A5058962112- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Shoulder Injury and Treatment
- Orthopedic Surgery and Rehabilitation
- Osteoarthritis Treatment and Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Bone health and treatments
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- Orthopedic Infections and Treatments
- Bone and Joint Diseases
- Osteomyelitis and Bone Disorders Research
- Bone health and osteoporosis research
- Infectious Diseases and Tuberculosis
- Bone Metabolism and Diseases
- Shoulder and Clavicle Injuries
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal synovial abnormalities and treatments
- Urticaria and Related Conditions
- Parathyroid Disorders and Treatments
- Pain Management and Placebo Effect
- Orthopaedic implants and arthroplasty
- Health, Medicine and Society
Nantes Université
2011-2025
Centre Hospitalier Universitaire de Nantes
2016-2025
Inserm
2010-2025
Centre d'Investigation Clinique de Nantes
2012-2024
Oniris
2019-2024
Lantiq (Germany)
2024
RMeS - Regenerative Medicine and Skeleton
2022-2023
Hotel Dieu Hospital
2020-2021
Centre Antoine Lacassagne
2020
Hôtel-Dieu de Paris
2001-2019
Despite previously carrying out a first open study of sacroiliac injection long-acting corticosteroid, it was not possible to evaluate the role placebo effect. We therefore performed double-blind in 10 patients/13 articulations, suffering painful sacroiliitis. At 1 month, 5/6 joints injected with corticosteroid described relief >70%, comparison 0/7 group (P < 0.05). Dolometry showed marked decrease from (mean ± S.E.M.) 6.8 0.6 1.3 0.3, and decreases were mild group: 7.0 5.2 0.5 0.005). Six...
<h3>Aim</h3> To test the efficiency of tumour necrosis factor blockers (adalimumab) in patients with painful refractory (non-responders to analgesics and non-steroidal anti-inflammatory drugs (NSAIDs)) hand osteoarthritis (OA). <h3>Methods</h3> We performed a randomised, double-blind, placebo-controlled, parallel group, multicentre study. Patients were randomised to: 1/1 adalimumab 40 mg for two subcutaneous injections at 15-day interval or placebo monitored 6 months. The primary outcome was...
Abstract Objective To evaluate the efficacy and tolerability of a single intraarticular (IA) injection hyaluronic acid (HA) for treatment hip osteoarthritis (OA). Methods A multicenter, randomized, parallel‐group, placebo‐controlled trial was conducted over 3 months. Patients (older than 30 years) with symptomatic OA (pain score >40 mm on visual analog scale [VAS]) Kellgren/Lawrence grade 2 or were randomly assigned to receive 1 fluoroscopically guided IA HA (2.5 ml) placebo ml). followed...
<h3>Objectives</h3> To assess the efficacy of a single intradiscal injection allogeneic bone marrow mesenchymal stromal cells (BM-MSCs) versus sham placebo in patients with chronic low back pain (LBP). <h3>Methods</h3> Participants were randomised prospective, double-blind, controlled study to receive either or 20 million BM-MSC, between April 2018 and December 2022. The first co-primary endpoint was rate responders defined by improvement Visual Analogue Scale (VAS) for at least 20% mm,...
The concept of fibromyalgia has progressed to achieve a certain consensus regarding the definition condition. We summarize what is known in 2020, be it terms diagnosis, with criteria that have changed over years, or at level psychological profile, via notions “catastrophizing” and “coping” post-traumatic syndrome. importance fatigue sleep disorders underlined, chronological sequence syndrome, chronic fatigue, then amplification pain onset multiple associated symptoms. etiopathogenic debate...
Objective To evaluate the effect of a nurse-led patient education on safety skills patients with inflammatory arthritis treated biologic disease-modifying antirheumatic drugs (bDMARDs). Methods This is multicentre, open-labelled, randomised controlled trial comparing an intervention group (face-to-face by nurse at baseline and 3 months later) control (usual care) introduction first subcutaneous bDMARD. The primary outcome was score BioSecure questionnaire 6 (0–100 scale), validated assessing...
Abstract Introduction Osteoclasts play a key role in the pathogenesis of bone erosion and systemic mass loss during rheumatoid arthritis (RA). In this study, we aimed to determine effect methotrexate (MTX) zoledronic acid (ZA), used alone or combination, on osteoclast-mediated erosions rat model collagen induced (CIA). We hypothesized that MTX ZA could have an additive prevent both loss. Methods Arthritis was 64 female Sprague-Dawley rats. After clinical onset CIA, rats were assigned...
Osteoporosis is characterized by low bone mineral density (BMD) and fragility fracture affects over 200 million people worldwide. Bone quality describes the material properties that contribute to strength independently of BMD, its quantitative analysis a major priority in osteoporosis research. Tissue mineralization fundamental process requiring calcium phosphate transporters. Here we identify impaired Slc20a2-/- mice lacking transporter SLC20A2. Juveniles had abnormal endochondral...