Elizabeth Levitis
A5058538702- Genetics and Neurodevelopmental Disorders
- Alzheimer's disease research and treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Dementia and Cognitive Impairment Research
- Conferences and Exhibitions Management
- Advanced Neuroimaging Techniques and Applications
- Stress Responses and Cortisol
- Genomic variations and chromosomal abnormalities
- Neural dynamics and brain function
- Congenital heart defects research
- Neuroendocrine regulation and behavior
- Biomedical and Engineering Education
- Child and Adolescent Psychosocial and Emotional Development
- Radiomics and Machine Learning in Medical Imaging
- Health, Environment, Cognitive Aging
- Autism Spectrum Disorder Research
- Brain Tumor Detection and Classification
- Sexual Differentiation and Disorders
- AI in cancer detection
- COVID-19 epidemiological studies
- Genetic Associations and Epidemiology
- Functional Brain Connectivity Studies
- Psychosomatic Disorders and Their Treatments
- Digital Marketing and Social Media
- Mental Health Research Topics
National Institute of Mental Health
2021-2024
University College London
2021-2024
National Institutes of Health
2024
National Institute of Mental Health
2024
Wellcome Centre for Integrative Neuroimaging
2024
University of Oxford
2024
Radboud University Nijmegen
2024
University of Toronto
2024
Montreal Neurological Institute and Hospital
2020-2022
McGill University
2020-2022
Tau is a hallmark pathology of Alzheimer's disease, and animal models have suggested that tau spreads from cell to through neuronal connections, facilitated by β-amyloid (Aβ). We test this hypothesis in humans using an epidemic spreading model (ESM) simulate spread, compare these simulations observed patterns measured tau-PET 312 individuals along disease continuum. Up 70% the variance overall spatial pattern can be explained our model. Surprisingly, ESM predicts irrespective whether brain...
Abstract As the global health crisis unfolded, many academic conferences moved online in 2020. This move has been hailed as a positive step towards inclusivity its attenuation of economic, physical, and legal barriers effectively enabled individuals from groups that have traditionally underrepresented to join participate. A number studies outlined how moving made it possible gather more community increased opportunities for with various constraints, e.g., caregiving responsibilities. Yet,...
In vivo neuroimaging studies have established several reproducible volumetric sex differences in the human brain, but causes of such are hard to parse. While mouse models useful for understanding cellular and mechanistic bases sex-specific brain development, there been no attempts formally compare neuroanatomical ascertain how well they translate. Addressing this question would shed critical light on use as a translational model provide insights into degree which volume conserved across...
In vivo neuroimaging studies have established several reproducible volumetric sex differences in the human brain, but causes of such are hard to parse. While mouse models useful for understanding cellular and mechanistic bases sex-specific brain development, there been no attempts formally compare neuroanatomical ascertain how well they translate. Addressing this question would shed critical light on use as a translational model provide insights into degree which volume conserved across...
All eutherian mammals show chromosomal sex determination with contrasting chromosome dosages (SCDs) between males (XY) and females (XX). Studies in transgenic mice humans trisomy (SCT) have revealed direct SCD effects on regional mammalian brain anatomy, but we lack a formal test for cross-species conservation of these effects. Here, develop harmonized framework comparative structural neuroimaging apply this to systematically profile anatomy both by groups SCT (XXY XYY) versus XY controls....
Amyloid-beta deposition is one of the hallmark pathologies in both sporadic Alzheimer's disease and autosomal-dominant disease, latter which caused by mutations genes involved amyloid-beta processing. Despite being a centrepiece to some differences between these subtypes have been observed with respect spatial pattern amyloid-beta. Previous work has shown that individuals spanning spectrum can be reproduced high accuracy using an epidemic spreading model simulates diffusion across neuronal...
Diverse gene dosage disorders (GDDs) increase risk for psychiatric impairment, but characterization of GDD effects on the human brain has so far been piecemeal, with few simultaneous analyses multiple features across different GDDs.
Abstract In vivo neuroimaging studies have established several reproducible volumetric sex differences in the human brain, but causes of such are hard to parse. While mouse models useful for understanding cellular and mechanistic bases sex-biased brain development mammals, there been no attempts formally compare across whole ascertain how well they translate. Addressing this question would shed critical light on use as a translational model provide insights into degree which volume conserved...
Brainhack is an innovative meeting format that promotes scientific collaboration and education in open inclusive environment. Departing from the formats of typical workshops, these events are based on grassroots projects training, foster reproducible practices. We describe here multifaceted, lasting benefits Brainhacks for individual participants, particularly early career researchers. further highlight unique contributions can make to research community, contributing progress by...
As the global health crisis unfolded throughout world, many academic conferences moved online in 2020. This move has been hailed as a positive step towards inclusivity its attenuation of economic, physical and legal barriers effectively enabled individuals who have traditionally underrepresented to join participate. A number studies outlined how moving made it possible gather more community increased opportunities for with various constraints, e.g. caregiving responsibilities. Yet, mere...
In vivo neuroimaging studies have established several reproducible volumetric sex differences in the human brain, but causes of such are hard to parse. While mouse models useful for understanding cellular and mechanistic bases sex-biased brain development mammals, there been no attempts formally compare across whole ascertain how well they translate. Addressing this question would shed critical light on use as a translational model provide insights into degree which volume conserved mammals....
Combining neuroimaging datasets from multiple sites and scanners can help increase statistical power thus provide greater insight into subtle neuroanatomical effects. However, site-specific effects pose a challenge by potentially obscuring the biological signal introducing unwanted variance. Existing harmonization techniques, which use models to remove such effects, have been shown incompletely site while also failing preserve variability. More recently, generative using GANs or...
Background: Evidence suggests a non-specific mapping between psychiatric disorders and underlying neurobiological substrates. A dimensional psychopathology framework may prove useful for organizing observed alterations along broad psychopathological dimensions. Methods: We applied latent class analysis to identify clinical cohorts of symptomatic homogeneity represent the end specific dimensions (i.e., internalizing/externalizing, p-factor), using baseline data (N = 11860) from Adolescent...
Summary All eutherian mammals show chromosomal sex determination with contrasting chromosome dosages (SCDs) between males (XY) and females (XX). Studies in transgenic mice humans trisomy (SCT) have revealed direct SCD effects on regional mammalian brain anatomy, but we lack a formal test for cross-species conservation of these effects. Here, develop harmonized framework comparative structural neuroimaging apply this to systematically profile anatomy both by groups SCT (XXY XYY) vs. XY...
Diverse gene dosage disorders (GDDs) increase risk for psychiatric impairment, but characterization of GDD effects on the human brain has so far been piecemeal and lacked simultaneous analysis multiple features across different GDDs. Here, through multimodal neuroimaging 3 aneuploidy syndromes (XXY, XYY, trisomy 21), we reveal considerable diversity in cortical changes GDDs imaging-derived phenotypes (IDPs). This variegation IDP change underlines limitations studying unimodally. Integration...
Abstract Amyloid-beta (Aβ) deposition is one of the hallmark pathologies in both sporadic Alzheimer’s disease (sAD) and autosomal dominant (ADAD), latter which caused by mutations genes involved Aβ processing. Despite being a centerpiece to sAD ADAD, some differences between these AD subtypes have been observed with respect spatial pattern Aβ. Previous work has shown that individuals spanning spectrum can be reproduced high accuracy using an epidemic spreading model (ESM), simulates...