A5100732169- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Video Coding and Compression Technologies
- Cancer Immunotherapy and Biomarkers
- Pharmacogenetics and Drug Metabolism
- Virus-based gene therapy research
- Immune cells in cancer
- Antimicrobial Peptides and Activities
- Surfactants and Colloidal Systems
- Marine Sponges and Natural Products
- Advanced Data Compression Techniques
- Biochemical and Structural Characterization
- vaccines and immunoinformatics approaches
- Crystallization and Solubility Studies
- Lipid Membrane Structure and Behavior
- Analytical Chemistry and Chromatography
- Heavy Metals in Plants
- Education and Work Dynamics
- Extracellular vesicles in disease
- Embedded Systems and FPGA Design
- Advanced Drug Delivery Systems
Xiamen University
2011-2024
Ministry of Agriculture and Rural Affairs
2024
Feed Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
Shijiazhuang University
2022
Beijing University of Civil Engineering and Architecture
2019
China Jiliang University
2008-2018
China University of Petroleum, East China
2017
Children's Hospital of Zhejiang University
2012
Shenyang Pharmaceutical University
2005
Aim: To explore the therapeutic effect of nanoparticle-based dual-targeting delivery antitumor agents for glioblastoma treatment. Materials & methods: A hepatitis B core protein-virus-like particle (VLP)-based system was designed with primary brain targeting peptide TGN blood–brain barrier penetration and tumor vascular preferred ligand RGD (arginine–glycine–aspartic acid) targeting. Chemo- gene-therapeutic paclitaxel siRNA were co-packaged inside vehicle. Results: The results demonstrated...
To accomplish effective cancer imaging and integrated therapy, the multifunctional nanotheranostic Fe3O4-MTX@HBc core-shell nanoparticles (NPs) were designed.A straightforward method was demonstrated for efficient encapsulation of magnetic NPs into engineered virus-like particles (VLPs) through affinity histidine tags methotrexate (MTX)-Ni 2+ chelate.HBc144-His VLPs shell could protect Fe3O4-MTX from recognition by reticuloendothelial system as well increase their cellular uptake...
Antibacterial coating with antibiotics is highly effective in avoiding device-associated infections (DAIs) which an unsolved healthcare problem that causes significant morbidity and mortality rates. However, bacterial drug resistance caused by uncontrolled release of seriously restricts clinical efficacy antibacterial coating. Hence, a local controlled-release system can response to infected signals necessary Herein, multi-stimulus responsive multilayer was prepared through layer-by-layer...
The orphan nuclear receptor Nur77 is emerging as an attractive target for cancer therapy, and activating Nur77's non-genotypic anticancer function has demonstrated strong therapeutic potential. However, few site B ligands have been identified excellent compounds. There are no co-crystal structures of effective agents at B, which greatly limits the development novel ligands. Moreover, lack pharmaceutical restricts proof concept. Herein, we developed a first-in-class ligand (NB1) that...
Detailed chemical investigation of the South China sponge Dysidea arenaria resulted in isolation a new sesquiterpenoid hydroquinone, 19-hydroxypolyfibrospongol B (1), along with five known compounds: polyfibrospongol (2), isosemnonorthoquinone (3), ilimaquinone (4), smenospongine (5) and smenotronic acid (6). The structures were determined by extensive spectroscopic analysis. vitro anti- HIV activity on HIV-1 RT was evaluated. Compounds 3 -6 displayed moderate inhibitory activity, IC50...
Penicillum citreonigrum XT20-134 (MCCC 3A00956) is a fungus with cytotoxic activity, derived from deep-sea sediment. Five new compounds, adeninylpyrenocine (1), 2-hydroxyl-3-pyrenocine-thio propanoic acid (2), ozazino-cyclo-(2,3-dihydroxyl-trp-tyr) (3), 5,5-dichloro-1-(3,5-dimethoxyphenyl)-1,4-dihydroxypentan-2-one (4), and 2,3,4-trihydroxybutyl cinnamate (5), together 19 known compounds (6-24), were isolated an ethyl acetate (EtOAc) extract of its fermentation. The structures the...
