A5023628626- Infrastructure Maintenance and Monitoring
- Asphalt Pavement Performance Evaluation
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Nanoparticle-Based Drug Delivery
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- RNA Interference and Gene Delivery
- Crystallography and molecular interactions
- Geotechnical Engineering and Underground Structures
- Grouting, Rheology, and Soil Mechanics
- Thermography and Photoacoustic Techniques
- Extracellular vesicles in disease
- Curcumin's Biomedical Applications
- Concrete and Cement Materials Research
- Photodynamic Therapy Research Studies
- Material Properties and Processing
- Adenosine and Purinergic Signaling
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Fibroblast Growth Factor Research
- Automated Road and Building Extraction
- Concrete Corrosion and Durability
- Advanced materials and composites
- Grey System Theory Applications
- Advanced biosensing and bioanalysis techniques
Xinjiang University
2022-2025
Inner Mongolia Electric Power Survey & Design Institute (China)
2025
China Communications Construction Company (China)
2022-2024
Shenzhen Institutes of Advanced Technology
2014-2023
Chinese Academy of Sciences
2013-2023
National Research Center for Rehabilitation Technical Aids
2021-2022
Tongji University
2022
State Power Investment Corporation (China)
2021
Shanxi Provincial Traffic Planning Survey and Design Institute
2021
Chang'an University
2019
“All-in-one” carrier-free-based nano-multi-drug self-delivery system could combine triple advantages of small molecules, nanoscale characteristics, and synergistic combination therapy together. Researches have showed that dual-acting small-molecular methotrexate (MTX) target kill the folate-receptor-overexpressing cancer cells. Inspired by this mechanism, a novel collaborative early-phase tumor-selective targeting late-phase anticancer approach was developed for self-assembly...
Pavement images have been utilised to detect distresses. However, existing methods for detecting pavement distresses are not acceptable owing the various real-world conditions. To complete task, a novel detection method based on faster region convolutional neural network (Faster R-CNN) was recognise and locate including crack, pothole, oil bleeding dot surface autonomously. Twenty Faster R-CNNs were trained tested by 6498 images. Then performance of training analysed select optimal R-CNN. At...
The in vivo applications of gas-core microbubbles have been limited by gas diffusion, rapid body clearance, and poor vascular permeability.To overcome these limitations, using a modified three-step emulsion process, we developed first-of-its-kind India ink incorporated optically-triggerable phase-transition perfluorocarbon nanodroplets (INDs) that can provide not only three types contrast mechanisms-conventional/thermoelastic photoacoustic, phase-transition/ nonlinear ultrasound imaging...
Nanoparticles (NPs) functionalized with targeting ligands have shown promise, but are still limited by their nonspecific uptake certain healthy tissues and cells that express low or even comparable levels of receptors. To increase accumulation at tumor sites while decreasing the unintended toxicity, a possible solution is involvement two separate tumor-specific in localization. In this study, dual tumor-targeting drug-loaded NP system was self-assembled amphiphilic conjugate...
In engineering practice, recycled asphalt pavement (RAP) is often obtained from various sources and mixed stockpiled in a disorderly manner, which defined as hybrid RAP. Thus, the material component of RAP shows great variability, possibly preventing plant hot-mix mixture (RHMA) achieving stable quality. To address this problem, German TL Asphalt-StB 07 guideline introduced an approach for evaluating variability stockpile characteristics subsequently determined maximum permissible content...
This study systematically investigates the rheological modification mechanism of steel slag powder (SSP) as an alternative filler in asphalt mastics, with comparative analysis against conventional limestone (LP). Four filler-to-asphalt (F/A) ratios (0.6–1.2) were employed to prepare modified mastics. Comprehensive characterization through laser diffraction analysis, BET nitrogen adsorption, and scanning electron microscopy (SEM) revealed SSP’s significant microstructural advantages: a 29.2%...
The characteristics of pavement texture are key determinants skid resistance, directly affecting tire-pavement interactions. This study examines the relationship between separated textures and friction coefficients under dry wet conditions. Using 3D laser scanning, data were collected from 40 asphalt sections in Nanchang. processed through Fourier Transform Butterworth filtering, enabling separation macro- micro-textures. Based on ISO 25178-2, 16 parameters—including Sa (Arithmetic Mean...
