A5044555520- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Systemic Lupus Erythematosus Research
- Adolescent and Pediatric Healthcare
- Vasculitis and related conditions
- Inflammasome and immune disorders
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Chronic Lymphocytic Leukemia Research
- Peripheral Neuropathies and Disorders
- Microbial infections and disease research
- Diphtheria, Corynebacterium, and Tetanus
- Pregnancy and Medication Impact
- Pharmaceutical studies and practices
- Animal Virus Infections Studies
- Monoclonal and Polyclonal Antibodies Research
- Reproductive System and Pregnancy
- SARS-CoV-2 and COVID-19 Research
- Ocular Diseases and Behçet’s Syndrome
- Peripheral Artery Disease Management
- Kawasaki Disease and Coronary Complications
- Gout, Hyperuricemia, Uric Acid
- Otitis Media and Relapsing Polychondritis
- Mycobacterium research and diagnosis
Algarve Biomedical Center
2015-2024
Center for Rheumatology
2023
University of Algarve
2023
Hospital Ramos Mejía
2023
Hospital de Faro EPE
2014-2022
Hospital de Santa Maria
2001
Moredun Research Institute
1995
The Ohio State University
1995
<h3>Aim</h3> To determine characteristics associated with more severe outcomes in a global registry of people systemic lupus erythematosus (SLE) and COVID-19. <h3>Methods</h3> People SLE COVID-19 reported the Global Rheumatology Alliance from March 2020 to June 2021 were included. The ordinal outcome was defined as: (1) not hospitalised, (2) hospitalised no oxygenation, (3) any ventilation or oxygenation (4) death. A multivariable logistic regression model constructed assess relationship...
Objectives To assess the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy psoriatic arthritis (PsA) dactylitis. Methods Multicentre, investigator-initiated, randomised, double-blind, placebo-controlled, parallel-design phase 3b trial 11 Portuguese rheumatology centres. Patients PsA along active dactylitis and naive to biologic disease-modifying antirheumatic drugs (bDMARDs) were randomly assigned or placebo, both MTX. The primary endpoint was Dactylitis...
Text embeddings are typically evaluated on a limited set of tasks, which constrained by language, domain, and task diversity. To address these limitations provide more comprehensive evaluation, we introduce the Massive Multilingual Embedding Benchmark (MMTEB) - large-scale, community-driven expansion MTEB, covering over 500 quality-controlled evaluation tasks across 250+ languages. MMTEB includes diverse challenging, novel such as instruction following, long-document retrieval, code...
Background: Although the survival rate has considerably improved, many patients with systemic lupus erythematosus (SLE) develop irreversible organ damage. Objectives: The objectives of this paper are to characterize cumulative damage in SLE and identify variables associated its presence severity. Methods: A cross-sectional analysis from Portuguese Lupus register Reuma.pt/SLE whom assessment using SLICC/ACR-Disability Index (SDI) was available performed. Predictor factors for damage, defined...
Objective To evaluate whether use of comedication with conventional synthetic disease‐modifying antirheumatic drugs (csDMARDs) influences the retention tumor necrosis factor inhibitors (TNFi) in patients spondyloarthritis (SpA). Methods Patients SpA from Rheumatic Diseases Portuguese Register who started treatment their first TNFi between 2001 and 2014 were included this study. Cox regression analysis was used to estimate effect csDMARDs on 2 types models: a model which baseline (time‐fixed)...
Low-dose weekly methotrexate (MTX) is the mainstay in therapy of rheumatoid arthritis (RA). It can be given via oral, intramuscular or subcutaneous (SC) route. This study sought to determine real-world pattern treatment with SC MTX Portuguese adult patients active RA. Utilization Metoject® Rheumatoid Arthritis (UMAR) was a non-interventional, cohort multicenter retrospective data collection. Eligible had RA, at least 18 years age, and started 2009 2010 after failure intolerance oral MTX....
Objectives. Assess the effectiveness and safety of biologic therapy as well predictors response at 1 year therapy, retention rate in treatment drug discontinuation JIA patients Portuguese register rheumatic diseases. Methods. We prospectively collected patient disease characteristics from with who started biological therapy. Adverse events were during follow-up period. Predictors rates assessed 4 years for first agent. Results. A total 812 [65% females, mean age onset 6.9 (s.d. 4.7)], 227...
To compare physical disability, mental health, fatigue and health-related quality of life (HRQoL) across juvenile idiopathic arthritis (JIA) categories in adulthood between JIA adult-onset rheumatic diseases.Cross-sectional analysis nested a cohort adult patients with registered the Rheumatic Diseases Portuguese Register (Reuma.pt). Physical disability (Health Assessment Questionnaire-Disability Index), health symptoms (Hospital Anxiety Depression Scale), (Functional Chronic Illness...
Abstract Background Juvenile idiopathic arthritis (JIA) treatment is aimed at inducing remission to prevent joint destruction and disability. However, it unclear what the long-term impact on health-related outcomes of timing biological disease-modifying antirheumatic drug (bDMARD) initiation in JIA. Our aim was evaluate time between JIA onset a bDMARD achieving clinical remission, physical disability quality life (HRQoL). Methods Adult patients registered Rheumatic Diseases Portuguese...
Abstract Background The vasculitides are a group of rare diseases with different manifestations and outcomes. New therapeutic options have led to the need for long-term registries. Rheumatic Diseases Portuguese Register, Reuma.pt, is web-based electronic clinical record, created in 2008, which currently includes specific modules 12 > 20,000 patients registered from 79 rheumatology centres. On October 2014, dedicated module vasculitis was as part European Vasculitis Society collaborative...
Objective: We aim to study association between neutrophile lymphocyte (NLR) and platelet (PLR) ratios disease activity, their value predict bDMARD response. Methods: A set of spondylarthritis (SpA) patients under registered in the Reuma.pt registry was studied. Sociodemographic, clinical laboratorial variables were assessed on initiation, 6, 12, 18 24 months (M) thereafter. Univariable multivariable generalized estimation equations models associations with activity. The NLR PLR predictive...
To identify risk factors for SARS-CoV-2 infection and severe/critical COVID-19, to assess the humoral response after COVID-19 in these patients.
Objective We aim to study association between neutrophile lymphocyte (NLR) and platelet (PLR) ratios disease activity, their value predict bDMARD response.Methods A set of spondylarthritis (SpA) patients under registered in the Reuma.pt registry was studied. Sociodemographic, clinical laboratorial variables were assessed on initiation, 6, 12, 18 24 months (M) thereafter. Univariable multivariable generalized estimation equations models associations with activity. The NLR PLR predictive using...
<h3>Background</h3> The vasculitides are a group of relatively rare diseases with different manifestations and outcomes. New therapeutic options have led to the need for long-term registries. Rheumatic Diseases Portuguese Register, Reuma.pt, is an electronic clinical record, created in 2008, which currently includes specific protocols 11 >16000 patients registered from 79 national international rheumatology centres. Since October 2014, dedicated protocol vasculitis has been as part...
<h3>Background</h3> Systemic lupus erythematosus (SLE) is a multi-organ immune-mediated disease that affects predominantly women at reproductive age but may present itself any age. Age onset has strong modulating effect on clinical presentation and course of disease. Although young patients have more aggressive disease, controversies persist regarding the impact SLE outcome. <h3>Objectives</h3> Characterize childhood-onset, adult-onset late-onset assess whether outcome differs in these three...