A5100722330- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- COVID-19 Clinical Research Studies
- Lung Cancer Research Studies
- SARS-CoV-2 and COVID-19 Research
- Economic and Financial Impacts of Cancer
- Genetic factors in colorectal cancer
- Breast Cancer Treatment Studies
- SARS-CoV-2 detection and testing
- Cancer Genomics and Diagnostics
- Medical Imaging Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Radiation Detection and Scintillator Technologies
- Chronic Myeloid Leukemia Treatments
- Cancer-related Molecular Pathways
- Cancer Risks and Factors
- Prostate Cancer Treatment and Research
- Nutrition, Genetics, and Disease
- Lymphoma Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Infrared Thermography in Medicine
Bristol-Myers Squibb (United Kingdom)
2022-2025
Bristol-Myers Squibb (United States)
2024
Bristol-Myers Squibb (Italy)
2023
University of Nottingham
2023
ICF International (United States)
2020-2022
Institute of Electrical and Electronics Engineers
2020-2021
Food and Nutrition Service
2020
Novartis (United Kingdom)
2019-2020
IEEE Computer Society
2020
Regional Municipality of Niagara
2020
Case-based surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection likely underestimates the true prevalence infections. Large-scale seroprevalence surveys can better estimate across many geographic regions.To persons with SARS-CoV-2 antibodies using residual sera from commercial laboratories US and assess changes over time.This repeated, cross-sectional study conducted all 50 states, District Columbia, Puerto Rico used a convenience sample serum specimens...
In December 2021, the B.1.1.529 (Omicron) variant of SARS-CoV-2, virus that causes COVID-19, became predominant in United States. Subsequently, national COVID-19 case rates peaked at their highest recorded levels.* Traditional methods disease surveillance do not capture all cases because some are asymptomatic, diagnosed, or reported; therefore, proportion population with SARS-CoV-2 antibodies (i.e., seroprevalence) can improve understanding population-level incidence COVID-19. This report...
Background In CheckMate 9LA, nivolumab plus ipilimumab with chemotherapy prolonged overall survival (OS) versus regardless of tumor PD-L1 expression or histology. We report updated efficacy and safety in all randomized patients a minimum 4-year follow-up an exploratory treatment-switching adjustment analysis treated who received subsequent immunotherapy. Methods Adults stage IV/recurrent non-small cell lung cancer (NSCLC), no sensitizing EGFR/ALK alterations, ECOG performance status ≤1 were...
Sero-surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can reveal trends and differences in subgroups capture undetected or unreported infections that are not included case-based surveillance systems. Cross-sectional, convenience samples remnant sera from clinical laboratories 51 U.S. jurisdictions were assayed for infection-induced SARS-CoV-2 antibodies biweekly October 25, 2020, to July 11, 2021, monthly September 6, February 26, 2022. Test results analyzed...
Abstract Background The landscape of non-small cell lung cancer (NSCLC) therapy is rapidly changing. This analysis aimed to understand patient characteristics, diagnosis and treatment patterns in patients with metastatic NSCLC (mNSCLC) without EGFR ALK mutations across five European countries. Methods Data were drawn from the Adelphi Disease Specific Programme™, a point-in-time survey oncologists/pulmonologists their consulting France, Germany, Italy, Spain UK. Physicians completed record...
This study describes treatment and retreatment patterns outcomes in patients France following nivolumab as a second-line or later (2L+) locally advanced metastatic non-small cell lung cancer (LAM NSCLC). analysis included adults with tumor, node, metastasis stage IIIB-IV NSCLC (as defined the 7th 8th edition American Joint Committee on Cancer/Union for International Cancer Control) treated monotherapy 2L+ using data from retrospective Epidemiological-Strategy Medical Economics Lung database....
Head-to-head evidence comparing repotrectinib against other approved ROS1 tyrosine kinase inhibitors (TKIs) is not currently available. The objective of this study was to indirectly compare progression-free survival (PFS), the response rate (ORR), and duration (DoR) for vs. crizotinib entrectinib in patients with TKI-naïve ROS1+ locally advanced or metastatic non-small-cell lung cancer (aNSCLC). Using from a systematic literature review, unanchored matching-adjusted indirect comparisons...
