A5020668641- Liver physiology and pathology
- Trace Elements in Health
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Cellular Mechanics and Interactions
- Drug-Induced Hepatotoxicity and Protection
- Metabolism and Genetic Disorders
- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Cell death mechanisms and regulation
- Thyroid Cancer Diagnosis and Treatment
- Chromosomal and Genetic Variations
- Organ Transplantation Techniques and Outcomes
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Heavy Metal Exposure and Toxicity
- Caveolin-1 and cellular processes
- Endoplasmic Reticulum Stress and Disease
- Reproductive biology and impacts on aquatic species
- Carcinogens and Genotoxicity Assessment
- Peptidase Inhibition and Analysis
- Colorectal Cancer Treatments and Studies
- Fish Biology and Ecology Studies
- Protease and Inhibitor Mechanisms
University of Cagliari
2015-2024
Pathological Society
2021
Anthrologica
2012
United States Nuclear Regulatory Commission
2012
Nuovo Ospedale San Giovanni di Dio
2009
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
1996
KU Leuven
1996
University of Toronto
1989
Istituto di Farmacologia Traslazionale
1987
Thymosin β4 (Tβ4) was extracted forty years agofrom calf thymus. Since then, it has been identified as a G-actin binding protein involved in blood clotting, tissue regeneration, angiogenesis, and anti-inflammatory processes. Tβ4 also implicated tumor metastasis neurodegeneration. However, the precise roles mechanism(s) of action these processes remain largely unknown, with being insufficient to explain multi-actions. Here we identify for first time important role mechanism ferroptosis, an...
Breast milk represents the gold standard for neonatal nutrition, especially preterm and term infants with a low birthweight. This awareness is based not only on nutritional properties of human milk, which specifically designed growth humans but also breast milk’s non-nutritional properties, such as protection against infection. In fact, should be considered heterogeneous ecosystem, including wide range cells in addition to those involved immune function; factors, vascular endothelial factor;...
Objective Thymosin β-4 (Tβ4) is a ubiquitous peptide that plays pivotal roles in the cytoskeletal system and cell differentiation during embryogenesis. Recently, role for Tβ4 has been proposed experimental human carcinogenesis. This study was aimed at evaluating correlation between immunoractivity colorectal cancer, with particular attemption to tumor cells undergoing epithelial-mesenchymal transition.Methods Results 86 intestinal biopsies were retrospectively analyzed including 76...
The steady-state levels of c-fos, c-jun and c-myc messenger RNA were investigated in rat liver tissue after proliferative stimuli different nature-namely, compensatory regeneration induced by partial hepatectomy or carbon tetrachloride administration-and direct hyperplasia four hepatomitogens: lead nitrate, ethylene dibromide, cyproterone acetate nafenopin. We show here that whereas c-fos expression increased soon administration, an the absence occurred during nitrate dibromide. When was...
Journal Article Ploidy and nuclearity of rat hepatocytes after compensatory regeneration or mitogen-induced liver growth Get access Cinzia Melchiorri, Melchiorri 1Istituto di Oncologia 'F.Addari', Ospedale S.OrsolaBologna, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Pasquale Chieco, Chieco Antonio Ignazio Zedda, Zedda Pierpaolo Coni, Coni Giovanna Maria Ledda-Columbano, Ledda-Columbano Amedeo Columbano 2 2To whom correspondence should be addressed...
Journal Article Enhancement of cholesterol synthesis and pentose phosphate pathway activity in proliferating hepatocyte nodules Get access Giovanna M. Ledda-Columbano, Ledda-Columbano 1 Istituto di Farmacologia e Patologia Biochimica, University CagliariVia Porcell 4, 09100 Cagliari, Italy To whom reprint requests should be sent Search for other works by this author on: Oxford Academic PubMed Google Scholar Amedeo Columbano, Columbano Sandra Dessì, Dessì Pierpaolo Coni, Coni Caterina...
Pistacia lentiscus berry oil (LBO) represents a typical vegetal product of the Mediterranean basin that has been formally used in traditional cuisine for 100s years. In addition to its interesting alimentary properties, this could represent an candidate field research on study new anti-infective agents. fact, countries, lentisk still continues be widely folk medicine oral and skin affections, particular, acute gingivitis, pediatric infections such as impetigo foot plaques, biofilm related...
Journal Article Failure of mitogen-induced cell proliferation to achieve initiation rat liver carcinogenesis Get access Amedeo Columbano, Columbano 1 Istituto di Farmacologia e Patologia Biochimica, Universita Cagliari, Via Porcell 4, 09100, Italy To whom reprint requests should be sent Search for other works by this author on: Oxford Academic PubMed Google Scholar Glovanna M. Ledda-Columbano, Ledda-Columbano Pierpaolo Coni, Coni Paolo Pani Carcinogenesis, Volume 8, Issue 2, February 1987,...
ATP7B is a copper transporting P-type ATPase, also known as Wilson disease protein, which plays key role in distribution inside cells. Recent experimental data cell culture have shown that putatively serves dual function hepatocytes: when localized to the Golgi apparatus, it has biosynthetic role, delivering atoms apoceruloplasmin; hepatocytes are under stress, translocates biliary pole transport excess out of and into bile canaliculus for subsequent excretion from body via bile. The above...
Due to its actin-sequestering properties, thymosin beta-4 (Tβ4) is considered play a significant role in the cellular metabolism. Several physiological properties of Tβ4 have been reported;, however, many questions concerning function remain be ascertained. To better understand this small peptide we analyzed by means transmission immunoelectron microscopy techniques ultrastructural localization HepG2 cells. Samples cells were fixed mixture 3% formaldehyde and 0.1% glutaraldehyde 0.1 M...
The incidence of node metastases in papillary thyroid carcinoma (PTC) is high, ranging from 20% to 90%. Prophylactic central lymph compartment dissection (CLND), suggested the latest guidelines for high-risk tumors, meets resistance due high postoperative complications. Recently, new molecular biologic techniques, such as One Step Nucleic Acid Amplification (OSNA), have spread widely, allowing quickly isolate, amplify and quantify mRNA encoding proteins selectively present neoplastic cells,...
Experiments were designed to investigate the expression of three cell-cycle-dependent proto-oncogenes in response two different types proliferative stimuli: compensatory cell proliferation after partial hepatectomy (PH) or CCl4 and liver hyperplasia induced by mitogens ethylene dibromide (EDB) cyproterone acetate (CPA). Steady-state levels messenger RNAs for c-fos c-myc found be elevated PH with a maximum increase between 0.5 2 h at 2-3 rapid decline 3 h. However, when was mitogens, no mRNA...
Our earlier studies have revealed that direct hyperplasia induced by liver mitogens such as lead nitrate, ethylene dibromide, nafenopin and cyproterone acetate, unlike compensatory cell proliferation partial hepatectomy CCl4, does not support the formation of enzyme-altered islands chemical carcinogens in liver. In previous were given at peak DNA synthesis mitogens. If altered sensitive phase hepatocyte to carcinogenic attack, administering carcinogen one time point following mitogenic...