A5046374159- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Retinal Diseases and Treatments
- Nerve injury and regeneration
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disorders and Treatments
- Photoreceptor and optogenetics research
- Retinal and Macular Surgery
- Receptor Mechanisms and Signaling
- Retinopathy of Prematurity Studies
- Connexins and lens biology
- Proteoglycans and glycosaminoglycans research
- Cellular transport and secretion
- Regulation of Appetite and Obesity
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Protease and Inhibitor Mechanisms
- Ocular Disorders and Treatments
- RNA regulation and disease
- Axon Guidance and Neuronal Signaling
University of the Basque Country
2016-2025
BioCruces Health research Institute
2017-2024
Departamento de Salud
2017
Basque Government
2017
University of Cambridge
2015
New York Medical College
2015
Ikerbasque
2015
University of North Texas
2010-2013
University of North Texas Health Science Center
2010-2013
Universidad de Salamanca
1989-2011
<i>Purpose:</i> To determine the concentration of interleukins (IL-1β and -6) matrix metalloproteinase 9 (pro-MMP-9) in tears patients with different ocular surface diseases to examine possible relationship between disorders molecular inflammation. <i>Methods:</i> 77 diagnosed as having 18 normal control subjects were studied. Patients routinely examined separated into 5 groups: (1) control, (2) blepharitis, (3) allergic disease, (4) dry eye (5) conjunctivochalasis....
The Josephson transport and the electronic properties of a quantum dot characterized by single level coupled to superconducting leads is analyzed. Different approximations are used compared: mean field approximation, second order perturbation theory in Coulomb interaction exact diagonalization zero band-width limit. system exhibits rich behavior as function relevant parameters. We discuss detail conditions for observation Pi-junction effect interactions on Andreev states.
The health impacts of pulmonary impairment after tuberculosis (TB) treatment have not been included in assessments TB burden. Therefore, previous global and national burden estimates do reflect the full consequences surviving TB. We assessed including Tarrant County, Texas using Disability-adjusted Life Years (DALYs).TB was calculated for all culture-confirmed patients treated at County Public Health between January 2005 December 2006 identical methods life tables as Global Burden Disease...
To evaluate the efficacy of surgical treatment for conjunctivochalasis by monitoring matrix metalloproteinase (MMP)-9 levels in tears patients with before and after surgery their correlation clinical signs symptoms.Twelve eyes symptomatic were included this study as well five healthy volunteers. Ocular surface inflammation was measured terms concentration pro-MMP-9 tears, enzyme-linked immunosorbent assay zymography. Tear analysis performed 1 month surgery. The technique consisted excision...
Abstract Glial cell line‐derived neurotrophic factor (GDNF) enhances the survival of a variety neurons, including photoreceptors (PR) in retina. In contrast to most other GDNF receptive does, however, not exert its neuroprotective activity directly on PR neurons but transmits it indirectly by inducing expression yet unknown factors retinal Müller glial (RMG) cells. Genome‐wide differential transcriptome analyses GDNF‐treated mouse retinas revealed 30 GDNF‐induced transcripts containing total...
Purpose Retinal ganglion cells (RGCs) are exposed to injury in a variety of optic nerve diseases including glaucoma. However, not all respond the same way damage and capacity individual RGCs survive or regenerate is variable. In order elucidate factors that may be important for RGC survival regeneration we have focussed on extracellular matrix (ECM) integrin expression. Our specific questions were: (1) Do adult express particular sets integrins vitro vivo? (2) Can nature ECM influence...
Chemical burns to the eye cause extensive ocular surface damage, often resulting in permanent visual impairment. The amniotic membrane (AM), with its regenerative properties, has shown great potential treating such injuries. Recent innovations, including hydrogel-based delivery systems, have been developed improve drug retention and promote corneal healing. This study aimed evaluate whether hydrogels loaded proteins from human AM could enhance wound healing effectively. Alkaline (8 mm...
In the present work we analyzed distribution of retinal ganglion cells (RGCs) in pig retina. RGCs were retrogradely labeled vivo by injecting Fluoro-Gold into optic nerve. RGC density and terms soma size analyzed. Different regions porcine retina identified following analysis cell size: central retina, found a high-density horizontal band lying dorsal to disc. Moreover, this region, high proportion RCGs with small was observed. From more peripheral observed decrease density, together greater...
Abstract The retinal Müller glial cells, can enhance the survival and activity of neurons, especially ganglion cells (RGCs), which are neurons affected in diseases such as glaucoma, diabetes, ischemia. It has been demonstrated that glia release neurotrophic factors support RGC survival, yet many these remain to be elucidated. To define factors, a quantitative proteomic approach was adopted aiming at identifying neuroprotective proteins. First, conditioned medium from porcine cultured vitro...
Purpose: To compare the protein profiles of tears from normal volunteers and patients with conjunctivochalasis (CCH), a view to identifying proteins whose expression is altered in this pathology. Methods: Tears 8 subjects 6 CCH were analyzed by 2-dimensional electrophoresis. Total was separated first dimension isoelectric focusing, second carried out using 8%-16% sodium dodecyl sulfate-polyacrylamide gel The images Progenesis SameSpot software. Those spots interest manually cut gels,...