A5009541673- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Epilepsy research and treatment
- Blind Source Separation Techniques
- Functional Brain Connectivity Studies
- Heart Rate Variability and Autonomic Control
- Memory and Neural Mechanisms
- Intensive Care Unit Cognitive Disorders
- Music Therapy and Health
- Photoreceptor and optogenetics research
- Muscle activation and electromyography studies
- Advanced Sensor and Energy Harvesting Materials
- Health and Lifestyle Studies
- Child and Adolescent Psychosocial and Emotional Development
- Visual perception and processing mechanisms
- Transcranial Magnetic Stimulation Studies
- Infant Health and Development
- Finance, Taxation, and Governance
- Infant Development and Preterm Care
- Gaze Tracking and Assistive Technology
- Mindfulness and Compassion Interventions
- Pediatric Pain Management Techniques
Universidad de Los Andes
2016-2025
Universidad de Los Andes
2016-2018
National Training Service
2017
Fundación Universitaria Konrad Lorenz
2017
Institut du Cerveau
2010-2014
Inserm
2010-2012
Pitié-Salpêtrière Hospital
2010-2012
Sorbonne Université
2010-2012
Centre National de la Recherche Scientifique
2010-2012
University of Chile
2004-2011
Neuronal activity differs between wakefulness and sleep states. In contrast, an attractor state, called self-organized critical (SOC), was proposed to govern brain dynamics because it allows for optimal information coding. But is the human SOC each vigilance state despite variations in neuronal dynamics? We characterized avalanches – spatiotemporal waves of enhanced - from dense intracranial depth recordings humans. showed that avalanche distributions closely follow a power law hallmark...
Gamma oscillations (40-120 Hz), usually associated with waking functions, can be recorded in the deepest stages of sleep animals. The full details their large-scale coordination across multiple cortical networks are still unknown. Furthermore, it is not known whether similar characteristics also present human brain. In this study, we examined existence gamma during polysomnographically defined sleep-wake states using microelectrode recordings (up to 56 channels), single-cell and spike-time...
Summary From the very beginning seizure prediction community faced problems concerning evaluation, standardization, and reproducibility of its studies. One main reasons for these shortcomings was lack access to high‐quality long‐term electroencephalography (EEG) data. In this article we present EPILEPSIAE database, which made publicly available in 2012. We illustrate content scope. The database provides EEG recordings 275 patients as well extensive metadata standardized annotation data sets....
High Frequency Oscillations (HFOs) in the brain have been associated with different physiological and pathological processes. In epilepsy, HFOs might reflect a mechanism of epileptic phenomena, serving as biomarker epileptogenesis epileptogenicity. Despite valuable information provided by HFOs, their correct identification is challenging task. A comprehensive application, RIPPLELAB, was developed to facilitate analysis HFOs. RIPPLELAB provides wide range tools for manual automatic detection...
Abstract Seizure detection is a routine process in epilepsy units requiring manual intervention of well-trained specialists. This could be extensive, inefficient and time-consuming, especially for long term recordings. We proposed an automatic method to detect epileptic seizures using imaged-EEG representation brain signals. To accomplish this, we analyzed EEG signals from two different datasets: the CHB-MIT Scalp database EPILEPSIAE project that includes scalp intracranial used fully...
Neocortical local field potentials have shown that gamma oscillations occur spontaneously during slow-wave sleep (SWS). At the macroscopic EEG level in human brain, no evidences were reported so far. In this study, by using simultaneous scalp and intracranial recordings 20 epileptic subjects, we examined cerebral cortex SWS. We report low (30–50 Hz) high (60–120 frequency bands recurrently emerged all investigated regions their amplitudes coincided with specific phases of cortical slow wave....
Abstract Recent evidence suggests that some seizures are preceded by preictal changes start from minutes to hours before an ictal event. Nevertheless adequate statistical evaluation in a large database of continuous multiday recordings is still missing. Here, we investigated the existence long-term intracranial 53 patients with intractable partial epilepsy (in total 531 days and 558 clinical seizures). We describe measure brain excitability based on slow modulation high-frequency gamma...
Closed-loop auditory stimulation (CLAS) is a method for enhancing slow oscillations (SOs) through the presentation of clicks during sleep. CLAS boosts SOs amplitude and sleep spindle power, but optimal timing click delivery remains unclear. Here, we determine time to present maximize enhancement SO likelihood.We examined main factors predicting spindles in dataset 21 young 17 older subjects. The participants received slow-wave-sleep two experimental conditions: sham stimulation....
Recent reports in human demonstrate a role of theta-gamma coupling memory for spatial episodes and lack people experiencing temporal lobe epilepsy, but the mechanisms are unknown. Using multisite silicon probe recordings epileptic rats engaged episodic-like object recognition tasks, we sought to evaluate absence epileptiform activities. Our data reveal specific association between (30-60 Hz) at proximal stratum radiatum CA1 deficits. We targeted microcircuit with novel approach identify...
La investigación tuvo como objetivo determinar la relación entre el Plan de Desarrollo Concertado y Calidad Vida los habitantes del Distrito Tamburco 2023. Destacando importancia plan en correlación calidad vida población, a partir constructos científicos. El estudio es una sustantiva, básica, tipo correlacional, con diseño no experimental, descriptivo-correlacional corte transversal, ya que datos se obtuvieron un solo momento, muestra probabilística 89 habitantes. Se diseñó instrumento...
Slow waves constitute the main signature of sleep in electroencephalogram (EEG). They reflect alternating periods neuronal hyperpolarization and depolarization cortical networks. While recent findings have demonstrated their functional role shaping strengthening networks, a large-scale characterization these two processes remains elusive human brain. In this study, by using simultaneous scalp EEG intracranial recordings 10 epileptic subjects, we examined dynamics over large extent cortex. We...
Burn patients often face elevated pain, anxiety, and depression levels. Music therapy adds to integrative care in burn patients, but research including electrophysiological measures is limited. This study reports signals analysis during Music-Assisted Relaxation (MAR) with the Intensive Care Unit (ICU). a sub-analysis of an ongoing trial music ICU. Electroencephalogram (EEG), electrocardiogram (ECG), electromyogram (EMG) were recorded MAR nine patients. Additionally, background pain levels...
Elevations in neuronal cholesterol have been associated with several degenerative diseases. An enhanced excitability and synchronous firing surviving neurons are among the sequels of death these diseases also some epileptic syndromes. Here, we attempted to increase levels, using a short hairpin RNA suppress expression enzyme cytochrome P450 family 46, subfamily A, polypeptide 1 gene (CYP46A1). This protein hydroxylates so facilitates transmembrane extrusion. A CYP46A1construction coupled...
Wearable in-ear electroencephalographic (EEG) devices hold significant promise for advancing brain monitoring technologies into everyday applications. However, despite the current availability of several EEG in market, there remains a critical need robust validation against established clinical-grade systems. In this study, we carried out detailed examination signal performance mobile device from Naox Technologies. Our investigation had two main goals: firstly, evaluating hardware circuit’s...
Pregnancy and puerperium are typified by marked biobehavioral changes. These changes, which traceable in both mothers fathers, play an important role parenthood may modulate social cognition abilities. However, the latter effects remain notably unexplored parents of newborns (PNs). To bridge this gap, we assessed empathy emotions (envy Schadenfreude) 55 PNs 60 controls (childless healthy participants without a romantic relationship or sexual intercourse previous 48 hours). We used facial...