A5067844998- Phytoplasmas and Hemiptera pathogens
- Cocoa and Sweet Potato Agronomy
- Plant Pathogenic Bacteria Studies
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Alzheimer's disease research and treatments
- Research Data Management Practices
- Growth Hormone and Insulin-like Growth Factors
- Effects and risks of endocrine disrupting chemicals
- Optical Imaging and Spectroscopy Techniques
- Hypothalamic control of reproductive hormones
- Estrogen and related hormone effects
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Studies on Chitinases and Chitosanases
- Plant Virus Research Studies
- Genetics, Bioinformatics, and Biomedical Research
- Language, Metaphor, and Cognition
- Copyright and Intellectual Property
- Plant Pathogens and Fungal Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Thermoregulation and physiological responses
- scientometrics and bibliometrics research
- Neuroscience and Neuropharmacology Research
- Hormonal Regulation and Hypertension
MoreBrains Cooperative (United Kingdom)
2021-2024
University of Edinburgh
2019-2024
Iowa State University
2020
Valparaiso University
2020
University of Groningen
2020
University of Delaware
2019
Institute of Genetics and Cancer
2019
New York University Press
2017
Zhejiang University
2017
Hallym University
2017
Ischemic depolarizing events, such as repetitive spontaneous periinfarct spreading depolarizations (PIDs), expand the infarct size after experimental middle cerebral artery (MCA) occlusion. This worsening may result from increased metabolic demand, exacerbating mismatch between blood flow (CBF) and metabolism. Here, we present data showing that anoxic depolarization (AD) PIDs caused vasoconstriction abruptly reduced CBF in ischemic cortex a distal MCA occlusion model mice. reduction during...
The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) may produce its effects by altering gene expression in susceptible cells. In mouse hepatoma cells, TCDD induces the transcription of cytochrome P1-450 gene, whose product, aryl hydrocarbon hydroxylase, contributes both to detoxification and metabolic activation carcinogenic polycyclic aromatic hydrocarbons. A DNA fragment containing sequences flanking 5' end was isolated analyzed. This contains a cis-acting control...
Inhibin is a gonadal protein hormone that suppresses the secretion of FSH from pituitary gonadotrophs. It has previously been characterized as heterodimer two dissimilar subunits (α, 18 kilodaltons and β, 14 kilodaltons) smaller which exists in forms (βA βB) can form dimers stimulate FSH. In present work, cDNA clones encoding inhibin α- βAsubunits have isolated rat ovary characterized. The α-inhibin predicts precursor 366 amino acids containing 133 acid mature α-subunit at its COOH-terminus....
Epidermal growth factor (EGF), but not fibroblast factor, inhibits the gonadotropin stimulation of estrogen and testosterone production by primary cultures ovarian granulosa testicular Leydig cells, respectively. EGF also gonadal steroidogenesis induced cholera toxin (Bu)2cAMP, inhibitory effect is associated with cell proliferation. may play an important endocrine role in regulation steroidogenic functions cells.
The Tg2576 transgenic mouse model of human cerebral amyloid angiopathy is characterized by age-dependent cerebrovascular deposition amyloid-beta (Abeta) starting from 9 months age and progressively worsening to involve most pial arterioles 18 months; soluble Abeta levels are elevated long before vascular takes place in this model. It has been suggested that alone sufficient impair blood flow (CBF) regulation thereby contributing the early progression Alzheimer's disease. Using laser speckle...
Normobaric hyperoxia is under investigation as a treatment for acute ischaemic stroke. In experimental models, normobaric reduces cerebral injury and improves functional outcome. The mechanisms of neuroprotection are still debated because, (i) inhalation 100% O2 does not significantly increase total blood content; (ii) it known whether increases delivery to the severely cortex because its short diffusion distance; (iii) may reduce collateral flow (CBF) penumbra can cause vasoconstriction. We...
In focal ischemic cortex, cerebral blood flow autoregulation is impaired, and perfusion passively follows pressure variations. Although it generally agreed that profound hypotension harmful in acute stroke, the hemodynamic metabolic impact of increased on core penumbra are less well understood. We, therefore, tested whether pharmacologically induced hypertension improves metabolism tissue outcome stroke using optical imaging with high spatiotemporal resolution.Cerebral flow, oxyhemoglobin,...
