anesthesia/sedation while maintaining safety. This trial aimed to evaluate efficacy, safety, and pharmacokinetics of HSK3486 during fiberoptic bronchoscopy. multicenter, double-blind, randomized, non-inferiority, parallel-group phase 3 was conducted in patients who underwent Patients randomly received 0.4 mg/kg (N = 134) or propofol 2.0 133). The primary efficacy endpoint successful rate bronchoscopy,...
Abstract Promotion of remyelination is an important therapeutic strategy for the treatment demyelinating neurological disorders. Adult oligodendrocyte precursor cells (OPCs), which normally reside quiescently in adult central nervous system (CNS), become activated and proliferative after lesions. However, extent endogenous limited because failure OPCs to mature into myelinating oligodendrocytes (OLs) demyelinated CNS. Understanding molecular mechanisms that regulate differentiation could...
Tumor-associated proteases (TAPs) have been intensively studied because of their critical roles in cancer development.As a case point, expression matrix metalloproteases (MMP) is significantly up-regulated tumorigenesis, invasion, and metastasis among majority cancers.Here we present prodrug-type, MMP-2-responsive nanoprobe system with high efficiency low toxicity for detecting MMP-2-overexpressed tumors.The featured by its self-assembled fabrication FRET effect.This prodrug-type selectively...
Abstract Hereditary nonpolyposis colorectal cancer (HNPCC) is often caused by a deficiency in DNA mismatch repair. By using conventional methods of mutation analysis, point mutations the repair genes MSH2 and MLH1 have been detected up to 64% patients suspected HNPCC. However, large genomic deletions cannot be these methods. In our study, we applied semiquantitative multiplex PCR detect proportion meeting Bethesda criteria whose tumours exhibited microsatellite instability (MSI). Of 368...
: Previous studies of coronavirus disease 2019 (COVID-19) were mainly focused on cross-sectional analysis. In this study, we sought to evaluate the dynamic changes immunological and radiographic features, association with outcome pulmonary lesions in COVID-19 patients.
Multiple double-wall shelled V<sub>2</sub>O<sub>5</sub> microspheres were synthesized by annealing solid vanadium-based precursors in air and exhibit improved electrochemical performance.
Abstract Image‐guided photodynamic therapy (PDT) has received growing attention due to its non‐invasiveness and precise controllability. However, the PDT efficiency of most photosensitizers are decreased in living system aggregation‐caused singlet oxygen ( 1 O 2 ) generation decreasing. Herein, we present an Iridium (III) pyridylpyrrole complex (Ir‐1) featuring aggregation‐induced emission (AIE) characteristics for image‐guided cancer. Ir‐1 aqueous solution exhibits bright red...
Strong evidence has linked overweight and obesity to increased risks of cardiovascular disease all-cause mortality in Chinese populations. Menopause is considered associated with central body fat distribution. However, the correlation between menopausal symptoms not been well studied.To examine associations or abdominal as women progressed from premenopausal postmenopausal status.This study included 430 midlife who had experienced natural menopause were followed up for 10 years. Physical...
Abstract Stroke has become the leading cause of mortality worldwide. Hypoxic or ischemic insults are crucial factors mediating neural damage in brain tissue stroke patients. Neural stem cells (NSCs) have been recognized as a promising tool for treatment and other neurodegenerative diseases due to their inducible pluripotency. In this study, we aim mimick cerebral hypoxic‐ischemic injury vitro using oxygen–glucose deprivation (OGD) strategy, evaluate effects OGD on NSC's differentiation, well...
Short-term spinal cord stimulation (st-SCS) has been widely used to treat herpetic-related neuralgia (HN) in China for several years, but is still heavily debated as it no strong evidence clinical application. Therefore, a questionnaire survey among the Chinese pain specialist workgroup of Neuromodulation Society and Medical Doctor Association was carried out achieve consensus about use st-SCS HN treatment.The contents include basic information doctors (hospital level, work experience,...
BMP7 has been shown to have neuroprotective effects and alleviate demyelination. However, its role in trigeminal neuralgia (TN) not well investigated. The current study aims determine whether plays a demyelination, on pain behaviors mechanism of action rats with TN.We used an infraorbital-nerve chronic-constriction injury (ION-CCI) establish rat model TN. Adeno-associated viruses (AAVs) were injected into the upregulate or downregulate BMP7. mechanical withdrawal thresholds (MWT) injured...
The intrinsic mechanism of postherpetic neuralgia (PHN) remains unclear. Herein, we aimed to seek the hub proteins in cerebrospinal fluid (CSF), which display significant changes between PHN and nonpainful patients (Control). First, proteomic results showed that compared with Control-CSF, there were 100 upregulated 50 downregulated differentially expressed (DEPs) PHN-CSF. Besides, functional analyses including gene ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), set enrichment...
A method for detection of large genomic deletions in the MSH2 and MLH1 genes based on multiplex PCR quantitative evaluation products is presented. All 35 exons were screened simultaneously seven reactions, each them including primers both genes. The reliable uncovering patients suspected HNPCC. With this method, six novel identified, two MSH2: EX1_10del EX1_16del (representing deletion entire gene); four MLH1: unrelated patients, EX3_5del, EX4del. detected 18 whom no germline mutation had...
During postherpetic neuralgia (PHN), the cerebral spinal fluid (CSF) possesses capability to trigger glial activation and inflammation, yet specific changes in its composition remain unclear. Recent findings from our research indicate elevations of central bone morphogenetic protein 4 (BMP4) during neuropathic pain (NP), serving as an independent modulator cells. Herein, aim present study is test CSF-BMP4 expressions role modulation process PHN.