A5050544454- Gut microbiota and health
- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Electrospun Nanofibers in Biomedical Applications
- Sirtuins and Resveratrol in Medicine
- Parkinson's Disease Mechanisms and Treatments
- Clostridium difficile and Clostridium perfringens research
- Advanced Sensor and Energy Harvesting Materials
- Nuclear Receptors and Signaling
- Nanoparticle-Based Drug Delivery
- SARS-CoV-2 and COVID-19 Research
- Neurological diseases and metabolism
- Prion Diseases and Protein Misfolding
- CRISPR and Genetic Engineering
- Advanced Photocatalysis Techniques
- GABA and Rice Research
- Insect Resistance and Genetics
- RNA Interference and Gene Delivery
- Genetics, Aging, and Longevity in Model Organisms
- Microbial Natural Products and Biosynthesis
- Probiotics and Fermented Foods
- Mosquito-borne diseases and control
- Tactile and Sensory Interactions
- Cerebrovascular and genetic disorders
Jeonbuk National University
2016-2025
Pohang University of Science and Technology
2015-2021
Yale University
2019
Bio-Medical Science (South Korea)
2017
Seonam University
2016
JINIS Biopharmaceuticals (South Korea)
2002-2013
Pusan National University
2013
Korea University
2010
Chonbuk National University Hospital
2005-2010
Samsung (South Korea)
2007
The prevailing amyloid hypothesis for Alzheimer's disease (AD) holds that beta-protein (Abeta) causes neuronal degeneration by forming neurotoxic fibrillar structures. Yet, many aspects of AD pathology and symptoms are not well explained this hypothesis. Here, we present evidence neurotoxicity soluble oligomeric Abeta closely corresponds to the selective neurodegeneration so distinctly manifest in AD. Selectivity was first observed vitro, where only human central nervous system cells were...
The current gut microbiome research relies on the fecal under assumption that represents of entire gastrointestinal (GI) tract. However, there have been growing concerns about using feces as a proxy to study microbiome. Here, we comprehensively analyzed composition and metabolites in at 14 different locations GI tracts genetically homogenous sibling pigs evaluate validity whole intestinal microbes constituting each content their metabolic compositions were thoroughly investigated through...
Abnormal behavior of α-synuclein and prion proteins is the hallmark Parkinson’s disease (PD) illnesses, respectively, being complex neurological disorders. A primary cause protein aggregation, brain injury, cognitive loss in illnesses misfolding normal cellular (PrP C ) into an infectious form Sc ). Aggregation causes disruptions processes (PD), leading to dopamine-producing neurons motor symptoms. Alteration composition or activity gut microbes may weaken intestinal barrier make it possible...
Resveratrol has been clinically shown to possess a number of human health benefits. As result, many attempts have made engineer resveratrol production in major cereal grains but largely unsuccessful. In this study, we report the creation transgenic rice plant that accumulates 1.9 µg resveratrol/g its grain, surpassing previously reported anti-metabolic syndrome activity through synergistic interaction between and endogenous properties rice. Consumption our resveratrol-enriched significantly...
Recently, many nanomedical studies have been focused on magnetic nanoparticles (MNPs) because MNPs possess attractive properties for potential uses in imaging, drug delivery, and theranostics. must optimized size as well functionalized surface such applications. However, careful cytotoxicity genotoxicity assessments to ensure the biocompatibility biosafety of are essential. In this study, Fe3O4 different sizes (approximately 10 100–150 nm) were prepared with functional groups, hydroxyl (–OH)...
Recent findings on the association of gut microbiota with various diseases, including obesity, prompted us to investigate possibility using a certain type bacteria as safe therapeutic for obesity. Lactobacillus mutants enhanced capacity in absorption free fatty acids (FFAs) were isolated show reduced FFAs by administered host, attributing inhibition body weight gain and fat accumulation well amelioration blood profiles. Consequently, high throughput screening natural FFAs-absorbing...
The gut microbiome is well known for its influence on human physiology and aging. Therefore, we speculate that the may affect muscle strength in same way as host’s own genes. To demonstrate candidates microbes affecting strength, remodeled original of mice into intestinal through fecal transplantation (FMT), using feces compared changes before three months after FMT. After comparing FMT, were divided groups based observed strength: positive, none, negative strength. As a result analyzing...
Despite the potential protective role of gut microbiome against COVID-19, specific microbes conferring resistance to COVID-19 have not yet been identified. In this work, we aimed identify and validate at species level that provide protection SARS-CoV-2 infection. To conducted a fecal microbiota transplantation (FMT) from an individual with no history infection or immunization into lethal hamster model. FMT COVID-19-resistant donor resulted in significant phenotypic changes related...
The association between the triglyceride-glucose (TyG) level, its obesity-related derivatives, and occurrence of endometriosis (EMS) remains ambiguous, particularly in individuals with higher levels education. This study sought to explore relationship TyG, EMS across various educational backgrounds. utilized a substantial dataset obtained from four cycles National Health Nutrition Examination Survey (NHANES) conducted 1999 2006. To EMS, we employed variety analytical methods, including...