A5005815909- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Airway Management and Intubation Techniques
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Diabetes Management and Research
- Neonatal Respiratory Health Research
- Anesthesia and Pain Management
- Circadian rhythm and melatonin
- Ultrasound in Clinical Applications
- Genetics, Aging, and Longevity in Model Organisms
- Cardiac Health and Mental Health
- Adipose Tissue and Metabolism
- Cerebral Venous Sinus Thrombosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Sleep and Work-Related Fatigue
- Diverse Academic Research Analysis
- Vestibular and auditory disorders
- Mechanical Circulatory Support Devices
- Neurobiology and Insect Physiology Research
- Pharmaceutical Practices and Patient Outcomes
- Diabetes and associated disorders
- Meningioma and schwannoma management
- Emergency and Acute Care Studies
St. Michael's Hospital
2021-2025
University of Toronto
2010-2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2016-2024
Universidade de São Paulo
2022
Unity Health Toronto
2022
Chongqing Electromechanical Holdings (China)
2018
Committee on Publication Ethics
2018
Centro Hospitalar do Porto
2016
Hospices Civils de Lyon
2013
University of California, Davis
2012
Abstract Editor’s Perspective What We Already Know about This Topic Article Tells Us That Is New Background Intraoperative lung-protective ventilation has been recommended to reduce postoperative pulmonary complications after abdominal surgery. Although the protective role of a more physiologic tidal volume established, added protection afforded by positive end-expiratory pressure (PEEP) remains uncertain. The authors hypothesized that low fixed PEEP might not fit all patients and an...
In acute respiratory distress syndrome (ARDS), atelectatic solid-like lung tissue impairs transmission of negative swings in pleural pressure (Ppl) that result from diaphragmatic contraction. The localization more Ppl proportionally increases dependent stretch by drawing gas either other regions (e.g., nondependent [pendelluft]) or the ventilator. Lowering level spontaneous effort and/or converting to fluid-like might render noninjurious.To determine whether injury, and such injury would be...
Rationale: Hypoxemia during mechanical ventilation might be worsened by expiratory muscle activity, which reduces end-expiratory lung volume through collapse. A proposed mechanism of benefit from neuromuscular blockade (NMBA) in acute respiratory distress syndrome (ARDS) is abolition efforts. This may contribute to restoration volumes. The prevalence this phenomenon, however, unknown. Objectives: To investigate the incidence and amount impedance (EELI) increase after NMBA, clinical factors...
Insulin signaling plays a prominent role in regulation of dauer formation and longevity <i>Caenorhabditis elegans</i>. Here, we show that insulin also is required benzaldehyde–starvation associative plasticity, which worms pre-exposed to the odor attractant benzaldehyde absence food subsequently demonstrate conditioned aversion response toward odorant. Animals with mutations insulin-related 1 (<i>ins-1</i>), abnormal 2 (<i>daf-2</i>), aging alteration (<i>age-1</i>), encode homolog human...
High-flow nasal cannula generates positive airway pressure and reduces respiratory rate. Our findings confirm these physiological effects when the mouth is kept closed. An increased resistance to breathing induces a longer expiratory phase, which leads decreased rate minute ventilation, therefore workload, counterbalancing pressure-time product per liter. These are less apparent with open not observed continuous pressure.
Abstract Background Protective ventilation seems crucial during early Acute Respiratory Distress Syndrome (ARDS), but the optimal duration of lung protection remains undefined. High driving pressures (ΔP) and excessive patient ventilatory drive may hinder recovery, resulting in self-inflicted injury. The hidden nature ΔP generated by effort complicates situation further. Our study aimed to assess feasibility an extended strategy that includes a stepwise protocol control drive, assessing its...
The nematode Caenorhabditis elegans can adapt to both the AWC-sensed odorants benzaldehyde (Bnz) and isoamyl alcohol (IsoA) reciprocally cross-adapt. Yet we reveal that these four adaptation scenarios actually represent two distinct forms of learning: nonassociative habituation associative learning by pairing with a starvation unconditioned stimulus. Training single odorant IsoA leads memory traces, which be preferentially accessed either Bnz or retrieval stimulus, respectively. This...
Velázquez, Ahida MD, MSc; Pereira, Sérgio M. PhD; Rigamonti, Andrea MD; Giammarioli, Benedetta Liu, Melissa Ma, Kan MD Author Information
The mechanisms whereby prolonged plasma free fatty acids elevation, as found in obesity, causes hepatic insulin resistance are not fully clarified. We herein investigated whether inhibition of p38 mitogen-activated protein kinase (MAPK) prevented following lipid infusion. Chronically cannulated rats were subdivided into one four intravenous (i.v.) treatments that lasted 48 h: Saline (5.5 μl min(-1)), Intralipid plus heparin (IH, 20% Intralipid+20 U ml(-1) heparin; 5.5 IH+p38 MAPK inhibitor...
Abstract Data on predictors of intraoperative cardiac arrest (ICA) outcomes are scarce in the literature. This study analysed poor outcome and their prognostic value after an ICA. Clinical laboratory data before 24 hours (h) ICA were as for no return spontaneous circulation (ROSC) h 1-year mortality. Receiver operating characteristic curves each predictor sensitivity, specificity, positive negative likelihood ratios, post-test probability calculated. A total 167,574 anaesthetic procedures...
Background Strong spontaneous inspiratory efforts can be difficult to control and prohibit protective mechanical ventilation. Instead of using deep sedation neuromuscular blockade, the authors hypothesized that perineural administration lidocaine around phrenic nerve would reduce tidal volume (VT) peak transpulmonary pressure in spontaneously breathing patients with acute respiratory distress syndrome. Methods An established animal model syndrome six female pigs was used a proof-of-concept...
Information about respiratory mechanics such as resistance, elastance, and muscular pressure is important to mitigate ventilator-induced lung injury. Particularly during support ventilation, the available options quantify breathing effort calculate system are often invasive or complex. We herein propose a robust flexible estimation of better than current methods. developed method for non-invasively estimating using only flow signals. Mixed-integer quadratic programming (MIQP) was employed,...