A5057102344- Rheumatoid Arthritis Research and Therapies
- Shoulder Injury and Treatment
- Spondyloarthritis Studies and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Orthopedic Infections and Treatments
- Autoimmune and Inflammatory Disorders Research
- Spine and Intervertebral Disc Pathology
- Orthopedic Surgery and Rehabilitation
- Psoriasis: Treatment and Pathogenesis
- Shoulder and Clavicle Injuries
- Musculoskeletal pain and rehabilitation
- Infectious Diseases and Tuberculosis
- Tendon Structure and Treatment
- Bone and Joint Diseases
- Musculoskeletal Disorders and Rehabilitation
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
- Osteomyelitis and Bone Disorders Research
- Peripheral Nerve Disorders
- Bone Metabolism and Diseases
- Anesthesia and Pain Management
- Hip disorders and treatments
- Bone health and treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory Myopathies and Dermatomyositis
Inserm
2015-2025
Nantes Université
2015-2025
Centre Hospitalier Universitaire de Nantes
2015-2024
Centre d'Investigation Clinique de Nantes
2012-2024
RMeS - Regenerative Medicine and Skeleton
2023-2024
Oniris
2023-2024
Hôtel-Dieu de Paris
2013-2023
Société Française de Rhumatologie
2017-2023
Hotel Dieu Hospital
2014-2022
Institut Régional de Médecine Physique et de Réadaptation
2021
Interleukin (IL)-36α, IL-36β and IL-36γ are expressed highly in skin involved the pathogenesis of psoriasis, while antagonists IL-36Ra or IL-38, another potential IL-36 inhibitor, limit uncontrolled inflammation. The expression role cytokines rheumatoid arthritis (RA) Crohn's disease (CD) is currently debated. Here, we observed that during imiquimod-induced mouse inflammation human IL-36α, γ IL-36Ra, but not IL-38 mRNA, was induced correlated with IL-1β T helper type 17 (Th17) (IL-17A,...
Objectives Interleukin (IL) 34 is a new cytokine implicated in macrophage differentiation and osteoclastogenesis. This study assessed IL-34 expression the tissue of patients with rheumatoid arthritis (RA). Methods Immunohistochemistry was performed synovial biopsies from RA (n=20), osteoarthritis (n=3) or other inflammatory (n=4). detected fluid by ELISA its messenger RNA studied quantitative PCR fibroblasts after stimulation tumour necrosis factor α (TNFα) IL-1β. Wild-type, jnk1 −/− –jnk2...
Interleukin (IL)-38 is a newly characterised cytokine that belongs to the IL-1 family. This expressed in rheumatoid arthritis (RA) synovial tissue and IL-38 deficient mice have exacerbated arthritis. Here, we analysed effect of overexpression joints arthritic mice, human macrophages fibroblasts vitro.Articular injections an adeno-associated virus (AAV) 2/8 encoding were performed collagen-induced (CIA), K/BxN serum transfer-induced (STIA) antigen-induced (AIA) mice. The was evaluated through...
We undertook this study to examine microRNA (miRNA) expression across rheumatoid arthritis (RA) phenotypes, along with the effects and mechanisms of action miRNA-17-5p (miR-17).A miRNA array was performed in synovial tissue biopsied from patients naive erosive RA (n = 3) nonerosive 3). MicroRNA-17 lipoplex delivered intraarticularly murine collagen-induced model. Clinical, histologic, structural were studied over course arthritis. In-depth studies miR-17 primary fibroblast-like synoviocytes...
Infliximab, an anti-tumour necrosis factor-α monoclonal antibody, is indicated in rheumatoid arthritis (RA). Our objective was to evaluate the influence of sources infliximab pharmacokinetic variability RA.Eighty-four patients treated with for RA were included a prospective noncomparative study. They analysed between two consecutive infusions. Infliximab concentrations measured before infusion, 2 h, 1 and 4 weeks after infusion immediately next infusion. described using two-compartment...
Proinflammatory macrophages and miR-155 are increased in patients with rheumatoid arthritis (RA). We studied membrane TNF (mTNF) expression on blood monocytes, polarization into macrophages, expression, the effect of anti-TNF these biomarkers RA patients. Sixty-seven 109 controls (55 healthy, 54 spondyloarthritis connective tissue diseases) were studied. Monocytes isolated differentiated or without anti-TNF. mTNF was monocytes from patients, but not other inflammatory diseases, correlated...
Abstract RANK, RANK ligand (RANKL) and osteoprotegerin (OPG) are the key regulators of bone metabolism, both in normal pathological conditions. Previous data have demonstrated that human osteosarcoma biopsies express RANKL as well OPG, functional is expressed a murine cell line. As expression remains controversial, aim present study was to analyse its vitro lines, ex vivo using tissues, then determine functionality terms signal transduction pathways modulated by RANKL. RT‐PCR analysis...
Anticitrullinated peptide/protein antibodies (ACPA), which are highly specific for rheumatoid arthritis (RA), may be found in some patients with other systemic autoimmune diseases. The clinical significance of ACPA antisynthetase syndrome (ASS), a disease characterized by the association myositis, interstitial lung disease, polyarthralgia, and/or polyarthritis, has not yet been evaluated regard to phenotype, prognosis, and response treatment. ACPA-positive ASS were first identified among...
Macrophages and synovial fibroblasts (SF) are two major cells implicated in the pathogenesis of rheumatoid arthritis (RA). SF could be a source cytokines growth factors driving macrophages survival activation. Here, we studied effect on monocyte viability phenotype.SF were isolated from tissue RA patients CD14+ peripheral blood healthy donors. conditioned media collected after 24 hours culture with or without stimulation TNFα IL-1β. polarisation was by flow cytometry.Conditioned medium...