A5052193947- Multiple Sclerosis Research Studies
- SARS-CoV-2 and COVID-19 Research
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Long-Term Effects of COVID-19
- Chronic Lymphocytic Leukemia Research
- Retinal and Optic Conditions
- Peptidase Inhibition and Analysis
- COVID-19 Clinical Research Studies
- Parkinson's Disease and Spinal Disorders
- Sinusitis and nasal conditions
- Bacterial Infections and Vaccines
- Infectious Diseases and Tuberculosis
- Restless Legs Syndrome Research
- Antenna Design and Analysis
- Renin-Angiotensin System Studies
- Herpesvirus Infections and Treatments
- IgG4-Related and Inflammatory Diseases
- Connective Tissue Growth Factor Research
- Salivary Gland Disorders and Functions
- Full-Duplex Wireless Communications
- Neurosurgical Procedures and Complications
- Renal and related cancers
Institut Pierre Louis d‘Épidémiologie et de Santé Publique
2019-2025
Inserm
2021-2025
Assistance Publique – Hôpitaux de Paris
2015-2025
Sorbonne Université
2016-2025
Institut du Cerveau
2021-2025
Pitié-Salpêtrière Hospital
2016-2024
Centre National de la Recherche Scientifique
2023-2024
Université de Montpellier
2023
Centre Hospitalier Universitaire de Montpellier
2023
Hôpital Saint-Antoine
2020-2021
Importance In patients with multiple sclerosis (MS), factors associated severe COVID-19 include anti-CD20 therapies and neurologic disability, but it is still unclear whether these 2 variables are independently or the association depends on MS clinical course. Objective To assess between severity in relapsing-remitting (RRMS) progressive (PMS). Design, Setting, Participants This multicenter, retrospective cohort study used data from COVISEP study, which included February 1, 2020, to June 30,...
Epidemiological data reveal that 45% of persons with multiple sclerosis (PwMS) in France are more than 50 years. This population is susceptible to cancer, and this risk may be increased by frequent use immunosuppressive drugs. Consequently, concerns have arisen about the potential cancer PwMS how patients should screened managed terms risk. To develop evidence-based recommendations manage coexistence (MS). The French Group for Recommendations MS collected articles from PubMed university...
After observing increased sudden death risk associated with domperidone use, the European Medicines Agency (EMA) imposed usage restrictions in 2014, limiting age (≤60 years), daily dose (≤30 mg/day), and duration (≤7 days). Nausea commonly occurs as an adverse effect of dopaminergic drugs Parkinson's disease (PD) patients, few alternative anti-emetic options. This study aimed to assess prescription patterns French PD patients. In this multicenter study, all consecutive patients from...
Despite surgery, radiotherapy (RT) and temozolomide (TMZ), the prognosis of glioblastoma (GBM) patients remains dismal. Normally prescribed with aim to lower blood pressure, angiotensin-II (Ang-II) inhibitors were reported reduce angiogenesis tumour growth in several models including one glioma. Thus whether treatment Ang-II could be associated a better clinical outcome GBM was investigated.A series 81 consecutive patients, homogeneously treated RT TMZ for newly diagnosed, supratentorial...
Recent studies suggested that anti-CD20 and fingolimod may be associated with lower anti-spike protein-based immunoglobulin-G response following COVID-19 vaccination. We evaluated if occurred despite vaccination among patients multiple sclerosis (MS) neuromyelitis optica (NMO), using the COVISEP registry.We report 18 cases of after two doses BNT162b2-vaccination, 13 which treated four fingolimod. severity was mild.These results reinforce recommendation for a third vaccine dose stress need...
Background: Epidemiologic studies on coronavirus disease 2019 (COVID-19) in patients with multiple sclerosis (pwMS) have focused the first waves of pandemic until early 2021. Objectives: We aimed to extend these data from onset global coverage by vaccination summer 2022. Methods: This retrospective, multicenter observational study analyzed COVISEP registry reported COVID-19 cases pwMS between January 2020 and July Severe was defined as hospitalization or higher severity. Results: Among 2584...
An enhanced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine regimen could improve humoral response in patients with multiple sclerosis (MS) treated by anti-CD20. The aim was to evaluate the serological and neutralizing activity after BNT162b2 primary booster vaccination MS patients, including on anti-CD20 receiving a three injections.In this prospective longitudinal cohort study of 90 (47 anti-CD20, 10 fingolimod, 33 natalizumab, dimethylfumarate or teriflunomide),...
CTLA4 deficiency (CTLA4d) is a disease with multisystem autoimmune features, including neurologic manifestations. We aimed to describe involvement in these patients.
Objective: Particulate matter (PM) of aerodynamic diameter smaller than 10 μm (PM ) has been associated with multiple sclerosis (MS) relapse. However, the impact PM a greater ability to penetrate human organism never assessed. We evaluated 2.5 on risk MS Material and Methods: In case-crossover study, we included 2,109 consecutive hospitalizations likely due relapse in day hospital 5 centers Paris area from January 2009 December 2013. For each hospitalization, natural logarithm average weekly...
Cerebral small-vessel disease (CSVD) is a chronic accounting for one-third of strokes and the second etiology dementia. Despite sustained immunovirological control, CSVD prevalence doubled in middle-aged persons living with HIV (PLHIVs), even after adjustment traditional cardiovascular risk factors. We aimed to investigate whether exposure any antiretroviral drug class could be associated an increasing CSVD.The MicroBREAK-2 case-control study (NCT02210130) enrolled PLHIVs aged 50 years...
Abstract Background Aquaporin-4 immunoglobulin G Neuro Myelitis Optica spectrum disorders attacks (NMOSD-AQP4-IgG+ attacks) can cause respiratory failure requiring orotracheal intubation (OTI), but the risk factors and outcomes of OTI during remain unclear. Our primary objective was to identify clinical radiological for in NMOSD-AQP4-IgG+ attacks. As a secondary objective, we aimed evaluate prognosis OTI-attacks. Methods We retrospectively analyzed at Pitié-Salpêtrière Hospital (Jan 2010–Jan...
Abstract Background Autoimmune manifestations can occur in the context of HIV immune reconstitution inflammatory syndrome (IRIS). Previous studies have shown that GM2 is overexpressed on HIV‐1 infected T lymphocytes. Case presentation A 71‐year‐old patient diagnosed with infection developed neurological symptoms congruent meningoradiculitis 1 month after initiation antiretroviral therapy. Concurrent syphilitic seroconversion raised hypothesis neurosyphilis, which was later infirmed. Serum...