A5000299771- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Neural dynamics and brain function
- Neuroscience of respiration and sleep
- Neuroendocrine regulation and behavior
- Circadian rhythm and melatonin
- Photoreceptor and optogenetics research
- EEG and Brain-Computer Interfaces
- Obstructive Sleep Apnea Research
- Cardiovascular and Diving-Related Complications
- Heart Rate Variability and Autonomic Control
- High Altitude and Hypoxia
- Receptor Mechanisms and Signaling
- Olfactory and Sensory Function Studies
- Stress Responses and Cortisol
- Epilepsy research and treatment
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Birth, Development, and Health
- Functional Brain Connectivity Studies
- Neonatal and fetal brain pathology
- Tryptophan and brain disorders
- Treatment of Major Depression
University of Alberta
2016-2025
Women and Children’s Health Research Institute
2016-2025
Prostate Cancer Research
2025
University College London
2025
Czech Academy of Sciences, Institute of Physiology
2012-2014
Institute of Psychology
2014
Institut des Sciences Cognitives Marc Jeannerod
2010-2012
Chicago Neuropsychology Group
2012
University of Wisconsin–Madison
2009
Fondazione IRCCS Istituto Neurologico Carlo Besta
2000-2003
Although the induction of behavioural unconsciousness during sleep and general anaesthesia has been shown to involve overlapping brain mechanisms, involves cyclic fluctuations between different states known as active (paradoxical or rapid eye movement: REM) quiet (slow-wave non-REM: nREM) stages whereas commonly used anaesthetics induce a unitary slow-wave state.Long-duration, multi-site forebrain field recordings were performed in urethane-anaesthetized rats. A spontaneous rhythmic...
Data from perinatal and juvenile rodents support our hypothesis that the preBötzinger complex generates inspiratory rhythm retrotrapezoid nucleus-parafacial respiratory group (RTN/pFRG) active expiration (AE). Although role of RTN/pFRG in adulthood is disputed, we hypothesized its rhythmogenicity persists but typically silenced by synaptic inhibition. We show adult anesthetized rats local pharmacological disinhibition or optogenetic excitation can generate AE transforms previously silent...
Various subsets of brain neurons express a hyperpolarization-activated inward current ( I h ) that has been shown to be instrumental in pacing oscillatory activity at both single-cell and network level. A characteristic feature the stellate cells (SCs) entorhinal cortex (EC) layer II, those giving rise main component perforant path input hippocampal formation, is their ability generate persistent, Na + -dependent rhythmic subthreshold membrane potential oscillations, which are thought...
State-dependent EEG in the hippocampus (HPC) has traditionally been divided into two activity patterns: theta, a large-amplitude, regular oscillation with bandwidth of 3-12 Hz, and large-amplitude irregular (LIA), less signal broadband characteristics. Both these patterns have linked to memory functions subserved by HPC. Here we describe, using extracellular field recording techniques naturally sleeping urethane-anesthetized rats, novel state present during deactivated stages sleep...
Gamma oscillations (40-120 Hz), usually associated with waking functions, can be recorded in the deepest stages of sleep animals. The full details their large-scale coordination across multiple cortical networks are still unknown. Furthermore, it is not known whether similar characteristics also present human brain. In this study, we examined existence gamma during polysomnographically defined sleep-wake states using microelectrode recordings (up to 56 channels), single-cell and spike-time...
Key points The ventilatory response to reduced oxygen (hypoxia) is biphasic, comprising an initial increase in ventilation followed by a secondary depression. Our findings indicate that, during hypoxia, astrocytes the pre‐Bötzinger complex (preBötC), critical site of inspiratory rhythm generation, release gliotransmitter that acts via P2Y 1 receptors stimulate and reduce In vitro analyses reveal ATP excitation preBötC involves receptor‐mediated Ca 2+ from intracellular stores. By identifying...
Abstract Navigating social environments is a fundamental challenge for the brain. It has been established that brain solves this problem, in part, by representing information an agent-centric manner; knowledge about others’ abilities or attitudes tagged to individuals such as ‘oneself’ ‘other’ 1–6 . This intuitive approach informed understanding of key nodes parts brain, dorsomedial prefrontal cortex (dmPFC) and anterior cingulate (ACC) 7–9 However, patterns combinations which might interact...
