A5041750449- Healthcare Policy and Management
- Primary Care and Health Outcomes
- Advanced Causal Inference Techniques
- Statistical Methods and Inference
- Health Systems, Economic Evaluations, Quality of Life
- Patient Satisfaction in Healthcare
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- Single-cell and spatial transcriptomics
- Opioid Use Disorder Treatment
- Geriatric Care and Nursing Homes
- Statistical Methods and Bayesian Inference
- Healthcare cost, quality, practices
- Racial and Ethnic Identity Research
- Bayesian Methods and Mixture Models
- Statistical Methods in Clinical Trials
- Adolescent Sexual and Reproductive Health
- HIV/AIDS Research and Interventions
- Cancer-related molecular mechanisms research
- Substance Abuse Treatment and Outcomes
- Prenatal Substance Exposure Effects
- Emergency and Acute Care Studies
- Healthcare Systems and Reforms
- Genetic Associations and Epidemiology
- Distributed Sensor Networks and Detection Algorithms
RAND Corporation
2016-2025
Blue Dot Solutions (Poland)
2025
National Bureau of Economic Research
2023
George Mason University
2023
Indiana University Bloomington
2023
Harvard University
2015-2022
Aetna (United States)
2017-2020
Brigham and Women's Hospital
2020
University of North Carolina at Chapel Hill
2020
Hadassah Medical Center
2020
To quantify the effects of varying opioid prescribing patterns after surgery on dependence, overdose, or abuse in an naive population.Retrospective cohort study.Surgical claims from a linked medical and pharmacy administrative database 37 651 619 commercially insured patients between 2008 2016.1 015 116 undergoing surgery.Use oral opioids discharge as defined by refills total dosage duration use. The primary outcome was composite misuse identified diagnostic code for abuse, overdose.568 612...
<h3>Abstract</h3> <h3>Objective</h3> To evaluate on a large scale, across 272 common types of laboratory tests, the impact healthcare processes predictive value electronic health record (EHR) data. <h3>Design</h3> Retrospective observational study. <h3>Setting</h3> Two hospitals in Boston, Massachusetts, with inpatient, emergency, and ambulatory care. <h3>Participants</h3> All 669 452 patients treated at two over one year between 2005 2006. <h3>Main outcome measures</h3> The relative...
Abstract The growth in healthcare spending is an important topic the United States, and preterm low-birthweight infants have some of highest expenditures any patient population. We performed a retrospective cohort study this population using large, national claims database commercially insured individuals. A total 763,566 with insurance coverage through Aetna, Inc. for first 6 months post-natal life were included, received approximately $8.4 billion (2016 USD) services. Infants billing codes...
<h3>Importance</h3> Following reductions in US ambulatory care early the pandemic, it remains unclear whether consistently returned to expected rates across insurance types and services. <h3>Objective</h3> To assess patients with Medicaid or Medicare-Medicaid dual eligibility had significantly lower than return use of commercial, Medicare Advantage, fee-for-service insurance. <h3>Design, Setting, Participants</h3> In this retrospective cohort study examining service patterns from January 1,...
Background Typically, algorithms to classify phenotypes using electronic medical record (EMR) data were developed perform well in a specific patient population. There is increasing interest analyses which can allow study of outcome across different diseases. Such the EMR would require an algorithm that be applied populations. Our objectives were: (1) develop enable coronary artery disease (CAD) diverse populations; (2) impact adding narrative extracted natural language processing (NLP)...
<h3>Importance</h3> Low-value care, defined as care offering no net benefit in specific clinical scenarios, is associated with harmful outcomes patients and wasteful spending. Despite a national education campaign increasing attention on reducing health waste, recent trends low-value delivery remain unknown. <h3>Objective</h3> To assess use <h3>Design, Setting, Participants</h3> In this cross-sectional study, analyses of spending from 2014 to 2018 were conducted using 100% Medicare...
Vitamin D deficiency is of increasing concern in HIV-infected persons because its reported association with a number negative health outcomes that are common HIV. We undertook this study to determine the prevalence and predictors vitamin among nationally representative cohort middle-aged, ethnically diverse, HIV-uninfected women enrolled Women's Interagency HIV Study (WIHS).Vitamin testing was performed by Quest Diagnostics on frozen sera using liquid chromatography/mass spectroscopy method....
Autism spectrum disorder (ASD) is known to be more prevalent among males than females in the general population. Although overall risk of recurrence ASD siblings has been estimated between 6.1% and 24.7%, information on sex-specific patterns lacking.To estimate high-confidence rates siblings.This observational study used an administrative database measure incidence children 1 583 271 families (37 507 with at least diagnosis ASD) enrolled commercial health care insurance plans a large US...
