A5033870322- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Connexins and lens biology
- Corneal surgery and disorders
- Allergic Rhinitis and Sensitization
- Advancements in Transdermal Drug Delivery
- Spectroscopy Techniques in Biomedical and Chemical Research
- Dermatology and Skin Diseases
- Retinal Development and Disorders
- Lipid Membrane Structure and Behavior
- Contact Dermatitis and Allergies
- Intraocular Surgery and Lenses
- Retinal Diseases and Treatments
- Biochemical effects in animals
- Facial Rejuvenation and Surgery Techniques
- Urticaria and Related Conditions
- COVID-19 and healthcare impacts
- Ocular Infections and Treatments
- Advanced MRI Techniques and Applications
- Mast cells and histamine
- Dermatologic Treatments and Research
- Infection Control and Ventilation
- Drug-Induced Adverse Reactions
- Nasolacrimal Duct Obstruction Treatments
Smith-Kettlewell Eye Research Institute
2014-2025
Massachusetts Eye and Ear Infirmary
2015-2025
Harvard University
2012-2025
Massachusetts Eye Research and Surgery Institute
1988-2025
Tufts University
2017-2024
Andover Eye Associates
2023
Midwestern University
2000-2022
Ocular Surface Center
2003-2022
Johns Hopkins University
2021
Johns Hopkins Medicine
2021
To evaluate the safety and effectiveness of LipiFlow System compared to iHeat Warm Compress (WC) for adults with meibomian gland dysfunction (MGD).This was a non-significant risk, prospective, open-label, randomized, crossover multicenter clinical trial. One hundred thirty-nine subjects were randomized between (n=69) WC control (n=70). Subjects in group received 12-minute treatment reexamined at 1 day, 2 weeks 4 weeks. Control 5-minute instructions perform same daily At weeks, they crossed...
Objectives. The lid wiper is defined as that portion of the marginal conjunctiva upper eyelid wipes ocular surface during blinking. purpose this study was to investigate whether epitheliopathy occurred with patients who reported dry eye symptoms, yet had normal fluorescein breakup time (FBUT) and Schirmer test values an absence corneal staining. Methods. One hundred were divided into two groups based on presence or determined Standard Patient Evaluation Eye Dryness questionnaire. Other...
Alterations in the tear film lipid layer as a function of blinking were investigated using custom-designed specular reflection monitoring system. The 104 subjects under conditions normal ("baseline") and "forceful" was quantitated on basis specific interference colors. Deliberate, forceful found to significantly increase thickness (LLT) film. magnitude be correlated with baseline LLT values; individuals values 75-150 nm demonstrated mean 33 following blinking, whereas < or = 60 experienced...
To evaluate whether dry-eye symptoms are associated with epitheliopathy of that portion the upper eyelid marginal conjunctiva-the lid wiper-that wipes ocular, or contact lens surface, during blinking.Subjects were divided into two groups based on presence absence symptoms. The wiper asymptomatic (n=75) and symptomatic (n=30) soft wearers was examined, following instillation fluorescein rose bengal dyes. Lid-wiper staining graded zero to 3.Eighty percent subjects displayed lid-wiper compared...
Purpose. Warm-compress therapy applied to the skin of closed eyelids has been recommended as a treatment for meibomian gland dysfunction (MGD). Previous studies have evaluated effects warm-compress on tear-film fluorescein break-up time and tear evaporation rate. The purpose this study was determine if lipid layer thickness (TFLLT) altered following 5, 15, 30 minutes warm, moist compress therapy. Methods. Twenty patients with diagnosis dry eye associated MGD baseline TFLLT ≤ 90 nm (baseline...
(1) To investigate the relationship between dry eye symptoms and lipid layer thickness (LLT) in patients presenting for routine examination (2) to consider practicality of interferometry a clinical practice.Patients consecutively examinations were recruited (n = 137, age range 18-60 years, mean 41.7 +/- 15.5 102 females 35 males). Patients required complete Standard Patient Evaluation Eye Dryness (SPEED) questionnaire after which their LLT was evaluated using new interferometer (Ocular...
