A5065042242- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neurobiology of Language and Bilingualism
- Memory and Neural Mechanisms
- EEG and Brain-Computer Interfaces
- Genetics and Neurodevelopmental Disorders
- Fetal and Pediatric Neurological Disorders
- Glioma Diagnosis and Treatment
- Neurological disorders and treatments
- Neonatal and fetal brain pathology
- Retinal Development and Disorders
- Advanced MRI Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Diet and metabolism studies
- Meningioma and schwannoma management
- Smoking Behavior and Cessation
- Developmental Biology and Gene Regulation
- Ocular Disorders and Treatments
- Behavioral Health and Interventions
- Glycogen Storage Diseases and Myoclonus
- Health Sciences Research and Education
- Memory Processes and Influences
University College London
2016-2025
National Hospital for Neurology and Neurosurgery
2016-2025
Epilepsy Society
2015-2024
Royal London Hospital
2024
Queen's University
2020-2023
The University of Western Australia
2023
Newcastle University
2023
University of Nottingham
2023
Victor (Japan)
2023
University of Pennsylvania
2020-2022
See Bernasconi (doi:10.1093/aww202) for a scientific commentary on this article. Temporal lobe epilepsy, the most prevalent form of chronic focal is associated with high prevalence cognitive impairment but responsible underlying pathological mechanisms are unknown. Tau, microtubule-associated protein, hallmark several neurodegenerative diseases including Alzheimer's disease and traumatic encephalopathy. We hypothesized that hyperphosphorylated tau pathology decline in temporal epilepsy...
A large-scale virtual reality town was used to test the topographical and episodic memory of patients with unilateral temporal lobe damage. Seventeen right 13 left lobectomy were compared 16 healthy matched control subjects. After they had explored town, subjects' tested by requiring them navigate specific locations in town. The ability recognize scenes from draw maps also assessed. Following tests, subjects followed a route around same but now collected objects two different characters...
<h3>OBJECTIVE</h3> To explore the impact of topiramate on tests intellect and other cognitive processes. <h3>METHODS</h3> This was a retrospective study. The neuropsychological test scores 18 patients obtained before after introduction treatment with (median dose 300 mg) were compared changes in performance who had undergone repeat assessments at same time intervals. Complaints decline precipitated referral for reassessment five cases treated group. groups matched age intellectual level...
Recurrent episodes with interictal affective aggression are a rare but well-recognized problem in patients temporal lobe epilepsy. They referred to as episodic dyscontrol or, more precisely, intermittent explosive disorder (IED). The amygdala play crucial role the evaluation of multimodal sensory input and neurobiological mediation aggressive behaviour. With hippocampal sclerosis, context mesial being most common cause epilepsy, we hypothesized that might be affected by same pathogenic...
Summary: Purpose: To explore the relation between seizure‐related variables and cognitive change in patients with severe intractable epilepsy. Methods: A retrospective analysis of data from 136 who had undergone a assessment on two occasions at an interval ≥10 years. Cognitive measures included tests memory executive skills addition to intelligence quotients (IQ). Details were available regarding seizure type frequency intertest interval. Results: decline was occurred across wide range...
Abstract Heterozygous, de novo, loss‐of‐function mutations in SOX2 have been shown to cause bilateral anophthalmia. Here we provide a detailed description of the clinical features associated with five individuals reported and four newly identified cases (including first missense mutation). The ‐associated ocular malformations are variable type, but most often severe. Of nine patients, six had anophthalmia two contralateral microphthalmia sclerocornea. remaining case microphthalmia, posterior...
While some patients experience a decline in memory function following an anterior temporal lobe resection, there is considerable individual variation the extent, nature, and direction of postoperative change. Patients with surgically remediable epilepsy differ etiology, extent type underlying pathology, on demographic epilepsy-related variables, all which may have impact their pre- neuropsychological functioning. This study examined relationship between these variables decline.Logistic...
<h3>Objective:</h3> The aim of this study was to determine if there were focal cortical abnormalities in juvenile myoclonic epilepsy (JME) using neuropsychological investigations and MRI. <h3>Methods:</h3> Twenty-eight patients with JME a large sample healthy controls assessed series tests as well structural diffusion tensor MRI (DTI). DTI measures fractional anisotropy (FA) within white matter skeleton. <h3>Results:</h3> Neuropsychological testing indicated subtle dysfunctions verbal...