Recently, the global trend in field of nanomedicine has been toward design combination nature active constituents and phospholipid (PC) to form a therapeutic drug-phospholipid complex. As particular amphiphilic molecular complex, it can be unique bridge traditional dosage-form novel drug delivery system. In thisarticle, on basis complex technique self-assembly technique, we chose pharmacologically safe low toxic curcumin (CUR) increase drug-loading ability, achieve controlled/sustained...
Tumor-targeting combination chemotherapy is an important way to improve the therapeutic index and reduce side effects as compared traditional cancer treatments. However, one of major challenges in surface functionalization nanoparticle (NP) accomplishing multiple purposes through single ligand. Upon such consideration, methotrexate (MTX), anticancer drug with a targeting moiety inspired by similar structure folate, could be used covalently link lipid-polymer conjugate (DSPE-PEG) via...
The shortage of natural aggregates is becoming a severe problem in the pavement industry globally. To address this issue, study, an effort was made to use reclaimed asphalt (RAP) and coal gangue (CG) as coarse fine aggregate, respectively for producing hot mix (HMA). As replacement there were seven types HMA containing 20% 40% RAP aggregate content, 10% 25% CG content designed prepared. In addition, Marshall Stability test, rutting resistance immersion freezing-thaw splitting...
The biomedical imaging of metastatic breast cancer, especially in lymphatic and lung metastasis, is highly significant cancer staging as it helps assess disease prognosis treatment. Using an albumin-indocyanine green dual-modal nanoprobe developed our laboratory, vivo fluorescence photoacoustic tumors were performed separately. Fluorescence at the near-infrared window features high sensitivity but generally limited by a low depth. Thus, can only be observed situ whereas tumor cells lymph...
In order to investigate the potential application of low-grade hard asphalt in high-temperature and high-altitude areas, various tests were conducted analyze performance rheological properties 30#, 50#, 70# matrix under thermo-oxidative aging ultraviolet aging. The utilized for analysis included examination basic properties, Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), gel permeation chromatography (GPC), dynamic shear rheology (DSR), multi-stress creep...
When using a high concentration of reclaimed asphalt pavement (RAP) in recycled hot-mix mixture (RHMA), the degree blending binder significantly affects performance RHMA. Hence, it is essential to know RAP and its effect on environmental impact RHMA order determine optimal mixing duration. To this end, dispersion was observed artificial image analysis method, with different durations also evaluated physical properties tests, rheometer test, Fourier-transform infrared spectroscopy (FTIR) gel...
Self-assembly of multifunctional integrated nanoparticles loaded with methotrexate-phospholipid complex have both targeting and anticancer effect to FA receptors overexpressed cancer cells.
This study investigates the fluence rate effect, an essential modulating mechanism of photodynamic therapy (PDT), by using photoacoustic imaging method. To best our knowledge, this is first time that dependence investigated at a microscopic scale, as opposed to previous studies are based on tumor growth/necrosis or animal surviving rate. micro-scale examination enables subtle biological responses, including vascular damage and self-healing response, be studied. Our results reveal...
Photoacoustic computed tomography (PACT) is a fast-developing biomedical imaging modality and has immense potential for clinical translation. It utilizes laser excitation acoustic detection to achieve high spatial resolution considerable depth in biological tissues. Current PACT primarily treats the absorption coefficient of tissues as scalar variable while reconstructing image, which limits its use anisotropic evaluation Thus, by incorporating polarized methods evaluate anisotropy,...
Hypoxia is a critical tumor microenvironment (TME) component. It significantly impacts growth and metastasis known to be major obstacle for cancer therapy. Integrating hypoxia modulation with imaging-based monitoring represents promising strategy that holds the potential enhancing theranostics. Herein, kind of nanoenzyme Prussian blue (PB) synthesized as metal-organic framework (MOF) load second near-infrared (NIR-II) small molecule dye IR1061, which could catalyze hydrogen peroxide produce...