Purpose: To evaluate the effect of a single treatment with LipiFlow® Thermal Pulsation System on signs meibomian gland dysfunction (MGD) and dry eye symptoms over 9-month period.Methods: Patients (n = 42 eyes, 21 subjects) diagnosed MGD were recruited for non-significant risk, prospective, open-label, 1-month clinical trial. received 12-minute using each eye. The device applies heat to conjunctival surfaces upper lower inner eyelids while simultaneously applying pulsatile pressure outer...
Crystalline lens and striated muscle exist at opposite ends of the metabolic spectrum. Lens is a metabolically quiescent tissue, whereas mechanically dynamic tissue with high-energy requirements, yet both tissues contain millimolar levels ATP (>2.3 mM), far exceeding their underlying needs. We explored intracellular concentrations across multiple cells, tissues, species, domains to provide context for interpreting lens/striated data. Our database revealed that high are ubiquitous diverse...
The objective of this study was to evaluate the safety and intraocular pressure (IOP)-lowering effects over 24 months biodegradable bimatoprost sustained-release implant (Bimatoprost SR) administration versus topical 0.03% in patients with open-angle glaucoma (OAG).This a phase I/II, prospective, 24-month, dose-ranging, paired-eye controlled clinical trial. At baseline following washout, adult OAG (N = 75) received Bimatoprost SR (6, 10, 15, or 20 µg) intracamerally eye; fellow eye once...
Purpose. Because the lipid layer of tear film is recognized as a critical component in dry eye disease, this study was designed to determine if single drop either Soothe or Systane produces significant increase thickness (LLT) for subjects reporting symptoms indicative eyes. Methods. A double-blind, internally paired performed. custom-built interferometer, enabling characterization interference patterns, used quantify baseline LLT (OU) eligible subjects. Inclusion criteria included: 1)...
To (1) determine an optimal method of warm compress (WC) application to maximize heating meibomian glands in minimal time, (2) the maximum inner eyelid temperature achievable during 30 min routine WC application, (3) examine cooling curve for 10 after WCs have been discontinued.Subjects were randomly assigned one three methodologies. Group A (GrA), (n = 10): 15 without reheating. GrB, with reheating every 2 min. GrC, 12): optimizing contact lower lid and heated 45 +/- 0.5 degrees C. Outer...
The purpose of this study was to investigate the prevalence lid wiper epitheliopathy (LWE) in patients diagnosed with dry eye disease (DED).Patients were recruited for two groups. Inclusion criteria DED group (n = 50) was: a score greater than 10 Standard Patient Evaluation Eye Dryness questionnaire, fluorescein break-up time 5 seconds or less, corneal and conjunctival staining fluorescein, lissamine green Grade 1 (scale 0-3), Schirmer test anesthesia mm less. For asymptomatic 50), inclusion...
The inner border of the eyelid margin is critically important for ocular surface integrity because it guarantees thin spread tear film. Its exact morphology in human still insufficiently known. histology serial sections upper and lower lid margins whole-mount specimens from 10 body donors was compared to vivo confocal microscopy eight eyes with a Heidelberg retina-tomograph (HRT II) attached Rostock cornea module. Behind posterior Meibomian orifices, cornified epidermis stopped abruptly...
To determine the 1-year post-treatment dry eye status of subjects with meibomian gland dysfunction and symptoms after receiving a single LipiFlow Thermal Pulsation System treatment.Single-centre, prospective, observational, open-label, 1-month-registered clinical trial follow-up examination.Patients evaporative disease who had participated in registered 1-month trial.Eighteen 30 initially enrolled were able to return for follow-up. Both eyes all patients treated 12-min treatment using...
Purpose: The present study examined the long-term (3 years) effects of a single (12 min) thermal pulsation system (TPS) treatment on symptomatic patients with evaporative dry eye disease (DED) secondary to meibomian gland dysfunction (MGD). Methods: In this prospective, cohort, observational, single-center design, signs (meibomian secretion [MGS] scores and tear film breakup time [TBUT]) symptoms (Ocular Surface Disease Index [OSDI] Standard Patient Evaluation Eye Dryness [SPEED]...
To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10 15 µg bimatoprost implant in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). This randomized, 20-month, multicenter, masked, parallel-group, phase 3 trial enrolled 528 OAG OHT an open iridocorneal angle inferiorly study eye. Study eyes were administered on day 1, week 16, 32, twice-daily topical timolol maleate 0.5%. Primary endpoints IOP change from baseline through 12. Safety measures...