Summary Purpose: Anterior temporal lobe resection (ATLR) controls seizures in up to 70% of patients with intractable epilepsy (TLE) but, the language dominant hemisphere, may impair function, particularly naming. Functional reorganization can occur within ipsilateral and contralateral hemispheres. We investigated left‐hemisphere–dominant before after ATLR; whether preoperative functional magnetic resonance imaging (fMRI) predicts postoperative naming decline; efficiency networks. Methods:...
Functional magnetic resonance imaging has demonstrated reorganization of memory encoding networks within the temporal lobe in epilepsy, but little is known extra-temporal these patients. We investigated and refractory epilepsy neural correlates successful subsequent formation. studied 44 patients with unilateral hippocampal sclerosis (24 left) 26 healthy control subjects. All participants performed a functional paradigm faces words out-of-scanner recognition assessments. A blocked analysis...
<h3>Background:</h3> Anterior temporal lobe resection (ATLR) benefits many patients with refractory epilepsy (TLE) but may be complicated by material specific memory impairments, typically of verbal following left ATLR, and non-verbal right ATLR. Preoperative functional MRI (fMRI) help in the prediction these deficits. <h3>Objective:</h3> To assess value preoperative fMRI deficits both left- right-sided <h3>Methods:</h3> We report 15 unilateral TLE undergoing ATLR; eight underwent dominant...
Summary Purpose: Neurosurgery is an effective therapy for selected individuals with medically refractory temporal lobe epilepsy (TLE). De novo psychopathology may complicate the postsurgical outcome. Our aims were to identify predictors of de psychiatric and seizure outcome following TLE surgery. Methods: Medical records 280 patients who underwent surgery reviewed. Preoperative postoperative diagnoses identified, in addition information on recurrence neuropsychological status. Logistic...
<h3>Importance</h3> A functional area associated with the piriform cortex, termed<i>area tempestas</i>, has been implicated in animal studies as having a crucial role modulating seizures, but similar evidence is limited humans. <h3>Objective</h3> To assess whether removal of cortex postoperative seizure freedom patients temporal lobe epilepsy (TLE) proof-of-concept for relevance this human TLE. <h3>Design, Setting, and Participants</h3> This cohort study used voxel-based morphometry...
<h3>Objective:</h3> To develop a clinically applicable memory functional MRI (fMRI) method of predicting postsurgical outcome in individual patients. <h3>Methods:</h3> In this prospective cohort study, 50 patients with temporal lobe epilepsy (23 left) and 26 controls underwent an fMRI encoding paradigm words subsequent out-of-scanner recognition assessment. Neuropsychological assessment was performed preoperatively 4 months after anterior resection, at equal time intervals controls. An...
Impairment of naming function is a critical problem for temporal lobe epilepsy patients, yet the neural correlates disruption language networks are poorly understood. Using functional MRI, we investigated activation and task-related connectivity left their relation to clinical performance disease characteristics. We studied 59 adult patients with (35 epilepsy) 32 healthy controls auditory visual MRI tasks. Time series maxima in posterior inferior were extracted create psychophysiological...
Cognitive impairment is a common comorbidity of epilepsy and adversely impacts people with both frontal lobe (FLE) temporal (TLE) epilepsy. While its neural substrates have been investigated extensively in TLE, functional imaging studies FLE are scarce. In this study, we profiled the processes underlying cognitive directly compared TLE to establish commonalities differences. We 172 adult participants (56 FLE, 64 52 controls) using neuropsychological tests four MRI tasks probing expressive...
Psychosis of epilepsy (POE) has been recognized as a severe complication chronic intractable for more than century. Most the clinical symptoms POE are reminiscent schizophrenia. Nevertheless, there is general agreement that phenomenology differs from classical The temporal lobe hypothesis schizophrenia put forward in 1960s notes episodes with paranoid psychoses prevalent (TLE). However, aetiology and pathogenesis poorly understood. One strongest biological findings volume loss structures...
Summary: Purpose: Quantitative MRI techniques provide an unparalleled opportunity to examine in vivo the relationship between extent and laterality of hippocampal pathology associated neuropsychological deficits. The purpose this study was nature quantitative measures measures, using a multivariate approach. Methods: We examined two structure; volumes (HCvol) T2 relaxation times (HCT2), memory performance, 80 presurgical temporal lobe epilepsy patients. Results: As group, patients with left...