A5031306791- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Respiratory and Cough-Related Research
- Intensive Care Unit Cognitive Disorders
- Pulmonary Hypertension Research and Treatments
- Cardiovascular and exercise physiology
- Delphi Technique in Research
- Material Science and Thermodynamics
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Transplantation: Methods and Outcomes
- Nuclear reactor physics and engineering
- Nursing Diagnosis and Documentation
- Exercise and Physiological Responses
- Nuclear Materials and Properties
- Long-Term Effects of COVID-19
- Polyomavirus and related diseases
- Nuclear Physics and Applications
- Inhalation and Respiratory Drug Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hematopoietic Stem Cell Transplantation
Istituti Clinici Scientifici Maugeri
1995-2022
Pulmonary Associates
2017
Fondazione Salvatore Maugeri
1998-2015
Istituti di Ricovero e Cura a Carattere Scientifico
1995-2015
Centro Clinico Nemo
1989-1997
Policlinico San Matteo Fondazione
1997
University of Pavia
1985-1992
The aim of our study was to measure values maximal inspiratory (MIP) and expiratory (MEP) mouth pressures in 625 (266 male, 359 female) clinically functionally normal subjects drawn out a sample representative the general population. MEP (near TLC FRC) found be significantly higher when compared with MIP RV FRC), male were than those female subjects. at FRC closely related, as near FRC. Among tested body-size variables, body surface area (BSA) for all parameters had highest degree...
The aim of this study was to evaluate whether pressure support ventilation (PSV) requires different diaphragmatic efforts and patient-ventilator matching, according the underlying disease. Four groups patients requiring PSV were studied: Group A, recovering from an episode acute respiratory failure due adult distress syndrome (ARDS); B, with postsurgical complications; two subsets chronic obstructive pulmonary disease (COPD) patients, "normal" static compliance system (Cst,rs) (Group C) or...
We studied survival and failure or success of weaning from mechanical ventilation (MV) in 42 consecutive chronic obstructive pulmonary disease (COPD) patients requiring prolonged MV (more than 21 days) after an episode acute respiratory admission to our Intermediate Intensive Care Unit (IICU). Parameters including arterial blood gases, function tests, muscle force, neuromuscular drive, nutritional status were recorded during a phase clinical stability, order identify the features related...
Abstract: In addition to clinical comorbidities, psychological and neuropsychological problems are frequent in COPD may affect pulmonary rehabilitation delivery outcome. The aims of the study were describe a population rehabilitative setting as regards patients depressive symptoms, anxiety, mild cognitive impairment (MCI) self-reported adherence analyze their relationships; compare sample MCI scores with normative data; investigate which factors might predict prescribed physical exercise....
Erectile dysfunction (ED) is common in men with obstructive sleep apnea (OSAS) but no completely convincing hypotheses about the underlying pathogenic mechanisms have been published literature. The aims of present study were to assess presence ED a group OSAS patients without daytime respiratory failure and determine whether this was related peripheral nerve involvement. Evaluation bulbocavernosus reflex (BCR) somato-sensory evoked potentials pudendal (PSEPs), most widely established method...
BACKGROUND: The effect of the type trigger system on inspiratory effort has been studied in intubated patients, but no data are available non-invasive mechanical ventilation where "trigger variable" may be even more important since assisted modes often employed from beginning ventilation. METHODS: flow triggering (1 and 5 1/min) pressure (-1 cm H2O) during support (PSV) controlled mode (A/C) delivered non-invasively with a full face mask were compared patients chronic obstructive pulmonary...
Background: Fat-free mass (FFM) depletion marks the imbalance between tissue protein synthesis and breakdown in chronic obstructive pulmonary disease (COPD).To date, role of essential amino acid supplementation (EAAs) FFM repletion has not been fully acknowledged.A pilot study was undertaken patients attending rehabilitation.Methods: 28 COPD with dynamic weight loss 5% over last 6 months were randomized to receive EAAs embedded a 12-week rehabilitation program (EAAs group n = 14), or same...
It is uncertain whether exposure to renin-angiotensin system (RAS) modifiers affects the severity of new coronavirus disease 2019 (COVID-19) because most available studies are retrospective.We tested prognostic value RAS (either angiotensin-converting enzyme inhibitors [ACE-Is] or angiotensin receptor blockers [ARBs]) in a prospective study hypertensive patients with COVID-19. We analyzed data from 566 (mean age 75 years, 54% males, 162 ACE-Is users, and 147 ARBs users) hospitalized five...
