A5049258748- Traumatic Ocular and Foreign Body Injuries
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Facial Trauma and Fracture Management
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Restraint-Related Deaths
- Retinal and Optic Conditions
- Child Abuse and Related Trauma
- Cerebral Venous Sinus Thrombosis
- Ocular and Laser Science Research
- Vascular Malformations Diagnosis and Treatment
- Drug-Induced Ocular Toxicity
- Ocular Diseases and Behçet’s Syndrome
- Retinopathy of Prematurity Studies
- Ophthalmology and Visual Health Research
- Virus-based gene therapy research
- Neuroscience and Neural Engineering
- CRISPR and Genetic Engineering
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Ophthalmology and Eye Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
University of Alabama at Birmingham
2011-2023
University of Alabama
1987-2013
Helen Keller Foundation
1990-2009
California Pacific Medical Center
2006
Retina Specialists
2004-2006
University of Alabama at Birmingham Hospital
1986-1997
Menlo School
1994
International Retinal Research Foundation
1987-1988
Temple University
1965
University Medical Center
1965
To analyze the epidemiology and clinical characteristics of serious eye injuries leading to legal blindness.Analysis information on 11,320 eyes in United States Eye Injury Registry (USEIR) database. Legal blindness this study was defined as visual acuity worse than 20/200.No less 27% with injury had < 20/200 final vision, although rate varied greatly type. Several risk factors were found statistically significantly increase chance trauma resulting blindness: age over 60 years, by assault,...
The public health success of diabetic retinopathy (DR) screening programs depends on patients' adherence to the timetable follow-up eye care recommended by program. African Americans are among those at highest risk for DR and have one lowest rates use.To assess rate adhering in a program administered safety-net facility examine factors associated with use.Prospective study persons type 1 or 2 diabetes. setting was an internal medicine clinic publicly funded system Alabama, serving population...
Adeno-associated virus (AAV) has proven an effective gene delivery vehicle for the treatment of retinal disease. Ongoing clinical trials using a serotype 2 AAV vector to express RPE65 in pigment epithelium have safe and effective. While many proof-of-concept studies animal models disease suggested that transfer neural retina will also be effective, photoreceptor-targeting yet used clinic, principally because efficiently but exclusively targets all primate photoreceptors demonstrated. Here,...
Mutations in
Adeno-associated virus (AAV) has emerged as the preferred vector for targeting gene expression to retina. Subretinally injected AAV can efficiently transduce retinal pigment epithelium and photoreceptors in primate Inner middle retina be transduced by intravitreally delivered AAV, but with low efficiency. This is due dilution of vector, potential neutralization capsid because it not confined immune-privileged compartment, presence inner limiting membrane (ILM), a barrier separating vitreous...
X-linked retinitis pigmentosa (XLRP) caused by mutations in the RPGR gene is an early onset and severe cause of blindness. Successful proof-of-concept studies a canine model have recently shown that development corrective therapy for RPGR-XLRP may now be attainable goal. In preparation future clinical trial, we here optimized therapeutic AAV vector construct showing GRK1 (rather than IRBP) more efficient promoter targeting expression to both rods cones non-human primates. Two transgenes were...
Purpose.: Delayed rod-mediated dark adaptation (DA) is characteristic of early age-related macular degeneration (AMD) and also can be observed in some older adults normal health. We examine cross-sectional associations between DA risk factors for AMD Methods.: The sample consisted aged ≥60 years old health per grading fundus photos using an established disease classification system. Rod-mediated was measured psychophysically following a photobleach computer-automated adaptometer with targets...
To evaluate a new surgical technique for traumatic macular holes and to provide epidemiological information such holes.Vitrectomy with internal limiting membrane (ILM) removal but without adjuvant use on 17 consecutive eyes.The hole closed in 100% of eyes. Vision improved > or = 2 Snellen lines 16 eyes (94%). The macula showed additional trauma-related damage 10 (59%). No permanent complication related ILM was seen. Among 4440 contusion trauma the United States Eye Injury Registry, risk...
OBJECTIVE. To analyze and compare epidemiological clinical information on serious fireworks-related eye injuries from two affiliates of the United States Eye Injury Registry. METHOD. Retrospective review. RESULTS. In Registry Alabama (EIRA) database, 185 4150 (4.4%) were caused by fireworks. Hungarian only 1245 cases (0.1%, p=0.000001) fireworks-related. EIRA, 79% patients males 87% under 31 years. A bystander was injured in 67% cases, being an average 23 feet away; 39% bystanders had a...