A multicompartmental biophysical model of entorhinal cortex layer II stellate cells was developed to analyze the ionic basis physiological properties, such as subthreshold membrane potential oscillations, action clustering, and medium afterhyperpolarization. In particular, simulation illustrates interaction persistent sodium current (I(Nap)) hyperpolarization activated inward (Ih) in generation oscillations. The role Ih contributing (mAHP) rebound spiking studied. slow calcium-activated...
Oscillation and synchronization of neural activity is important in normal brain function but also relevant to epileptogenesis. One the most frequent forms epilepsy originates temporal lobe circuitry which entorhinal cortex (EC) crucial. Because muscarinic receptor activation promotes oscillatory dynamics EC neurons, we investigated a slice preparation effects carbachol (CCh) on population EC. We found that CCh produced epileptiform EC, according field profile current source density analysis...
Brain state alternations resembling those of sleep spontaneously occur in rats under urethane anesthesia and they are closely linked with sleep-like respiratory changes. Although a common model for both physiology, we sought to determine if similar brain changes mice urethane. We made local field potential recordings from the hippocampus measured activity by means EMG intercostal, genioglossus, abdominal muscles. Similar results adult rats, anesthetized displayed quasi-periodic spontaneous...
Neuronal population oscillations at a variety of frequencies can be readily seen in electroencephalographic (EEG) as well local field potential recordings many different species. Although these brain rhythms have been studied for years, the methods identifying discrete oscillatory epochs are still widely variable across studies. The "better oscillation detection" (BOSC) method applies standardized criteria to detect runs "true" activity and rejects transient events that do not reflect actual...
Respiratory activity is most fragile during sleep, in particular paradoxical [or rapid eye movement (REM)] sleep and state transitions. Rats are commonly used to study respiratory neuromodulation, but rodent characterized by a highly fragmented pattern, thus making it very challenging examine different states potential pharmacological manipulations within them. Sleep-like brain-state alternations occur rats under urethane anesthesia may be an effective efficient model for itself. The present...
Abstract Sleep is a period of profound neural synchrony throughout the brain, phenomenon involved in various physiological functions. The coordination between neocortex and hippocampus, particular, appears to be critical for episodic memory, and, indeed, enhanced this circuit hallmark slow-wave sleep. However, it unclear how mediated. To end, we examined role thalamic nucleus reuniens (RE), midline body with reciprocal connections both prefrontal hippocampal cortices. Using combination...
1. Single-unit discharge patterns of cells in specific nuclei the caudal diencephalon were characterized relation to simultaneously recorded field activity from stratum moleculare dentate gyrus according criteria that have been used previously classify hippocampal formation (including entorhinal cortex), medial septum, and cingulate cortex. Theta (theta)-related classified as 1) tonic theta-ON, if they discharged nonrhythmically increased their rates during theta relative large, irregular...
Early in their formation, memories are thought to be labile, requiring a process called consolidation give them near-permanent stability. Evidence for as an active and biologically separate mnemonic has been established through posttraining manipulations of the brain that promote or disrupt subsequent retrieval. Consolidation is ultimately mediated via protein synthesis since translational inhibitors such anisomycin memory when administered critical time window just following initial...
Introduction The periaqueductal gray (PAG) has been previously established to play a key role in producing the vital changes respiration occurring response threat. However, it is not fully understood how PAG activation alters ongoing respiratory output, nor which pathways mediate these effects, as several regions have identified influence activity. Methods We used optogenetic tools conjunction with EMG recordings of inspiratory and expiratory musculature determine on short (250 ms) longer...
Fast (γ) oscillations in the cortex underlie rapid temporal coordination of large-scale neuronal assemblies processing sensory stimuli. Cortical γ rhythm is modulated vivo by cholinergic innervation from basal forebrain and can be generated vitro after exogenous stimulation. Using isolated guinea pig brain, an preparation that allows for study intact cerebrum, we studied spatial features activity evoked cholinomimetic carbachol (CCh) medial entorhinal (mEC). induced either arterial perfusion...
Abstract Single‐unit discharge patterns of entorhinal cortex (EC) cells were characterized in relation to simultaneously recorded hippocampal (HPC) field activity according criteria used previously classify the formation, medial septum, cingulate cortex, and caudal diencephalon. EC related HPC theta classified as (1) phasic theta‐on, if they discharged rhythmically, phase, with ongoing theta, but nonrhythmically during large, irregular (LIA); (2) tonic increased their rates relative LIA; (3)...