A5101859685- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Metabolism and Genetic Disorders
- Multiple Sclerosis Research Studies
- Ion channel regulation and function
- Vagus Nerve Stimulation Research
- Diet and metabolism studies
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Herpesvirus Infections and Treatments
- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Brain Tumor Detection and Classification
- Fetal and Pediatric Neurological Disorders
- Cerebrospinal fluid and hydrocephalus
- Neuroinflammation and Neurodegeneration Mechanisms
- Polyomavirus and related diseases
- Pharmacological Receptor Mechanisms and Effects
- HIV Research and Treatment
- stochastic dynamics and bifurcation
- Salivary Gland Disorders and Functions
Beijing Sanbo Brain Hospital
2014-2025
Capital Medical University
2014-2025
Chinese Institute for Brain Research
2016-2023
Beijing Tian Tan Hospital
2006-2007
Beijing Institute of Neurosurgery
2001-2003
Abstract Autapses are synaptic contacts of a neuron’s axon onto its own dendrite and soma. In the neocortex, self-inhibiting autapses in GABAergic interneurons abundant number play critical roles regulating spike precision network activity. Here we examine whether principal glutamatergic pyramidal cells (PCs) also form functional autapses. patch-clamp recording from both rodent human PCs, isolated autaptic responses found that these occur predominantly layer-5 PCs projecting to subcortical...
Abstract We retrospectively analyzed the clinical characteristics of three ARE cases with delayed‐onset seizures treated at Peking University First Hospital and Sanbo Brain from May 2021 to January 2023. also reviewed previously reported atypical Rasmussen's encephalitis (RE) in literature, summarizing onset symptoms, seizure symptomatology, imaging findings, electroencephalogram (EEG) results, treatment course, prognosis. The age ranged 1 year 9 months 7 years 5 months. All initially...
Short-term spinal cord stimulation (st-SCS) has been widely used to treat herpetic-related neuralgia (HN) in China for several years, but is still heavily debated as it no strong evidence clinical application. Therefore, a questionnaire survey among the Chinese pain specialist workgroup of Neuromodulation Society and Medical Doctor Association was carried out achieve consensus about use st-SCS HN treatment.The contents include basic information doctors (hospital level, work experience,...
<b><i>Background:</i></b> Rasmussen encephalitis (RE) is a rare progressive that results in intractable seizures, cognitive decline and hemiparesis. Surgery seems to be the only effective way control seizures RE patients. <b><i>Objective:</i></b> To describe clinical, electrophysiological, neuroradiological histological findings of our patients with evaluate outcome their surgical treatment. <b><i>Methods:</i></b> A...
Rasmussen encephalitis (RE) is a rare neurologic disorder of childhood characterized by unihemispheric inflammation, progressive deficits, and intractable focal epilepsy. The pathogenesis RE still enigmatic. Adenosine key endogenous signaling molecule with anticonvulsive anti-inflammatory effects, our previous work demonstrated that dysfunction the adenosine kinase (ADK)-adenosine system astrogliosis are hallmarks We hypothesized epileptogenic mechanisms underlying related to changes in ADK...
Rasmussen encephalitis (RE) is a rare neurological disorder characterized by unilateral inflammation of cerebral cortex and other structures, most notably the hippocampus, progressive cognitive deterioration, pharmacoresistant focal epilepsy. The pathogenesis RE with cortical atrophy seizures still enigmatic. Activation adenosine A1 receptors (A1R) has been proven to prevent spatial spread seizures. We hypothesized that epileptogenic mechanisms underlying are related changes in neuronal A1R...
Rasmussen's encephalitis (RE) is a rare and severe progressive epileptic syndrome with unknown etiology. Infection by viruses such as human cytomegalovirus (HCMV) has been hypothesized to be potential trigger for RE. Interferon-induced transmembrane protein-3 (IFITM3) single-nucleotide polymorphism (SNP) rs12252 associated the severity of viral infection disease. This study aimed address possibility that HCMV IFITM3 might RE disease progression.
