A5079337203- Cellular Mechanics and Interactions
- Chromosomal and Genetic Variations
- Infant Nutrition and Health
- Liver physiology and pathology
- Reproductive biology and impacts on aquatic species
- Animal Genetics and Reproduction
- Neonatal Respiratory Health Research
- Fish Biology and Ecology Studies
- DNA and Nucleic Acid Chemistry
- Drug Transport and Resistance Mechanisms
- Genetic diversity and population structure
- Identification and Quantification in Food
- Trace Elements in Health
- X-ray Diffraction in Crystallography
- Caveolin-1 and cellular processes
- Fish Ecology and Management Studies
- Nuclear Structure and Function
- Heat shock proteins research
- Epigenetics and DNA Methylation
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- Advanced Proteomics Techniques and Applications
- Neuroblastoma Research and Treatments
- Aquaculture Nutrition and Growth
- Genomics and Phylogenetic Studies
University of Cagliari
2015-2024
Surgical Science (Sweden)
2024
Pathological Society
2021
Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari
2009
University of Toronto
1988-1993
Thymosin β4 (Tβ4) was extracted forty years agofrom calf thymus. Since then, it has been identified as a G-actin binding protein involved in blood clotting, tissue regeneration, angiogenesis, and anti-inflammatory processes. Tβ4 also implicated tumor metastasis neurodegeneration. However, the precise roles mechanism(s) of action these processes remain largely unknown, with being insufficient to explain multi-actions. Here we identify for first time important role mechanism ferroptosis, an...
Breast milk represents the gold standard for neonatal nutrition, especially preterm and term infants with a low birthweight. This awareness is based not only on nutritional properties of human milk, which specifically designed growth humans but also breast milk’s non-nutritional properties, such as protection against infection. In fact, should be considered heterogeneous ecosystem, including wide range cells in addition to those involved immune function; factors, vascular endothelial factor;...
Pistacia lentiscus berry oil (LBO) represents a typical vegetal product of the Mediterranean basin that has been formally used in traditional cuisine for 100s years. In addition to its interesting alimentary properties, this could represent an candidate field research on study new anti-infective agents. fact, countries, lentisk still continues be widely folk medicine oral and skin affections, particular, acute gingivitis, pediatric infections such as impetigo foot plaques, biofilm related...
Due to its actin-sequestering properties, thymosin beta-4 (Tβ4) is considered play a significant role in the cellular metabolism. Several physiological properties of Tβ4 have been reported;, however, many questions concerning function remain be ascertained. To better understand this small peptide we analyzed by means transmission immunoelectron microscopy techniques ultrastructural localization HepG2 cells. Samples cells were fixed mixture 3% formaldehyde and 0.1% glutaraldehyde 0.1 M...
Experiments were designed to investigate the expression of three cell-cycle-dependent proto-oncogenes in response two different types proliferative stimuli: compensatory cell proliferation after partial hepatectomy (PH) or CCl4 and liver hyperplasia induced by mitogens ethylene dibromide (EDB) cyproterone acetate (CPA). Steady-state levels messenger RNAs for c-fos c-myc found be elevated PH with a maximum increase between 0.5 2 h at 2-3 rapid decline 3 h. However, when was mitogens, no mRNA...
Two new fluorescent squaramides bearing quinoline (<bold>L1</bold>) and naphthalene (<bold>L2</bold>) as fluorogenic fragments were synthesized investigated possible cellular imaging probes free molecules when loaded in monoolein-based cubosomes.
Manganese excess can induce in humans neurological disorders known as manganism.
The lactating mammary gland contains a stem cells population with multilineage potentialities. Recently it was also shown that breast milk heterogeneous of have the potential to differentiate in vitro, under control specific differentiation conditions, into epithelial as well adipogenic, chondrogenic and osteogenic cell lineages. While different types present is known, what less understood proportion types, their significance for mother infant factors influencing them.In this manuscript we...
Recent findings of stem/progenitor cells in maternal milk and their ability to cross the intestinal barrier lactating newborns integrate into neonatal organs promote optimal child development present a new challenge perinatal medicine. These emphasize need for all mothers breastfeed babies long time. According recent research, breastfeeding protects newborn from multiple infectious agents that can cause severe fatal early infancy diseases. The second benefit is stem accelerate several...
Breakthrough studies have shown that pluripotent stem cells are present in human breast milk. The expression of pluripotency markers by milk is heterogeneous, relating to cellular hierarchy, from early-stage multi-lineage fully differentiated mammary epithelial cells, as well weeks gestation and days lactation.Here, we qualitatively analyze cell marker freshly isolated without any manipulation could influence protein expression. Moreover, use electron microscopy investigate cell-cell...
We studied possible molecular and cytological correlations between the European (Anguilla anguilla) American rostrata) eel, using either low weight highly repetitive sequences isolated from genomic DNA of two species, or conserved sequences, such as 45S 5S rDNA, probes. A clearcut difference was found only in filter hybridization experiments carried out rDNA probe.Key words: fish, chromosomes, DNA, endonucleases, rDNA.
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The finding of stem/progenitor cells in the maternal milk and discovery their multilineage potential, associated with some evidence regarding ability to cross gastrointestinal barrier integrate into organs breastfed neonate, has opened an intriguing debate, strict relationship between mother son postnatal period. In particular, thanks presence high quantities mammary stem cells, a new vision is emerging, which breastfeeding appears as unique occasion for reinforcing physiological development...
Biomarkers of cell stress are important for proper diagnosis, and in studies how cells respond to drug treatment. that early pharmacological treatment could improve therapy by tailoring the needs patient. Thymosin beta-4 (Tβ4) plays a significant role many aspects cellular metabolism because its actin-sequestering properties. Other physiological functions Tβ4 have been also reported. Among these, may play crucial during stress. We addressed relevance conditions using different treatments...
In recent decades, type 2 diabetes complications have been correlated with amylin aggregation, copper homeostasis and metformin side effects. However, each factor was analyzed separately, only in some rare cases copper/amylin or copper/metformin complexes were considered. We demonstrate for the first time that binary metformin/amylin tertiary (II)/amylin/metformin of high cellular toxicity are formed lead to formation aggregated multi-level lamellar structures on cell membrane. Considering...
We have studied fixed chromosomes and purified DNA of Anguilla anguilla L. after digestion with HaeIII, AluI, MboI, DdeI restriction endonucleases. Our data demonstrated (i) confirmation the heteromorphic nature NORs, (ii) absence detectable sex chromosomes, (iii) presence discrete intercalary domains in this species. also permitted us to hypothesize existence highly repetitive DNAs, localized specific heterochromatic regions A. chromosomes.Key words: fish, DNA, enzymes.
Muraenidae is a species-rich family, with relationships among genera and species taxonomy that have not been completely clarified. Few cytogenetic studies conducted on this all of them showed the same diploid chromosome number (2n=42) but conspicuous karyotypic variation species. The Mediterranean moray eel Gymnothorax unicolor was previously cytogenetically studied using classical techniques allowed characterization its karyotype structure constitutive heterochromatin argyrophilic nucleolar...
In recent years the presence of stem cells (hBSCs: human breastmilk-derived cells) and epithelial progenitors has been demonstrated in mother’s milk (MM). Stem present samples fresh MM exhibit a high degree vitality this makes possible performance cell cultures to evaluate differentiation capacity hBSCs. The most important datum that expresses enormous potential use is population capable differentiating into three mesoderm, endoderm ectoderm lines. small number studies analyzed different...