A5080499096- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Airway Management and Intubation Techniques
- Ultrasound in Clinical Applications
- Intensive Care Unit Cognitive Disorders
- Spinal Cord Injury Research
- Trauma and Emergency Care Studies
- Family and Patient Care in Intensive Care Units
- Neonatal Respiratory Health Research
- Radiology practices and education
- Obstructive Sleep Apnea Research
- Nosocomial Infections in ICU
- Sepsis Diagnosis and Treatment
- Radiation Dose and Imaging
- Spinal Fractures and Fixation Techniques
- Botulinum Toxin and Related Neurological Disorders
- Transplantation: Methods and Outcomes
- Musculoskeletal pain and rehabilitation
- Hemodynamic Monitoring and Therapy
- Neurogenetic and Muscular Disorders Research
- Mechanical Circulatory Support Devices
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Thermal Regulation in Medicine
- Cardiovascular and Diving-Related Complications
St. Michael's Hospital
2020-2025
University of Toronto
2020-2025
Muscular Dystrophy Canada
2024
Unity Health Toronto
2022-2024
St Michaels Hospital
2023
Fondazione Salvatore Maugeri
2011-2022
University Health Network
2019
Istituti Clinici Scientifici Maugeri
2011-2019
Assistance Publique – Hôpitaux de Paris
2016-2019
Pitié-Salpêtrière Hospital
2016-2019
In a physiological randomised cross-over study performed in stable hypercapnic chronic obstructive disease patients, we assessed the short-term effects of two settings noninvasive ventilation. One setting was aimed at maximally reducing arterial carbon dioxide tension (P(a,CO(2))) (high-intensity (Hi) positive pressure ventilation (NPPV)): mean ± SD 27.6 2.1 cmH(2)O inspiratory airway pressure, 4 0 expiratory and respiratory rate 22 breaths · min(-1). The other according to usual parameters...
High-flow nasal cannula generates positive airway pressure and reduces respiratory rate. Our findings confirm these physiological effects when the mouth is kept closed. An increased resistance to breathing induces a longer expiratory phase, which leads decreased rate minute ventilation, therefore workload, counterbalancing pressure-time product per liter. These are less apparent with open not observed continuous pressure.
<h3>BACKGROUND:</h3> Patients undergoing prolonged mechanical ventilation represent up to 15% of all patients requiring weaning from ventilation. Although recent guidelines have recommended including physiotherapy early during speed the process weaning, only indirect evidence supporting use is available for receiving The aim our study was evaluate effects a program in subjects and correlates successful weaning. <h3>METHODS:</h3> A retrospective analysis performed on 1,313 consecutive...
The aim of our study was to evaluate the prevalence and predictors obstructive sleep apnea (OSA) in patients with chronic pulmonary disease (COPD) undergoing inpatient rehabilitation programs (PRPs). A retrospective data review consecutive stable a known diagnosis COPD, admitted for PRP between January 2007 December 2013. Full overnight polysomnography (PSG) Epworth Sleepiness Scale (ESS) were assessed all patients. Out 422 evaluated patients, 190 (45%) showed an Apnea Hypopnea Index (AHI) ≥...
Non invasive ventilation (NIV) is currently employed for weaning from (IMV) in the acute setting but its use prolonged still occasional and not standardized. We wanted to evaluate whether a combined protocol of NIV decannulation tracheostomized patients needing mechanical was feasible what would be one-year outcome.We studied dependent with following inclusion criteria: a) tolerance at least 8h unsupported breathing, b) progressive hypercapnia/acidosis after discontinuation, c) good...
Abstract Objectives To evaluate the accuracy of a new COVID‐19 prognostic score based on lung ultrasound (LUS) and previously validated variables in predicting critical illness. Methods We conducted single‐center retrospective cohort development internal validation study Worsening Score (COWS), combination COVID‐GRAM (GRAM) LUS. Adult patients admitted to emergency department (ED) were enrolled. Ten identified by GRAM, days from symptom onset, LUS findings, peripheral oxygen...
Abstract Background Predicting complete liberation from mechanical ventilation (MV) is still challenging. Electrical impedance tomography (EIT) offers a non-invasive measure of regional distribution and could bring additional information. Research question. Whether the display during Spontaneous Breathing Trial (SBT) help at predicting early successful MV. Study design methods Patients were monitored with EIT SBT. The tidal image was divided into ventral dorsal regions displayed...
Abstract Rationale There are several approaches to select the optimal positive end-expiratory pressure (PEEP), resulting in different PEEP levels. The impact of settings may extend beyond respiratory mechanics, affecting pulmonary hemodynamics. Objectives To compare levels obtained with three titration strategies—(i) highest system compliance (C RS ), (ii) electrical impedance tomography (EIT) crossing point; (iii) transpulmonary (P L )—in terms regional mechanics and Methods Experimental...
Abstract Background Lung ultrasonography (LUS) is a non-invasive imaging method used to diagnose and monitor conditions such as pulmonary edema, pneumonia, pneumothorax. It precious where other techniques like CT scan or chest X-rays are of limited access, especially in low- middle-income countries with reduced resources. Furthermore, LUS reduces radiation exposure its related blood cancer adverse events, which particularly relevant children young subjects. The score obtained allows...
<h3>BACKGROUND:</h3> The value of ultrasound in assessing lung aeration patients with ARDS who require venovenous extracorporeal membrane oxygenation (ECMO) has, to our knowledge, never been studied. objective the study was evaluate by using at ECMO initiation and withdrawal subjects severe supported ECMO. <h3>METHODS:</h3> Fifty were included this pilot retrospective study. score (LUS) respiratory variables collected (T0) (T1). LUS T0 between survived ICU discharge those died compared....
Background: ALS patients should discuss the issue of tracheostomy before onset terminal respiratory failure. While process shared decision-making is desirable, there are few data on practical application this real-life situation.Aim study: To determine how a actually carried out, we analysed episodes acute failure preceding tracheostomy.Methods: We studied charts group after tracheostomy. An interview focusing existence anticipated directives was out. Tracheostomies were classified as...
Abstract Coronavirus disease 2019 (COVID‐19) has created unprecedented disruption for global healthcare systems. Offices and emergency departments (EDs) were the first responders to pandemic, followed by medical wards intensive care unit (ICUs). Worldwide efforts sprouted coordinate proper response increasing surge capacity optimizing diagnosis containment. Within complex scenario of outbreak, community shared scientific research implemented best‐guess imaging strategies in order save time...
Background and Purpose: Prolonged mechanical ventilation can greatly increase morbidity mortality. Diaphragm weakness has been identified as a major contributor for 50% of patients; however, other muscles besides the diaphragm contribute to efficient ventilatory function. The purpose this study was compare change in deoxyhemoglobin (ΔHHb) muscle oxygen saturation (ΔSmO 2 ) (markers recruitment) 3 extra-diaphragmatic across 4 different bed exercises. Methods: Using pretest–posttest design,...