A5075802605- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Psoriasis: Treatment and Pathogenesis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Allergic Rhinitis and Sensitization
- Immune Response and Inflammation
- Crime Patterns and Interventions
- Criminal Justice and Corrections Analysis
- IL-33, ST2, and ILC Pathways
- Immunodeficiency and Autoimmune Disorders
- Neonatal Respiratory Health Research
- Pharmacological Effects and Assays
- Policing Practices and Perceptions
- Decision-Making and Behavioral Economics
- Economic and Environmental Valuation
- Phagocytosis and Immune Regulation
- Explainable Artificial Intelligence (XAI)
- Genomics and Rare Diseases
- Body Composition Measurement Techniques
- Disaster Management and Resilience
- Immune Cell Function and Interaction
- Law in Society and Culture
- Eosinophilic Esophagitis
AstraZeneca (Sweden)
2012-2024
University at Albany, State University of New York
2020-2024
Medical University Plovdiv
2017
University of Gothenburg
2005-2010
AstraZeneca (United Kingdom)
2009
The University of Melbourne
2006
National Institute for Health Development
2005
In patients with mild asthma, as-needed use of an inhaled glucocorticoid plus a fast-acting β2-agonist may be alternative to conventional treatment strategies.We conducted 52-week, double-blind trial involving 12 years age or older asthma. Patients were randomly assigned one three regimens: twice-daily placebo terbutaline (0.5 mg) used as needed (terbutaline group), budesonide-formoterol (200 μg budesonide and 6 formoterol) (budesonide-formoterol μg) (budesonide maintenance group). The...
Recent data indicate that the proinflammatory cytokine, interleukin (IL)-17, stimulates certain effector functions of human macrophages. We evaluated whether IL-17 mediates allergen-induced accumulation airway macrophages and, if so, such an effect relates to control macrophage recruitment and survival. BALB/c mice were sensitized challenged with ovalbumin. Three hours before challenge anti-mouse mAb (a-IL-17) was administered. Sampling conducted 24 h after allergen challenge. In vitro...
We administered a survey experiment to national sample of 1068 U.S. adults in April 2020 determine the factors that shape support for various policing tactics midst COVID-19 pandemic. Respondents were sharply divided their views about pandemic and least supportive policies might limit public access officers or reduce crime deterrence. Information health risks officers, but not inmates, significantly increased "precautionary" policing, "social distance" policing. The information effect was...
Cigarette smoke is the major cause of chronic obstructive pulmonary disease (COPD), and there currently no satisfactory therapy to treat people with COPD. We have previously shown that granulocyte/macrophage colony-stimulating factor (GM-CSF) regulates lung innate immunity LPS through Akt/Erk activation nuclear factor-kappaB activator protein (AP)-1.The aim this study was determine whether neutralization GM-CSF can inhibit cigarette smoke-induced inflammation in vivo.Male BALB/c mice were...
This phase 3 trial assessed AZD7442 (tixagevimab/cilgavimab) for post-exposure prophylaxis against symptomatic coronavirus disease 2019 (COVID-19).Adults without prior severe acute respiratory syndrome 2 (SARS-CoV-2) infection or COVID-19 vaccination were enrolled within 8 days of exposure to a SARS-CoV-2-infected individual and randomized 2:1 single 300-mg dose (one 1.5-mL intramuscular injection each tixagevimab cilgavimab) placebo. Primary end points safety first post-dose SARS-CoV-2...
It is known that interleukin (IL)-23, an IL-12-family cytokine, can be released by certain antigen-presenting cells in response to bacterial pathogens. Recent vitro studies indicate this cytokine stimulates a unique subset of CD4 cells, the T helper cell (Th)17 subset, produce and release proinflammatory IL-17. However, it has not been whether action IL-23 per se bearing for early innate lungs vivo there IL-23-responsive population IL-17-producing bronchoalveolar space. We now present...
BackgroundMedication adherence is challenging for adolescents. In mild asthma, as-needed budesonide-formoterol (BUD-FORM) reduces severe exacerbations compared with short-acting beta2-agonists, similar to the reduction maintenance budesonide.ObjectiveThis post hoc pooled analysis of Symbicort Given in Mild Asthma (SYGMA) 1 and 2 assessed efficacy safety BUD-FORM adolescents.MethodsSYGMA were 52-week, double-blind studies (NCT022149199; NCT02224157) patients 12 years or older asthma. Patients...
