A5113125482- Lipid Membrane Structure and Behavior
- Antimicrobial Peptides and Activities
- Estrogen and related hormone effects
- Biochemical and Structural Characterization
- Neuroscience and Neuropharmacology Research
- ATP Synthase and ATPases Research
- Energy Efficiency and Management
- GDF15 and Related Biomarkers
- Neuroendocrine Tumor Research Advances
- Eosinophilic Esophagitis
- Epilepsy research and treatment
- Protein Structure and Dynamics
- Heat shock proteins research
- Glioma Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Reproductive Biology and Fertility
- Ubiquitin and proteasome pathways
- Building Energy and Comfort Optimization
- Supramolecular Self-Assembly in Materials
- Ovarian cancer diagnosis and treatment
- Pancreatic function and diabetes
- Electrospun Nanofibers in Biomedical Applications
- Cellular transport and secretion
- Vascular Malformations and Hemangiomas
- Mast cells and histamine
Xijing Hospital
2024
Air Force Medical University
2024
Kunming Medical University
2024
Medical University of Vienna
2013
The Affiliated Yongchuan Hospital of Chongqing Medical University
2006-2013
Chongqing Medical University
2006-2013
The Ohio State University
2006-2010
Cyanuric acid (CA) and melamine (M) functionalized lipids can form membranes that exhibit robust hydrogen-bond driven surface recognition in water, facilitated by multivalent clustering of groups variable hydration at the lipid−water interface. Here we describe a minimal lipid cluster: three CA or M are forced into proximity covalent attachment to single headgroup. This trivalent system guides interface using cyanurate−melamine hydrogen bonding when incorporated 0.1−5 mol percent fluid...
Abstract Mitochondrial‐nuclear communication plays a vital role in maintaining cellular homeostasis. MOTS‐c, short peptide derived from the 12S rRNA of mitochondrial DNA, has been suggested as retrograde signal. Although recent clinical studies have possible link between MOTS‐c and human cancer, tumorigenesis yet to be investigated. Here, levels are found reduced both serum tumor tissues ovarian cancer (OC) patients, which associated with poor patients’ prognosis. Exogenous inhibits...
Ovarian cancer (OC), as a malignant tumor that seriously endangers the lives and health of women, is renowned for its complex heterogeneity. Multi-omics analysis, an effective method distinguishing heterogeneity, can more accurately differentiate prognostic subtypes with differences among patients OC. The aim this study to explore OC analyze molecular characteristics different subtypes. We utilized 10 clustering algorithms multi-omics data from Cancer Genome Atlas (TCGA). After that, we...
We report herein the induction of selective vesicle fusion with biological recognition motifs not natively associated lipid bilayer fusion, thus broadening scope recognition-guided membrane activation. Our system employs vancomycin glycopeptide, coupled to antimicrobial peptide magainin, and D-Ala-D-Ala-OH dipeptide a phospholipid derivative, as surface-bound fusogens. Fusion was characterized by dynamic light scattering FRET experiments bound fluorophores. have demonstrated here that...
Selective membrane mergers may be driven by small-molecule recognition between synthetic surface-displayed fusogens which bear vancomycin glycopeptide and its native binding target, D-Ala-D-Ala dipeptide. These motifs are anchored antimicrobial peptide magainin II a phosphatidylethanolamine lipid derivative, respectively. We report herein characterization of this fusion reaction with regard to the following: effects fusogen concentration, composition, charge. Our findings indicate that these...
Extracellular signal‐regulated kinases (ERK) such as ERK1 [p44 mitogen‐activated protein kinase (MAPK)] and ERK2 (p42 MAPK) are activated in the central nervous system under physiological pathological conditions ischemia epilepsy. Our aim is to investigate ERK1, ERK2, phosphorylated ERK (p‐ERK) (Thr202/Tyr 204) expression temporal lobe of patients with intractable epilepsy (IE) explore its possible role it. Tissue samples from neocortices 40 who had surgery for IE were used detect p‐ERK (Thr...
Abstract Heat Shock Protein BAP1 (heat shock 27‐kDa‐associated protein 1, HSPBAP1) inhibits the function of heat 27, which has a neuroprotective effect during experimentally induced epileptic neuropathology. In our study, fluorescence quantitative polymerase chain reaction, immunohistochemistry, immunofluorescence, western blot were used to test levels HSPBAP1 mRNA and in surgical samples anterior temporal neocortex patients with intractable epilepsy (IE) normal controls samples. was...
The corpus luteum (CL) is under control of gonadotrophic hormones and produces progesterone, which necessary for endometrial receptivity. Recent studies have shown that progesterone its metabolites are involved in cell proliferation apoptosis cancer cells. Here weanalyzed the role metabolites on luteinized granulosa cells (LGC) by FACS analysis quantitative Real-Time PCR. We detected mRNA metabolizing genes SRD5A1, AKR1C1, AKR1C2 LGC. stimulation LGC with or did not show any effect...
The sustainable development and intelligent construction of building energy systems have become an inevitable trend global development. indoor temperature control has gradually played important role in promoting saving consumption reduction buildings the whole society. According to physical characteristics wall, this paper constructs a RC network thermodynamic model system. Taking room comfort economy as optimization goals, deep reinforcement learning algorithm, namely, deterministic policy...