We analyzed the function and sequence of a dioxin-responsive genomic element flanking 5' end cytochrome P1-450 gene in high-activity variant mouse hepatoma cells. The can regulate mammary tumor virus promoter. retains responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) when distance, or 3' position, and/or orientation with respect promoter are varied. requires TCDD-receptor complexes. remains responsive TCDD transfected into cells from either heterologous tissue species (human). DNA...
androstenedione, A4-androstene-3,17-dione; cyanoketone, 2a-cyano
Accumulation of neurofibrillary tangles (NFTs) in Alzheimer's disease correlates with neuronal loss and cognitive decline, but the precise relationship between NFTs death downstream mechanisms cell remain unclear. Caspase cleaved products accumulate tangles, implying that may contribute to apoptotic death. To test this hypothesis, we developed methods using multiphoton imaging detect both pathology caspase activation living mouse brain. We examined rTg4510 mice, a reversible model tauopathy...
Tau protein is present in six different splice forms the human brain and interacts with microtubules via either 3 or 4 microtubule binding repeats. An increased ratio of repeat to isoforms associated neurodegeneration inherited frontotemporal dementia. over-expression diminishes axonal transport several systems, but differential effects have not been studied. We examined tau on mitochondrial found that both change normal distribution within cell body reduce localization axons; has a greater...
Real-time investigation of cerebral blood flow (CBF), and oxy- deoxyhemoglobin concentration (HbO, HbR) dynamics has been difficult until recently due to limited spatial temporal resolution techniques like laser Doppler flowmetry magnetic resonance imaging (MRI). The combination speckle (LSF) multispectral reflectance (MSRI) yields high-resolution spatiotemporal maps hemodynamic metabolic changes in response functional cortical activation. During acute focal ischemia, HbO HbR are much larger...
Functional hemodynamic responses are the composite results of underlying variations in cerebral oxygen consumption and dilation arterial vessels after neuronal activity. The development biophysically based models vasculature allows separation neuro-metabolic neuro-vascular influences on measurable signals such as functional magnetic resonance imaging or optical imaging. We describe a multicompartment model vascular transport dynamics associated with stimulus-driven activation. Our offers...
Leukotrienes (LTs) are signaling molecules derived from arachidonic acid that initiate and amplify innate adaptive immunity. In turn, how their synthesis is organized on the nuclear envelope of myeloid cells in response to extracellular signals not understood. We define supramolecular architecture LT by identifying activation-dependent assembly novel multiprotein complexes outer inner membranes mast cells. These centered integral membrane protein 5-Lipoxygenase-Activating Protein, which we...
During 2003, surveys of sugarcane yellow leaf disease and papaya bunchy top-like were carried out on plantations in Havana province, Cuba, to determine the roles weeds Auchenorrhyncha insects epidemiology these diseases. More than 250 plant insect samples collected indexed by using a nested PCR for phytoplasma 16S rDNA with generic primer pairs P1/P7 R16F2n/R16R2. The products further characterized restriction fragment length polymorphism Hae III, Alu I, Sau 3AI, Tru 9I, Hha Hpa II Taq I...
Ubiquilin 1 (UBQLN1) is a ubiquitin-like protein, which has been shown to play central role in regulating the proteasomal degradation of various proteins, including presenilins. We recently reported that DNA variants UBQLN1 increase risk for Alzheimer disease, by influencing expression this gene brain. Here we present first assessment effects on metabolism amyloid precursor protein (APP). For purpose, employed RNA interference down-regulate variety neuronal and non-neuronal cell lines....
In mouse hepatoma cells, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) stimulates cytochrome P1-450 gene transcription via the formation of TCDD-receptor complexes and accumulation in nucleus.Here, we show that DNA flanks 5'-end contains at least two discrete TCDD-responsive domains.Each domain has properties analogous to those transcriptional enhancers.Each requires for its function.There is no significant nucleotide sequence homology between TCDDresponsive domains.Halogenated aromatic...