A5086411091- Chronic Obstructive Pulmonary Disease (COPD) Research
- Smoking Behavior and Cessation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Asthma and respiratory diseases
- Nosocomial Infections in ICU
- Family and Patient Care in Intensive Care Units
- Eosinophilic Disorders and Syndromes
- Palliative Care and End-of-Life Issues
- Biochemical and Structural Characterization
- Cardiac Health and Mental Health
- Childhood Cancer Survivors' Quality of Life
- Pediatric health and respiratory diseases
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Obstructive Sleep Apnea Research
- Long-Term Effects of COVID-19
- Cardiovascular Function and Risk Factors
- Obesity, Physical Activity, Diet
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- COVID-19 Clinical Research Studies
- Air Quality and Health Impacts
- Antimicrobial Peptides and Activities
- Fractal and DNA sequence analysis
Istituti Clinici Scientifici Maugeri
2003-2022
Clinica de Pneumologie Iaşi
2018
Fondazione Salvatore Maugeri
2005-2016
Istituti di Ricovero e Cura a Carattere Scientifico
2005-2015
University of Pavia
2005
A few studies have assessed the short-term effects of low-dose nicotine e-cigarettes, while data about nicotine-free e-cigarettes (NF e-cigarettes) are scanty. Concerns been expressed use NF because high concentrations propylene glycol and other compounds in e-cigarette vapor. This laboratory-based study was aimed to compare ad libitum a or traditional cigarette for 5 min healthy adult smokers (n = 10) non-smokers 10). The main outcome measures were pulmonary function tests, fraction exhaled...
The chemokine receptors CXCR3 and CCR4 have recently been described as playing a pivotal role in the mouse model of bleomycin-induced fibrosis.To evaluate these human idiopathic pulmonary fibrosis (IPF).We studied 57 patients: 18 with IPF, 17 non-IPF (nIPF), 12 sarcoidosis, 10 healthy control subjects.We evaluated expression blood bronchoalveolar lavage (BAL) T lymphocytes by flow cytometry CXCL10, CXCL11 CCL17 BAL concentration singular immunoassay.Patients IPF had significantly lower...
Discussion about patients' end-of-life (E-o-L) preferences should be part of the routine practice. Using a semi-structured interview with scenario-based decision, we performed prospective multicentre study to elicit E-o-L in very severe chronic obstructive pulmonary disease (COPD). We also checked their ability retain this information and respect decisions when they die. Forty-three out ninety-one eligible patients completed study. The choice practice was equally distributed among three...
It is uncertain whether exposure to renin-angiotensin system (RAS) modifiers affects the severity of new coronavirus disease 2019 (COVID-19) because most available studies are retrospective.We tested prognostic value RAS (either angiotensin-converting enzyme inhibitors [ACE-Is] or angiotensin receptor blockers [ARBs]) in a prospective study hypertensive patients with COVID-19. We analyzed data from 566 (mean age 75 years, 54% males, 162 ACE-Is users, and 147 ARBs users) hospitalized five...
Aimsheart failure (HF) and coronary artery disease (CAD) are independent predictors of death in patients with COVID-19. The adverse prognostic impact the combination HF CAD these is unclear.Methods resultswe analysed data from 954 consecutive hospitalized for SARS-CoV-2 five Italian Hospitals February 23 to May 22, 2020. study was a systematic prospective collection according pre-specified protocol. All-cause mortality during hospitalization outcome measure.Mean duration 33 days. Mortality...
Alpha1-antitrypsin deficiency (AATD) is a common hereditary disorder associated with high risk of developing pulmonary emphysema early in life and, to lesser extent, chronic liver disease and cirrhosis. Among Northern Europeans Americans, more than 95% individuals AATD carry the most frequent AAT deficient gene variants, PI*Z PI*S. Rare variants account for 2-4% individuals. We extend sequence data on by characterizing novel Null allele detected 3 subjects: carrier belonging an...
A 73-year-old never-smoker woman with chronic bronchitis, increasing dyspnoea, and airflow limitation a FEV1 of 49% predicted value had low serum level alpha-1-antitrypsin (69 mg/dL, normal range 150-350). Isoelectric focusing showed an Mlike pattern. Direct sequencing showed, in the second exon, particular DNA alteration localized between codon 41 51: region 30 base pairs (bp) was completely deleted substituted by 22-bp sequence. The resulting loss 8 bp yields, 70-71 stop codon. This new...
Background and objective: Idiopathic pulmonary fibrosis (IPF) is a chronic irreversible interstitial lung disease whose diagnosis often requires surgical biopsies (SLB) in cases without consistent radiological findings. We previously published that the expression of chemokine receptors CXCR3 CCR4 on T cells significantly different bronchoalveolar lavage (BAL) IPF patients from other diseases. The aim study was to evaluate cut-off values expressed peripheral blood (PB) useful for differential...
<b>Background:</b> The coexistence of obstructive sleep apnea syndrome (OSAS) and chronic pulmonary disease (COPD), namely overlap (OS), is associated with high morbidity, exacerbation rate mortality. Data on its prevalence are conflicting clear screening recommendations still lacking; however a BMI<35 an ESS<10 often used to exclude OSAS in practice. <b>Aims:</b> To evaluate the series patients COPD admitted Pulmonary Rehabilitation centre. <b>Methods:</b> 422 consecutive were...