In many patients with mild asthma, the low frequency of symptoms and episodic nature exacerbations make adherence to regular maintenance treatment difficult. This often leads over-reliance on short-acting β2-agonist (SABA) reliever medication under-treatment underlying inflammation, poor control asthma increased risk exacerbations. The use budesonide/formoterol 'as needed' in response may represent an alternative option for asthma.The SYmbicort Given as needed Mild Asthma (SYGMA) programme...
To evaluate the efficacy and tolerability of budesonide/formoterol as maintenance reliever therapy versus plus terbutaline in adults with persistent asthma not adequately controlled inhaled corticosteroid (ICS) alone.In this 12-month, randomized, double-blind, parallel-group, phase III study (NCT00839800), patients (age ≥ 16 years; receiving ICS; 1 severe exacerbation 12 months prior to entry) were randomized either 160/4.5 μg inhalation twice daily as-needed or 0.4 mg for months.time first...
In mice, the cytokine interleukin (IL)-17A causes a local accumulation of neutrophils within bronchoalveolar space. IL-17A may thereby also contribute to an increased proteolytic burden. current study, we determined whether mRNA for is elevated and protein expression occurs locally in inflammatory cells human space during severe inflammation caused by organic dust. We assessed elastinolytic protease MMP-9 this airway compartment.Six healthy, non-smoking volunteers were exposed dust swine...
To evaluate the efficacy and safety of AZD1981, a potent, specific antagonist CRTh2 receptor, as add-on therapy to inhaled corticosteroids (ICS) long-acting β2-agonists (LABA), in patients with persistent asthma an allergic component.In this placebo-controlled, parallel-group Phase IIb study, atopic on ICS LABA were randomized receive 12 weeks treatment placebo or AZD1981 (80 mg daily, 200 10 mg, 40 100 400 twice daily [BID]). The primary end point was mean change from baseline predose,...
Coronavirus disease 2019 (COVID-19) has presented the American criminal justice system with unprecedented challenges, including protecting safety of incarcerated men and women. Given ill-suited structure correctional facilities to facilitate health guidelines, one solution is decarceration. Yet decarceration faced political public backlash. As no evidence currently exists on how views this emergency solution, authors examined correlates support for by conducting a survey experiment in which...
Budesonide-formoterol taken as needed is an emerging treatment for mild asthma. We used data from the SYGMA studies to assess safety of As-needed budesonide-formoterol compared with terbutaline and maintenance budesonide. 1 2 were 52-week, double-blind, parallel-group in patients aged ≥ 12 years physician-assessed Patients randomized 200/6 μg, twice-daily budesonide 200 μg plus 0.5 mg, mg (SYGMA only). Adverse events (AEs), serious AEs (SAEs), discontinuations due (DAEs), study-defined...
Naive CD4 cells are capable of integrating signals from antigen-activated the innate immune system and differentiating into effector cells, also termed T helper (Th) cells. According to traditional paradigm explaining adaptive cell responses, there two subsets Th cells: Th-1 Th-2 subset. Each these undergoes a distinct differentiation pathway (a that is characterized by unique profile cytokine production has specific immunoregulatory functions). However, recent studies in mouse models have...
The aim of this study was to assess the attitudes and opinions on potential use whole-genome sequencing (WGS) in conjunction with traditional newborn screening (NBS). We conducted an online survey among pediatricians geneticists from Bulgaria. based concept non-selective WGS for all newborns analysis genes.In total, 120 out 299 invited participants completed survey, overall response rate 40.1%. While half surveyed supported population-based NBS, 65.2% expressed concerns. Most underlined that...
It is uncertain whether phenotypes of asthma and chronic obstructive pulmonary disease (COPD) vary between populations with different genetic environmental characteristics. Here, our objective was to compare the airways in two separate populations. This a cross-sectional observational study adult from New Zealand China. Participants aged 40–75 years who reported wheeze breathlessness last 12 months were randomly selected general population underwent detailed characterisation. Complete data...
Background: Functional respiratory imaging (FRI) is a quantitative postprocessing technique used to assess changes in the system. Using FRI, we characterized effects of long-acting muscarinic antagonist (LAMA), glycopyrrolate metered dose inhaler (GP MDI), and β 2 -agonist (LABA), formoterol fumarate (FF on airway volume resistance patients with moderate-to-severe chronic obstructive pulmonary disease. Methods: Patients this phase IIIb, randomized, double-blind crossover study received...