A5070019661- MicroRNA in disease regulation
- RNA Research and Splicing
- Sarcoma Diagnosis and Treatment
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Cell Adhesion Molecules Research
- Protein Degradation and Inhibitors
- Cytokine Signaling Pathways and Interactions
- Ion channel regulation and function
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Cancer-related gene regulation
- Protease and Inhibitor Mechanisms
- TGF-β signaling in diseases
- Histone Deacetylase Inhibitors Research
- Cardiovascular Effects of Exercise
- Genomics and Chromatin Dynamics
- Rheumatoid Arthritis Research and Therapies
- Adrenal and Paraganglionic Tumors
- Caveolin-1 and cellular processes
- Cancer, Hypoxia, and Metabolism
- Viral-associated cancers and disorders
- Multiple Myeloma Research and Treatments
- HER2/EGFR in Cancer Research
Nantes Université
2008-2024
Inserm
2011-2024
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
2022-2024
Centre National de la Recherche Scientifique
2015-2024
Université d'Angers
2023
PhysioPathologie des Adaptations Nutritionnelles
2019
Centre Hospitalier Universitaire de Nantes
2013
La Ligue Contre le Cancer
2013
We undertook this study to examine microRNA (miRNA) expression across rheumatoid arthritis (RA) phenotypes, along with the effects and mechanisms of action miRNA-17-5p (miR-17).A miRNA array was performed in synovial tissue biopsied from patients naive erosive RA (n = 3) nonerosive 3). MicroRNA-17 lipoplex delivered intraarticularly murine collagen-induced model. Clinical, histologic, structural were studied over course arthritis. In-depth studies miR-17 primary fibroblast-like synoviocytes...
Vascular calcification is a strong and independent predictive factor for cardiovascular complications mortality. Our previous work identified important discrepancies in plaque composition types between carotid femoral arteries. The objective of this study to further characterize understand the heterogeneity vascular among beds, identify molecular mechanisms underlying process. We established ECLAGEN biocollection that encompasses human atherosclerotic lesions healthy arteries from different...
Ewing sarcoma (ES) is characterized by EWS::FLI1 or EWS::ERG fusion proteins. Knowing that ion channels are involved in tumorigenesis, this work aimed to study the involvement of KCNN1 gene, which encodes SK1 potassium channel, ES development. Bioinformatics analyses from databases were used expression patients and cell lines. Molecular approaches vitro assays transcriptional regulation its proliferation. overexpressed patient biopsies, inversely correlated with survival. EWS::FLI1, like...
// Steven Georges 1, 2, * , Lidia Rodriguez Calleja Camille Jacques Melanie Lavaud 2 Brice Moukengue Fernando Lecanda 3 Thibaut Quillard Marta Tellez Gabriel 6 Pierre-François Cartron 4, 5, 6, 7 Marc Baud'huin François Lamoureux Dominique Heymann and Benjamin Ory 1 INSERM, UMR-S 1238, Nantes 44035, France PhyOs, Sarcomes Osseux et Remodelage des Tissus Calcifiés, Université de Nantes, Division of Oncology, Adhesion Metastasis Laboratory, Center for Applied Medic al Research, University...
The viral G protein-coupled receptor (vGPCR) is proposed to act as one of the predominant mediators Kaposi's sarcoma (KS), a human herpes virus 8 (HHV8)-elicited disease. actions vGPCR manifest pathogenesis, in part, through increased permeability endothelial cells. Endothelial cell-cell junctions have indeed emerged an instrumental target involved vasculature defects observed within tumor microenvironment. pathway leading adherens junction destabilization has been shown involve activation...
Background: Osteoclasts are major actors in the maintenance of bone homeostasis. The full functional maturation osteoclasts from monocyte lineage cells is essential for degradation old/damaged matrix. Diuron one most frequently encountered herbicides, particularly water sources. However, despite a reported delayed ossification vivo, its impact on remains largely unknown. Objectives: objectives this study were to first better characterize osteoclastogenesis by identifying genes that drive...
Ewing sarcoma (ES), the second main pediatric bone sarcoma, is characterised by a chromosomal translocation leading to formation of fusion proteins like EWS::FLI1. While several studies have shown that potassium channels drive development many tumours, limited data exist on ES. This work therefore aimed study transcriptional regulation KCNA2 and define involvement Kv1.2 channel encoded in key function ES development, cell proliferation. expression patients lines was measured via...
Abstract Ewing sarcoma (ES) is characterized by chimeric fusion proteins, which act as oncogenes. Over the last decade, patient survival has not increased, especially for high risk patients. Knowing that ion channels are studied their implication in tumorigenesis, aim of this work to study involvement SK1 potassium ES. RNA-Seq analyses showed a restricted expression KCNN1 , gene encoding SK1, only ES patients, and its inversely correlated with survival. EWS-FLI1 silencing demonstrated...
Abstract Bone pathologies exhibit diverse and often combined genetic, hormonal, inflammatory environmental origins. These (osteopetrosis, osteolysis expensive, Paget ‘s disease, osteoporosis, rheumatoid arthritis, bone cancer…), affecting altogether millions peoples around the world, correspond to local or generalized imbalance of differentiation/function cells in charge apposition (osteoblasts) resorption (osteoclasts). Therefore, identification new mechanisms therapeutic targets constitute...
Abstract Super enhancers are strong spatiotemporal transcriptional regulators. They can be mapped on genomes thanks to their astounding enrichment for well-known markers, such as acetylation of the lysine 27 type 3 histones (H3K27Ac). Their target genes, confined in so-called topologically associated domains, present exceptionally high expression levels, depending super activation status, and responsible defining cells identity whether physiological or pathological. Osteosarcomas most common...
Abstract The use of poly-chemotherapy combined with surgical resection has good efficiency and increased the survival rates osteosarcoma (OS) patients to 70%, however these have not evolved since 1970’s. On other hand, drops 30% among metastases and/or bad response treatment. This suggests that metastasis resistance treatment are key obstacles tackle in order reduce mortality. In this context study aim identify mechanisms could participate emergence doxorubicin, one most often used...