Treatment with abiraterone acetate and prednisone (AA/P) prolongs survival in metastatic castration-resistant prostate cancer (mCRPC) patients. We evaluated the genetic variation CYP17A1 as predictive of response to AA/P. A prospective collection germline DNA prior AA/P initiation follow-up a mCRPC cohort was performed. Five common single-nucleotide polymorphisms (SNPs) identified using haplotype-based tagging algorithm were genotyped. Clinical outcomes included biochemical time progression...
Objective: To evaluate the cost-effectiveness of ribociclib plus letrozole versus palbociclib in post-menopausal women with hormone receptor positive (HR+) and human epidermal growth 2 negative (HER2-) advanced breast cancer from a UK payer perspective. Methods: A cohort-based partitioned survival model was developed to HR+/HER2- over lifetime horizon. The analysis carried out National Health Services Personal Social perspective, results are presented incremental costs per quality adjusted...
Introduction Rotavirus A is a major cause of acute dehydrating diarrhea in neonatal pigs resulting significant mortality, morbidity, reduced performance and economic loss. Commercially available prebiotic galacto-oligosaccharides are similar to those mammalian milk stimulate the development microbiota immune system neonates. Little known about effects supplementing sows' diets with during gestation. This study aimed determine if dietary galacto-oligosaccharide supplementation gestation could...
Abstract Background Study aimed to characterise treatment and outcomes for patients with hormone receptor positive (HR+), human epidermal growth factor 2 negative (HER2-) metastatic breast cancer (MBC) within a large regional centre, as benchmark evaluating real-world impact of novel therapies. Methods Retrospective longitudinal cohort, using electronic patient records adult females first diagnosis HR+/HER2- MBC January 2012–March 2018. Results One hundred ninety-six women were identified...
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This economic analysis evaluated the cost-effectiveness of nivolumab (NIVO) plus ipilimumab (IPI) two cycles platinum-doublet chemotherapy (PDC) compared with four PDC as first-line treatment for patients advanced NSCLC in United States (US).A partitioned survival model was constructed three mutually exclusive health states: progression free, progressed disease, and death. The conducted from a US healthcare payer perspective, using time horizon 25 years. Costs outcomes were discounted at 3%...
3510 Background: Prediction of 5-FU-related adverse events (5FU-AEs) continues to be problematic. Pharmacogenetic studies on the rate-limiting enzyme in 5-FU metabolism, dihydropyrimidine dehydrogenase (DPD), suggest a link between three variants and both decreased activity increased toxicity: c.1905+1 G>A (DPYD*2A; rs3918290), c.1679 T>G (I560S; DPYD*13; rs55886062), c.2846A>T (D949V; rs67376798). Since impact DPYD toxicity remains controversial, we determined associations known...
Objectives The Medical Monitoring Project (MMP) is a public health surveillance system that provides representative estimates of the experiences and behaviors adults with diagnosed HIV in United States. In 2015, sample design frame MMP changed from only included patients to one captures persons receiving not care. We describe methods investigated for calculating survey weights, approach chosen, benefits using dynamic registry as sampling frame. Methods samples National Surveillance System,...
We present the design, manufacture, and test results of an asynchronous event-driven address time-stamped (EDATS) pixelated array detector, operational over correlation time spans ranging from less than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> to greater xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> s. The EDATS detector was designed measure equilibrium density fluctuations on a nanometer-length scale using small angle...
We evaluated the cost-effectiveness of nivolumab in combination with ipilimumab (NIVO + IPI) versus platinum-doublet chemotherapy (PDC) for first-line treatment stage IV or recurrent non-small cell lung cancer (NSCLC) from a third-party payer perspective United States (US).A partitioned survival model was developed using efficacy, safety, and utility inputs derived Part 1 phase 3 CheckMate 227 trial (NCT02477826) 37.7-month minimum follow-up overall (OS). OS progression-free (PF) were...
This study assessed the cost-effectiveness of nivolumab plus ipilimumab (NIVO+IPI) versus platinum-doublet chemotherapy (chemo) in untreated metastatic non-small cell lung cancer (NSCLC) using mixture-cure modelling, an approach used to analyse immuno-oncology treatments due their underlying methods depicting delayed but durable response some patients. A economic model was developed from a US third-party payer perspective assess lifetime costs and benefits NIVO+IPI chemo data Part 1 phase...