A5000038722- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Ocular Oncology and Treatments
- Intraocular Surgery and Lenses
- Optical Coherence Tomography Applications
- Corneal surgery and disorders
- Vascular Malformations Diagnosis and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Visual Impairment Studies
- Intracranial Aneurysms: Treatment and Complications
- Drug-Induced Ocular Toxicity
- Systemic Sclerosis and Related Diseases
- Cerebrovascular and Carotid Artery Diseases
- Cancer-related Molecular Pathways
- Renal and Vascular Pathologies
- Cardiovascular Health and Disease Prevention
- Ocular Surface and Contact Lens
- Neurological Complications and Syndromes
- Biomedical Research and Pathophysiology
- Systemic Lupus Erythematosus Research
Vita-Salute San Raffaele University
2012-2022
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2017-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2017-2022
IRCCS Ospedale San Raffaele
2010-2020
Bayer (Switzerland)
2020
Roche (Switzerland)
2020
Novartis (Switzerland)
2020
Sanofi (France)
2020
Roche (United States)
2020
Bausch & Lomb (France)
2020
To investigate the changes in macular choroidal thickness eyes with various stages of diabetic retinopathy, using enhanced depth imaging optical coherence tomography (EDI OCT).Sixty-three consecutive patients--who presented without retinopathy (NDR); (nonproliferative [NPDR]) and no clinically significant edema (CSME-); or NDPR (CSME+)--underwent EDI OCT. Twenty-one age- sex-matched healthy subjects (21 eyes) also underwent OCT.A total 63 patients (26 female [41.2%]; mean age 65 ± 9 years,...
The relationship between the presence of peripheral chorioretinal changes and axial myopia in 513 eyes (513 patients) 24 mm or more length, beyond upper range normal is studied. Axial length was measured with A-scan ultrasonography (immersion technique) retinal periphery studied by biomicroscopic examination scleral indentation. lattice degeneration, pavingstone pigmentary white without pressure (WWP), holes, tears, both (RHT), detachment, posterior vitreous detachment reported. correlation...
The clinical utility of new optical coherence tomography (OCT) instruments strongly depends on measurements reproducibility. aim this study was to assess retinal nerve fiber layer (RNFL) thickness reproducibility using six different spectral-domain OCTs (SD-OCTs) and one time-domain OCT.RNFL (average four quadrant) from SD-OCTs (Spectral OCT/SLO OPKO/OTI, 3D-OCT 2000 Topcon, RS-3000 NIDEK, Cirrus HD-OCT Zeiss, RTVue-100 Optovue, Spectralis Heidelberg) OCT (Stratus Zeiss) measured twice in 38...
<h3>Aims</h3> To describe the vascular abnormalities in patients affected by retinitis pigmentosa (RP) means of optical coherence tomography angiography (OCT-A). <h3>Methods</h3> Cross-sectional case series; with RP presenting at Medical Retina Service Department Ophthalmology, University Vita-Salute San Raffaele Milan were recruited. Inclusion criteria were: diagnosis RP, clear ocular media, adequate pupillary dilation, and stable fixation. Patients underwent best-corrected visual acuity...
<h3>Aims</h3> To describe the vascular abnormalities in patients affected by Stargardt disease (STGD1) means of optical coherence tomography angiography (OCT-A). <h3>Methods</h3> Cross-sectional case series, with following inclusion criteria: diagnosis STGD1, clear ocular media, and stable fixation. Patients underwent best-corrected visual acuity (BCVA), biomicroscopy, applanation tonometry, short-wavelength fundus autofluorescence (SW-FAF) (HRA Heidelberg, Germany), 3×3 Swept Source OCT-A...
In Brief Purpose: To analyze the presence of hyperreflective foci in Type 1 and 2 diabetic patients, separately, without clinically significant macular edema visual impairment. Methods: Noninvasive, observational prospective study. Seventeen 19 consecutive patients (33 38 eyes), respectively, were recruited. All had no or Two age- sex-matched control groups also included. Patients underwent an ophthalmologic examination including spectral domain optical coherence tomography. Hyperreflective...
Purpose 1) To compare macular thickness (MT) by optical coherence tomography (OCT) in diabetics and controls; 2) to assess the relationship between MT stage of diabetic retinopathy (DR) edema (ME); 3) quantify changes after laser treatment for ME. Methods One-hundred thirty-seven patients with diabetes mellitus (216 eyes) were admitted study examined stereo-color fundus photos, retinal fluorangiography OCT. DR was classified as: no (46 eyes: 21.3%); background (66 30.6%); pre-proliferative...
