A5046331186- Gut microbiota and health
- Oral microbiology and periodontitis research
- Diet and metabolism studies
- Salivary Gland Disorders and Functions
- Oral Health Pathology and Treatment
- Dental Health and Care Utilization
- Liver Disease Diagnosis and Treatment
- Oral and gingival health research
- Rheumatoid Arthritis Research and Therapies
- Diabetes and associated disorders
- Gastrointestinal motility and disorders
- Dietary Effects on Health
- Periodontal Regeneration and Treatments
- Otolaryngology and Infectious Diseases
- Biochemical Analysis and Sensing Techniques
- Liver Disease and Transplantation
- Gestational Diabetes Research and Management
- Mesenchymal stem cell research
- Hepatitis Viruses Studies and Epidemiology
- Diabetes Management and Education
- Clostridium difficile and Clostridium perfringens research
- Peptidase Inhibition and Analysis
- Metabolomics and Mass Spectrometry Studies
- Bone and Dental Protein Studies
- Exercise and Physiological Responses
Inserm
2015-2024
Institut des Maladies Métaboliques et Cardiovasculaires
2014-2024
Université Toulouse III - Paul Sabatier
2011-2024
Centre Hospitalier Universitaire de Toulouse
2018-2024
Hôpital Rangueil
2021-2023
Institut National de Recherche en Santé Publique
2012-2022
Hôpital Saint-Jacques
2019
Université de Toulouse
2011-2018
Pharmacochimie et Pharmacologie pour le Développement
2012
To identify a causal mechanism responsible for the enhancement of insulin resistance and hyperglycaemia following periodontitis in mice fed fat-enriched diet.We set-up unique animal model C57Bl/6 female by infecting periodontal tissue with specific alive pathogens like Porphyromonas gingivalis (Pg), Fusobacterium nucleatum Prevotella intermedia. The were then diabetogenic/non-obesogenic diet up to 3 months. Alveolar bone loss, microbiota dysbiosis features glucose metabolism quantified....
To examine the potential relationship among gene expression markers of adipose tissue browning, gut microbiota, and insulin sensitivity in humans.Gut microbiota composition browning are analyzed subcutaneous (SAT) visceral (VAT) from morbidly obese subjects (n = 34). Plasma acetate is measured through 1 H NMR using euglycemic hyperinsulinemic clamp. Subjects with resistance show an increase relative abundance (RA) phyla Bacteroidetes Proteobacteria while RA Firmicutes decreased. In all...
Background A fat-enriched diet favors the development of gram negative bacteria in intestine which is linked to occurrence type 2 diabetes (T2D). Interestingly, some pathogenic are commonly associated with periodontitis which, like T2D, characterized by a chronic low-grade inflammation. Moreover, estrogens have been shown regulate glucose homeostasis via an LPS receptor dependent immune-modulation. In this study, we evaluated whether diet-induced metabolic disease would favor mice. addition,...
<h3>Objectives</h3> Association between periodontal disease (PD) and rheumatoid arthritis (RA) has been extensively described, but direct evidence of causal involvement PD in RA is missing. We investigated the priming role oral <i>Porphyromonas gingivalis</i> (<i>P. gingivalis</i>) subsequent we assessed biomarkers bone resorption development rats. <h3>Methods</h3> Lewis rats were orally exposed to either <i>P. gingivalis</i>, <i>Prevotella intermedia</i> or control gel for 1 month then...
Despite the current pandemic of metabolic diseases, our understanding diverse nature development alterations in people who eat a high-fat diet (HFD) is still poor. We recently demonstrated cardio-metabolic adaptation mice fed an HFD, which was characterised by specific gut and periodontal microbiota profile. Since severity hepatic disease microRNA (miRNA) signatures key driver both miRNA expression, we analysed expression three studied their correlation with triacylglycerol content...
To demonstrate that glycemia and insulin resistance are controlled by a mechanism involving the adaptive immune system gut microbiota crosstalk.We triggered with microbial extracts specifically from intestinal ileum contents of HFD-diabetic mice process immunization. 35 days later, immunized were fed HFD for up to two months in order challenge development metabolic features. The responses quantified. Eventually, adoptive transfer cells microbiota-immunized naïve was performed causality...
Abstract Current treatment of periodontitis is still associated with a high degree variability in clinical outcomes. Recent advances regenerative medicine by mesenchymal cells, including adipose stromal cells (ASC) have paved the way to improved periodontal regeneration (PD) but little known about biological processes involved. Here, we aimed use syngeneic ASCs for new, relevant, bacteria-induced model mice. Periodontal defects were induced female C57BL6/J mice oral gavage pathogens. We...
Abstract Some obese subjects overeat lipid-rich foods. The origin of this eating behavior is unknown. We have here tested the hypothesis that these could be characterized by an impaired fatty taste sensitivity linked to a change in gustatory papillae microbial and salivary environment. composition microbiota saliva surrounding circumvallate was analyzed combination with orosensory lipid detection threshold normal weight (NW) (O) adults. Microbial architecture similar what known feces, but...
Abstract Gut microbiota dysbiosis has been implicated in a variety of systemic disorders, notably metabolic diseases including obesity and impaired liver function, but the underlying mechanisms are uncertain. To investigate this question, we transferred caecal from either obese or lean mice to antibiotic‐free, conventional wild‐type mice. We found that transferring obese‐mouse gut on normal chow (NC) acutely reduces markers hepatic gluconeogenesis with decreased PEPCK activity, compared...
To assess whether periodontal treatment can lead to clinical, glycaemic control and quality of life improvements in metabolically unbalanced diabetic patients (type 1 or type 2) diagnosed with periodontitis.In this open-labelled randomized controlled trial, subjects (n = 91) were given "immediate" "delayed" (full-mouth non-surgical scaling root planing, systemic antibiotics, oral health instructions). The main outcome was the effect on glycated haemoglobin (HbA1C ) fructosamine levels....
Periodontitis and type 2 diabetes are connected pandemic diseases, both risk factors for cardiovascular complications. Nevertheless, the molecular relating these two chronic pathologies poorly understood. We have shown that, in response to a long-term fat-enriched diet, mice present particular gut microbiota profiles related three metabolic phenotypes: diabetic-resistant (DR), intermediate (Inter), diabetic-sensitive (DS). Moreover, many studies suggest that dysbiosis of periodontal could be...
Abstract Background Gut microbiota is involved in the development of liver diseases such as fibrosis. We and others identified that selected sets gut bacterial DNA bacteria translocate to tissues, notably liver, establish a non-infectious tissue composed microbial low frequency live bacteria. However, precise set DNA, thereby corresponding taxa associated with early stages fibrosis need be identified. Furthermore, overcome impact different group size patient origins we adapted innovative...
Objective: Rheumatoid arthritis and periodontal disease are associated together, but the effect of therapy provided for one to second remained under-investigated. This study investigated infliximab used treat rheumatoid (RA) on various biomarkers (PD) severity including serologies Porphyromonas gingivalis Prevotella intermedia matrix metalloproteinase 3. Methods: Seventy nine RA patients were enrolled at time start 28 joint activity score (DAS28), anti-cyclic citrullinated petides 2nd...
(1) Background: In developed countries, the prevalence of apical periodontitis (AP) varies from 20% to 50% for reasons that could be associated with microbiota ecology. (2) Methods: We performed a clinical study in Odontology department Toulouse hospital France, sequence 16S rRNA gene AP and collect parameters 94 patients. Forty-four patients were characterized PAI (periapical index severity) score lower or equal 3, while others had superior scores (n = 50). (3) Results: The low diversity...