A5040826667- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Electrical and Bioimpedance Tomography
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Airway Management and Intubation Techniques
- Non-Invasive Vital Sign Monitoring
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- Pleural and Pulmonary Diseases
- Thermal Regulation in Medicine
- Restraint-Related Deaths
- Ultrasound in Clinical Applications
- Cardiovascular Disease and Adiposity
- Mechanical Circulatory Support Devices
- Animal Nutrition and Physiology
- Obstructive Sleep Apnea Research
- Effects of Environmental Stressors on Livestock
- Cardiac, Anesthesia and Surgical Outcomes
- Transplantation: Methods and Outcomes
- Anesthesia and Pain Management
- Histone Deacetylase Inhibitors Research
- Pharmacological Effects and Assays
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2020-2025
Massachusetts General Hospital
2024-2025
Harvard University
2024-2025
American Thoracic Society
2024
Centro Universitário das Faculdades Metropolitanas Unidas
2024
Universidade de São Paulo
2020-2023
Timpel (Brazil)
2021-2023
Hagerstown Community College
2023
Hospital do Coração
2022
General University Hospital in Prague
2021
Defining lung recruitability is needed for safe positive end-expiratory pressure (PEEP) selection in mechanically ventilated patients. However, there no simple bedside method including both assessment of and risks overdistension as well personalized PEEP titration.
Rationale: Hypoxemia during mechanical ventilation might be worsened by expiratory muscle activity, which reduces end-expiratory lung volume through collapse. A proposed mechanism of benefit from neuromuscular blockade (NMBA) in acute respiratory distress syndrome (ARDS) is abolition efforts. This may contribute to restoration volumes. The prevalence this phenomenon, however, unknown. Objectives: To investigate the incidence and amount impedance (EELI) increase after NMBA, clinical factors...
Abstract Rationale Patients with coronavirus disease-19-related acute respiratory distress syndrome (C-ARDS) could have a specific physiological phenotype as compared those affected by ARDS from other causes (NC-ARDS). Objectives To describe the effect of positive end-expiratory pressure (PEEP) on mechanics in C-ARDS patients supine and prone position, to NC-ARDS. The primary endpoint was best PEEP defined smallest sum hyperdistension collapse. Methods Seventeen moderate-to-severe were...
Abstract Background A sequential change in body position from supine-to-both lateral positions under constant ventilatory settings could be used as a postural recruitment maneuver case of acute respiratory distress syndrome (ARDS), provided that sufficient positive end-expiratory pressure (PEEP) prevents derecruitment. This study aims to evaluate the feasibility and physiological effects early mechanically ventilated COVID-19 ARDS patients. Methods cohort 15 patients receiving...
Abstract Introduction Electrical impedance tomography (EIT) can be used to assess ventilation/perfusion ( V / Q ) mismatch within the lungs. Several methods have been proposed, some of them neglecting absolute value alveolar ventilation A and cardiac output C ). Whether this omission results in acceptable bias is unknown. Methods Pixel-level maps 25 ARDS patients were computed once considering (absolute map) (relative . Previously published indices using relative maps. Indices with compared...
Abstract Background Protective ventilation seems crucial during early Acute Respiratory Distress Syndrome (ARDS), but the optimal duration of lung protection remains undefined. High driving pressures (ΔP) and excessive patient ventilatory drive may hinder recovery, resulting in self-inflicted injury. The hidden nature ΔP generated by effort complicates situation further. Our study aimed to assess feasibility an extended strategy that includes a stepwise protocol control drive, assessing its...
Background: After the improvement of initial phase ARDS, when patients begin spontaneous breathing and weaning from mechanical ventilation, some may present abnormal patterns, whose evaluation repercussions were poorly studied. This study proposed to evaluate patterns through use electrical impedance tomography (EIT), clinical, respiratory mechanics, ventilatory parameters according types ventilation. Methods: was a prospective cohort subjects with ARDS who considered able be weaned...
"Assessment of Pulmonary Perfusion in a Pediatric Patient with Acute Hypoxic Respiratory Failure Using Electrical Impedance Tomography." American Journal and Critical Care Medicine, 0(ja), pp.
Abstract Background Among the challenges for personalizing management of mechanically ventilated patients with coronavirus disease (COVID-19)-associated acute respiratory distress syndrome (ARDS) are effects different positive end-expiratory pressure (PEEP) levels and body positions in regional lung mechanics. Right-left aeration asymmetry poorly recruitable lungs increased recruitability alternating position between supine prone have been reported. However, real-time changing PEEP on...
Lower fractional inspired oxygen tension (Fio2) during general anesthesia can reduce lung atelectasis. The objectives are to evaluate the effect of two Fio2 (0.4 and 1) low positive end-expiratory pressure (PEEP) ventilation over perfusion distribution, volume, regional ventilation. These variables were evaluated at PEEP levels unilateral
Introduction General anesthesia is associated with the development of atelectasis, which may affect lung ventilation. Electrical impedance tomography (EIT) a noninvasive imaging tool that allows monitoring in real time topographical changes aeration and Objective To evaluate pattern distribution pulmonary ventilation through EIT before after induction pediatric patients without disease undergoing nonthoracic surgery. Methods This was prospective observational study including healthy children...
Low-volume lung injury encompasses local concentration of stresses in the vicinity collapsed regions heterogeneously ventilated lungs. We aimed to study effects on ventilation and perfusion distributions a sequential lateral positioning (30°) strategy using electrical impedance tomography imaging porcine experimental model early acute respiratory distress syndrome (ARDS). hypothesized that such strategy, including real-time individualization positive end-expiratory pressure (PEEP) whenever...
OBJECTIVES: Experimental models suggest that prone position and positive end-expiratory pressure (PEEP) homogenize ventral–dorsal ventilation distribution regional respiratory compliance. However, this response still needs confirmation on humans. Therefore, study aimed to assess the changes in global mechanics supine positions over a range of PEEP levels acute distress syndrome (ARDS) patients. DESIGN: A prospective cohort study. PATIENTS: Twenty-two intubated patients with ARDS caused by...
Abstract Introduction Electrical impedance tomography (EIT) is a noninvasive, radiation-free, bedside tool to monitor ventilation distribution in real time. Objective To evaluate, pediatric COVID-19 patients, the using EIT and compare it thoracic computed (TCT) or chest radiograph results obtained these patients. Methods This was prospective, observational clinical study including patients admitted intensive care unit of private hospital. The monitored with tested positive for were submitted...
To evaluate the effects of four flow rates on functional residual capacity (FRC) and pulmonary ventilation distribution while using a high-flow nasal cannula (HFNC).Our hypothesis is that below 1.5 L·kg-1 ·min-1 lead to FRC loss respiratory distress.A single-center, prospective clinical study.Infants diagnosed with acute viral bronchiolitis were given HFNC.Through study, different rates, 2.0, 1.5, 1.0, 0.5 , pattern evaluated electrical impedance tomography. The variation (delta Z),...
Abstract Real-time effects of changing body position and positive end-expiratory pressure (PEEP) on regional lung overdistension collapse in individual patients remain largely unknown not timely monitored. The aim this study was to individualize PEEP supine prone positions seeking reduce mechanically ventilated with coronavirus disease (COVID-19)-induced acute respiratory distress syndrome (ARDS). We hypothesized that positioning bedside titrated would provide attenuation both collapse. In...