Near-infrared (NIR) triggered cyanine dyes have attracted considerable attention in multimodal tumor theranostics. However, NIR used treatment often suffer from low fluorescence intensity and weak singlet oxygen generation efficiency, resulting inadequate diagnostic therapy efficacy for tumors. It is still a great challenge to improve both the photodynamic (PDT) fluorescent imaging (FLI) of applications. Herein, novel multifunctional nanoagent AuNRs@SiO2-IR795 was developed realize...
The infrared absorption spectrum due to structural vibrations in molecules has been widely used resolve chemical identification.However, this method is limited by the weak molecule-light interaction.Graphene plasmon, having strong confinement and large field enhancement, provides a promising way increase their interactions.Here we propose tunable hybridization-induced graphene nanostructures for sensing application.Our results reveal that when symmetry of disk broken introducing small...
Advanced antibacterial methods are urgently needed to deal with possible infectious diseases. As promising alternatives antibiotics, enzyme-mimic nanocatalysts face bottlenecks of low activities and indistinct catalytic mechanisms, which seriously restrict their development for anti-infection treatment. Herein, metastable copper sulfide (Cu2-xS) nanozymes diversiform sizes compositions were selected adjust the electronic structure enhancing activities. The as-synthesized large thin...
Nitric oxide is critical for eliminating infection and promoting regeneration in diabetic wounds. However, clinical uses of nitric are limited by its high activity lack specificity targeting infections. Herein, we develop an intelligent nanogenerator comprising isosorbide dinitrate (ISDN)-coated copper sulfide (CuS)/calcium carbonate (CaCO3) core/shell nanoparticles (CuS@CaCO3-ISDN) to target the acidic microenvironment infected Meaningfully, triggered acid decomposition CaCO3, this can...
Molecular dynamics simulations were carried out to investigate the aggregation behavior of anionic surfactant sodium dodecyl sulfate (SDS) on surfaces SiO 2 and CaCO 3 . The results indicate that SDS molecules formed a spherical micelle structure near surface; moreover, there more head groups surface. However, they could form self‐assemble film surface was stable than Our simulation have certain significance understand different molecular level.
How to further increase the upconversion luminescence (UCL) efficiency of core-shell nanoparticles (UCNPs) is highly desirable for their photoelectric and bio-logical applications. Herein, a novel but facile strategy proposed substantially enhance UCL intensity NaYF4 based UCNPs by morphological control. The morphologies can be optimized from rod-like spherical like changing ratio oleic acid (OA) 1-octadecene (ODE) during shell growth process with other reaction conditions constant....
The tumor microenvironment typically possesses immunosuppressive properties that hinder the effectiveness of antitumor immune responses, even in context immunotherapies. However, it is observed pathogenic microorganisms can trigger strong responses during infection, offering a potential means to counteract environment tumors. In this study, protein nanocage called CpG@HBc nanocages (NCs) developed, which mimics structure hepatitis B virus and combines with an immunostimulatory component...
Protein cages have played a long-standing role in biomedicine applications, especially tumor chemotherapy. Among protein cages, virus like particles (VLPs) received attention for their potential applications vaccine development and targeted drug delivery. However, most of the existing protein-based platform technologies are plagued with immunological problems that may limit systemic delivery efficiency as carriers. Here, we show using immune-orthogonal sequentially modifying dominant loop...
Abstract Therapeutic cancer vaccines have the potential to induce regression of established tumors, eradicate microscopic residual lesions, and prevent metastasis recurrence, but their efficacy is limited by low antigenicity soluble antigens immunosuppressive tumor‐associated macrophages (TAMs) that promote tumor growth. In this study, a novel strategy reported for overcoming these defenses: dual‐targeting nano‐vaccine (NV) based on hepatitis B core antigen (HBcAg) derived virus‐like...
Detailed chemical investigation of the herb Sarcopyramis bodinieri var. delicate resulted in isolation two new flavonol glycosides, namely, isorhamnetin-3-O-(6′′-OE- feruloyl)-β-D-glucopyranoside (1) and isorhamnetin-3-O-(6′′-O-E-feruloyl)-β-Dgalactopyranoside (2). In addition, four known compounds, quercetin-3-O-(6′′-acetyl)-β-Dglucopyranoside (3), isorhamnetin-3-O-(6′′-acetyl)-β-D-glucopyranoside (4), quercetin-3- O-(6′′-O-E-p-coumaroyl)-β-D-glucopyranoside (5),...