Objective To evaluate the influencing factors and cognitive functional changes in Rasmussen encephalitis (RE) patients who received a hemispherectomy.Methods Forty RE underwent hemispherectomy with at least 2 years follow- up were included this study . Postoperative seizure outcomes evaluated according to Engle classification scale. Univariate analysis multivariate logistic regression model backward fashion used identify potential predictors of function.Results All 40 had an outcome...
Background Traumatic brain injury (TBI) has been recognized as an important and common cause of epilepsy since antiquity. Posttraumatic (PTE) is usually associated with drug resistance poor surgical outcomes, thereby increasing the burden illness on patients their families. Vagus nerve stimulation (VNS) adjunctive treatment for medically refractory epilepsy. This study aimed to determine efficacy VNS PTE initially evaluate potential predictors efficacy. Methods We retrospectively collected...
Infantile spasm (IS) syndrome is an age-related epileptic encephalopathy that occurs in children. The purpose of this study was to investigate regional homogeneity (ReHo) changes IS patients. Resting-state fMRI performed on 11 patients with IS, along 35 age- and sex-matched healthy subj ects. Group comparisons between the two groups demonstrate pattern synchronization changed. Decreased ReHo values were found default mode network, bilateral motor-related areas left occipital gyrus patient...
It has previously been demonstrated that there are various voltage gated sodium channel (Nav) 1.5 splice variants expressed in brain tissue. A total of nine Nav1.5 isoforms have identified, however, the potential presence further neurons remains to be elucidated. The present study systematically investigated expression and their associated electrophysiological properties rat tissue, via biochemical analyses whole‑cell patch clamp recording. results adult was rat, addition neonatal Nav1.5,...
Ifenprodil has been demonstrated to reduce spontaneous action potentials observed by local field potential in animal models. To investigate whether ifenprodil exerts an anti-epileptic effect on neuronal levels humans, whole-cell patch clamp recordings were used study the electrophysiological membrane properties of neocortical pyramidal neurons human brain tissues. Electrophysiological and spikes investigated using recordings, prior following application ifenprodil. In present study,...
Previous studies demonstrated that Nav1.5 splice variants, including Nav1.5a and Nav1.5c, were expressed in dorsal root ganglia (DRG) neurons. However, since nine isoforms have been identified, whether other especially the neonatal variant, express DRG neurons is still unknown. In this study, we systematically investigated expression of adult axon peripheral sensory rats with spared nerve injury (SNI) by RT-PCR, DNA sequencing, restriction enzyme digestion, immunohistochemistry...
OBJECTIVE The authors of this study aimed to investigate surgical outcomes and prognostic factors in older patients with drug-resistant temporal lobe epilepsy (TLE) who had undergone resective surgery. METHODS Data on than 45 years age TLE surgery at Sanbo Brain Hospital, Capital Medical University, between January 2009 August 2017 were retrospectively collected. Postoperative seizure evaluated according the International League Against Epilepsy (ILAE) classification. Patients belonging ILAE...
Abstract Researchers have widely acknowledged the therapeutic value of epilepsy surgery for drug-resistant epilepsy. Nonetheless, there is a substantial gap in surgical treatment appropriate candidates owing to several factors, particularly population young children. To standardize protocols preoperative evaluation and children surgery, China Association Against Epilepsy has appointed an expert task force pediatric patients. It adopted modified Delphi method performed two rounds surveys...
Rasmussen's encephalitis (RE) is a rare chronic neurological disorder characterized by unihemispheric brain atrophy and epileptic seizures. The mechanisms of RE are complex. Adaptive immunity, innate immunity viral infection all involved in the development RE. However, there few studies on role genetic factors Thus, objective this study was to reveal Whole-exome sequencing (WES) performed 15 patients. Ten patients with temporal lobe epilepsy (TLE), which common frequently intractable seizure...
Resecting epileptogenic foci combined with bipolar electrocoagulation of functional cortex has been successfully used to treat intractable epilepsy.124 cases epilepsy have treated from 1996 1999, 75 temporal lobe and 48 extra-temporal epilepsy, one case infantile hemiplegia. Electrocorticography (ECoG) was pre- postoperatively. 108 were followed-up three years.The general efficiency on (BCFC) for is 91.7%. The pathological features indicate that the damage by coagulation only in supra-...