Kacper Szczepski

ORCID: 0000-0003-1038-3538
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About
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Research Areas
  • Metabolomics and Mass Spectrometry Studies
  • Chemical Synthesis and Analysis
  • Epigenetics and DNA Methylation
  • Ubiquitin and proteasome pathways
  • Protein Structure and Dynamics
  • NMR spectroscopy and applications
  • Caveolin-1 and cellular processes
  • Ferroptosis and cancer prognosis
  • Advanced MRI Techniques and Applications
  • Genomics and Chromatin Dynamics
  • Cancer-related gene regulation
  • Silicon Nanostructures and Photoluminescence
  • Cancer, Lipids, and Metabolism
  • Biotin and Related Studies
  • Cancer, Hypoxia, and Metabolism
  • Iron Metabolism and Disorders
  • Molecular Junctions and Nanostructures
  • Plant Stress Responses and Tolerance
  • Antimicrobial Peptides and Activities
  • Signaling Pathways in Disease
  • Histone Deacetylase Inhibitors Research
  • Nutrition, Genetics, and Disease
  • Pharmacogenetics and Drug Metabolism
  • Advanced NMR Techniques and Applications
  • Plant nutrient uptake and metabolism

King Abdullah University of Science and Technology
2019-2025

University of Wrocław
2020-2025

Nitric oxide (NO) functions as a signaling molecule in plant adaptation to changing environmental conditions. NO levels were found increase plants response low temperatures (LTs). However, knowledge of the pathways involved enhanced production under cold stress is still limited. For this reason, we aimed determine role different sources generation cucumber roots exposed 10 °C for short (1 d) and long (6 periods. The short-term treatment seedlings with LT markedly increased plasma...

10.3390/ijms26041599 article EN International Journal of Molecular Sciences 2025-02-13

Thymosin β4 (Tβ4) was extracted forty years agofrom calf thymus. Since then, it has been identified as a G-actin binding protein involved in blood clotting, tissue regeneration, angiogenesis, and anti-inflammatory processes. Tβ4 also implicated tumor metastasis neurodegeneration. However, the precise roles mechanism(s) of action these processes remain largely unknown, with being insufficient to explain multi-actions. Here we identify for first time important role mechanism ferroptosis, an...

10.3390/ijms23010551 article EN International Journal of Molecular Sciences 2022-01-04

The unique photophysical properties of single-walled carbon nanotubes (SWCNTs) exhibit great potential for bioimaging applications. This led to extensive exploration photosensitization methods improve their faint shortwave infrared (SWIR) photoluminescence. Here, we report the mechanisms SWCNT-assisted J-aggregation cyanine dyes and associated photoluminescence enhancement SWCNTs in SWIR spectral region. Surprisingly, found that excitation energy transfer between makes a negligible...

10.1021/acsomega.4c00240 article EN cc-by ACS Omega 2024-03-26

Lasso peptides are unique in that the tail of lasso peptide threads through its macrolactam ring. The unusual structure and biological activity have generated increased interest from scientific community recent years. Because this, many new types been discovered. These can be synthesized by microorganisms efficiently, yet, their chemical assembly is challenging. Herein, we investigated possibility high pressure inducing cyclization linear precursors peptides. Unlike other molecules like...

10.1371/journal.pone.0234901 article EN cc-by PLoS ONE 2020-06-24

Chromatin marks are recognized by distinct binding modules, many of which embedded in multidomain proteins. How the different functionalities such complex chromatin modulators regulated is often unclear. Here, we delineated interplay H3 amino terminus– and K9me-binding activities hUHRF1 protein. We show that phosphoinositide PI5P interacts simultaneously with two distant flexible linker regions connecting domains hUHRF1. The dependent on both, polar head group, acyl part phospholipid induces...

10.1126/sciadv.abl9461 article EN cc-by-nc Science Advances 2022-08-24

Abstract Thymosin β4 (Tβ4) was extracted forty years ago 1 from calf thymus. Since then, it has been identified as a G-actin binding protein involved in blood clothing, tissue regeneration, angiogenesis, and anti-inflammatory processes. Tβ4 also implicated tumor metastasis neurodegeneration. However, the precise roles mechanism(s) of action these processes remain largely unknown, with being insufficient to explain multi-actions. Here we identify for first time important part mechanism...

10.21203/rs.3.rs-677051/v1 preprint EN cc-by Research Square (Research Square) 2021-07-09
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