Patients with Leber's hereditary optic neuropathy (LHON) have loss of central vision severe damage small-caliber fibers the papillomacular bundle and nerve atrophy. The aim this study was to define presence topographical distribution brain grey matter (GM) white (WM) injury in LHON patients using voxel-based morphometry (VBM). correlation such changes neuro-ophthalmologic findings measurements peripapillary retinal fiber layer (RNFL) thickness by optical coherence tomography (OCT) also...
<b><i>Background:</i></b> To report the morphological macular findings detected by spectral domain optical coherence tomography (SD-OCT) and to determine their prevalence in patients with retinitis pigmentosa (RP). <b><i>Methods:</i></b> SD-OCT scans of 176 eyes from 90 affected RP were reviewed. A careful evaluation was carried out on photoreceptor inner/outer segment (IS/OS) junction, external limiting membrane (ELM), inner thickening (ILMT),...
Plasma and ventricular cerebrospinal fluid (CSF) Beta-endorphin concentrations were evaluated after chromatographic separation in patients carrying a shunt before the administration of diclofenac orplacebo. In same subjects CSF serotonin catecholamine metabolites 5-hydroxyindole-acetic acid (5-HIAA), homovanillic (HVA) MOPEG also evaluated. Plasma, but not ventricular, increased significantly diclofenac, while placebo was ineffective. No significant changes 5-HIAA, HVA or levels observed....
To investigate the early neurodegenerative changes of inner retina and choroid in type 1 2 diabetic patients without retinopathy with early-stage retinopathy.In this observational cross-sectional study, 90 right eyes naive (DR) mild to moderate nonproliferative DR (NPDR) were analyzed. Forty healthy included as controls. We used spectral-domain optical coherence tomography evaluate ganglion cell complex (GCC) thickness, retinal nerve fiber layer (RNFL) central foveal thickness (CFT)...
The aim of this study was to perform quantitative optical coherence tomography angiography (OCTA) assessment arteritic and non-arteritic anterior ischemic optic neuropathies (AION; NAION). designed as an observational, cross-sectional case series. All patients underwent complete ophthalmologic evaluation including LogMAR best-corrected visual acuity (BCVA), structural (OCT) OCTA images, dye-based angiography. Retinal nerve fiber layer (RNFL) thickness obtained from OCT, vessel density (VD)...
A total of 58 patients (116 eyes) with angioid streaks, referred to this department over 2 years (1990–1992), underwent a thorough ophthalmic examination, retinal fluorescein angiography, dermatological visit skin biopsy, and series other examinations (blood biochemistry, skull X-ray, vascular echo Doppler, abdominal ultrasound) eye ultrasonography. Fifty (100 eyes, 86.2%) had pseudoxanthoma elasticum (PXE). In the whole caselist, 21.6% drusen compared 21.0% in group PXE. Both these findings...
Abstract. The aim of this study was to verify if lens thickness in insulin‐dependent diabetic patients is greater than non‐diabetics, and establish which parameters affect the age, diabetes duration, glycaemic control, insulin dose. Ultrasound biometry blood glucose measurements were taken 87 three times a day: fasting 2 4 h after lunch. patient sample divided into groups: 30 with no retinopathy, presented background retinopathy 27 proliferative retinopathy; normal subjects similar age...
This study was designed to compare the effects of subthreshold laser treatment (STLT) with threshold (TLT) in patients affected by symptomatic retinal arterial macroaneurism (RAM).Patients RAM, characterized exudative manifestations involving fovea and best-corrected visual acuity (BCVA) worse than 20/80 Snellen equivalent, were recruited. Patients randomly assigned STLT or TLT regularly followed up for 12 months. Primary outcome measures changes central point thickness (CPT) at end...
<h3>Purpose</h3> To investigate the possible differences in choroidal thickness (CT) between non-neovascular (NNV) and neovascular (NV) age-related macular degeneration (AMD). <h3>Methods</h3> A retrospective, observational chart review of consecutive patients diagnosed with NNV AMD one eye NV fellow was carried out. classified into four subgroups according to Beckman Initiative for Macular Research Classification Committee Meeting. CT manually assessed using enhanced depth imaging optical...