Recipients of heart-lung transplantation (HLT) show reduced exercise capacity due to several pre- and postsurgical factors. The aim this study was evaluate the time course capacity, skeletal respiratory muscle performance in 11 patients (5 females 6 males; age (mean +/- SD) 38 13 yrs) undergoing HLT. All were admitted our institution for a rehabilitation programme after surgery, followed-up 18 months. On admission, at discharge an in-patient programme, every months, underwent evaluation of:...
The relationship between smoking habits and airway responsiveness has been studied in a cross-sectional sample of subjects small Lombardy (Italy) town. were 15 64 yr age; they representative the general population. There 295 normal nonsmokers, 70 smokers, 50 past smokers. All clinically asymptomatic functionally underwent methacholine challenge. distribution to (as expressed by LnPD15FEV1) was found be significantly different these smokers nonsmokers. A multinomial logistic regression model...
Patient selection criteria and experimental interventions of randomized controlled trials may not reflect how things work in practice. The aim this study was to describe the characteristics chronic obstructive pulmonary disease (COPD) patients undergoing an inpatient rehabilitation program (PRP) correlates success. Retrospective database review 975 consecutive transferred from acute care hospitals after exacerbation (group A: 14.6%) or admitted home B: 75.4%), 2010 2017. Patients were also...
Introduction Chronic obstructive pulmonary disease (COPD) is a complex multi-component disorder characterized by progressive irreversible respiratory symptoms and extrapulmonary comorbidities, including anxiety-depression mild cognitive impairment (MCI). However, the prevalence of these impairments still uncertain, due to non-optimal screening methods. This observational cross-sectional multicentre study aimed evaluate anxiety-depressive MCI in COPD patients, identify most appropriate tests...
Aimsheart failure (HF) and coronary artery disease (CAD) are independent predictors of death in patients with COVID-19. The adverse prognostic impact the combination HF CAD these is unclear.Methods resultswe analysed data from 954 consecutive hospitalized for SARS-CoV-2 five Italian Hospitals February 23 to May 22, 2020. study was a systematic prospective collection according pre-specified protocol. All-cause mortality during hospitalization outcome measure.Mean duration 33 days. Mortality...
Recently, to reduce the costs of polysomnography, split-night studies have been introduced into routine practice: first part night is used make diagnosis obstructive sleep apnoea syndrome (OSAS) and second achieve an appropriate level continuous positive airway pressure. Since this protocol has not yet validated by comparison polysomnographic pictures obtained in parts night, aim study was evaluate profile respiratory disturbances (PSG1) (PSG2) portion a standard full-night examination...
The term connective tissue diseases (CTD) defines a group of illnesses characterized by the presence immune abnormalities and widespread inflammation involving various organs tissues including lung. These are not frequent in paediatric age group. Very few data on pulmonary function available CTD. We investigated possible early lung any likely relationship with clinical activity disease 81 CTD patients, without or radiological evidence involvement. Measurement volumes diffusion capacity were...
<b><i>Background:</i></b> After undergoing a procedure of pulmonary endarterectomy (PEA), patients with chronic thromboembolic hypertension (CTEPH) may still experience reduced exercise capacity. Data on effects training in these are scant. <b><i>Objectives:</i></b> To evaluate the effectiveness after PEA for CTEPH and if presence “residual hypertension” affect outcome. <b><i>Methods:</i></b> Retrospective data analysis...
Nocturnal oxygen desaturations (NOD), especially during REM sleep, have been described in patients with COPD. However, the role of NOD evolution COPD to chronic respiratory failure has not well studied.The aim our study was evaluate whether is a risk factor for development patients.We studied 34 consecutive stable daytime PaO(2) >60 mm Hg over period 42 months. We classified as desaturators (NOD) when episodic were found mainly independently baseline SaO(2) values.At enrollment 19 (55.8%)...
Objectives: To explore the mediating role of protein interleukin-6 (IL-6) on relationship between forced expiratory volume in 1 second (FEV ) and 6-minute walk distance (6MWD) and, further, to determine whether status variables (such as age, sex, body mass index [BMI]) operate moderators this mediation relationship. Design: Moderated model. Setting: An inpatient pulmonary rehabilitation center Italy. Participants: All 153 patients involved screening a randomized controlled clinical trial...