Objective We investigated the presence of non-neuromuscular phenotypes in patients affected by Spinal Muscular Atrophy (SMA), a disorder caused mutation Survival Motor Neuron (SMN) gene, and whether these may be clinically detectable prior to clinical signs neuromuscular degeneration therefore independent muscle weakness. Methods utilized de-identified database insurance claims explore health 1,038 SMA compared controls. Two analyses were performed: (1) from entire coverage window; (2) for...
Microbial translocation has been implicated in the pathogenesis of liver fibrosis and cirrhosis. We sought to determine whether markers microbial are associated with disease progression during coinfection human immunodeficiency virus (HIV) hepatitis C (HCV).We measured serial plasma lipopolysaccharide (LPS), endotoxin core antibody, intestinal fatty acid-binding protein (I-FABP), soluble CD14 (sCD14), interleukin 6 (IL-6), 10, tumor necrosis factor α (TNF-α) levels over a 5-year period 44...
BackgroundA considerable number of Gram-negative bacteraemias occur outside intensive care units (ICUs). Inadequate antibiotic therapy in ICUs has been associated with adverse outcomes; however, there are no prospective studies non-ICU patients.
Summary Valid estimation of treatment effects from observational data requires proper control confounding. If the number covariates is large relative to observations, then controlling for all available infeasible. In cases where a sparsity condition holds, variable selection or penalization can reduce dimension covariate space in manner that allows valid effects. this article, we propose matching on both estimated propensity score and prognostic scores when observations. We derive asymptotic...
To describe differences in patient experiences of hospital care by preferred language within racial/ethnic groups.2014-2015 HCAHPS survey data.We compared six composite measures for seven languages (English, Spanish, Russian, Portuguese, Chinese, Vietnamese, and Other) applicable subsets five groups (Hispanics, Asian/Pacific Islanders, American Indian/Alaska Natives, Blacks, Whites). We measured patient-mix adjusted overall, between- within-hospital experience language, using linear...
American Indian and Alaska Native (AI/AN) youth exhibit multiple health disparities, including high rates of alcohol other drug (AOD) use, violence delinquency, mental problems. Approximately 70% AI/AN reside in urban areas, where negative outcomes on behavioral well-being are often high. Identity development may be particularly complex settings, face more fragmented lower density communities, as well mixed racial-ethnic ancestry decreased familiarity with lifeways. This study examines...
Objectives: There are limited public health data on urban American Indian/Alaska Native (AI/AN) populations, particularly adolescents. The current study attempted to address gaps by providing descriptive information experiences of AI/AN adolescents across northern, central, and southern California.Design: We describe demographics several behavioral cultural domains, including: alcohol other drug (AOD) use, risky sexual behavior, mental physical health, discrimination experiences, involvement...
This study explores trends in buprenorphine availability at substance use disorder treatment facilities (SUDTFs) and by waivered clinicians during the pandemic. We also examined whether there were differences access based on a county's metropolitan status annual fatal drug poisoning rate.
Rates of opioid use disorder (OUD) have increased in older adults (age ≥ 50). Medications for OUD (MOUD) treat effectively; however, limited data exist on whether with are provided MOUD. Using 2016-2020 claims from Medicare beneficiaries a new episode OUD, we calculated rates MOUD initiation (first dispensing within 14 days index event), engagement (dispensing second 34 initiation), and retention (receiving consistently over 180 days). Among qualifying events (N = 40 336), 17%, 38%, 45% were...
To combat the ongoing opioid crisis, policy makers and public health officials are developing novel policies to increase availability of medications for use disorder (OUD). An important question is what extent geographic treatment programs (OTPs) associated with receipt. Understanding this association may help additional medication OUD dispensing improve population outcomes. quantify trends in methadone Medicare beneficiaries based on proximity an OTP. This cross-sectional study analyzed...
Objectives To investigate whether health care experiences of adult Medicaid beneficiaries differ by race/ethnicity and rural/urban status. Data Sources A total 270 243 respondents to the 2014‐2015 Nationwide Adult Consumer Assessment Healthcare Providers Systems Survey. Study Design Linear regression was used estimate case mix adjusted differences in patient experience between racial/ethnic minority non‐Hispanic white beneficiaries, residing small urban areas, towns, rural areas vs large...
Importance COVID-19 pandemic-related disruptions to the health care system may have resulted in increased mortality for patients with time-sensitive conditions. Objective To examine whether in-hospital hospitalizations not related (non–COVID-19 stays) conditions changed during pandemic and how it varied by hospital urban vs rural location. Design, Setting, Participants This cohort study was an interrupted time-series analysis assess (March 8, 2020, December 31, 2021) compared prepandemic...
Abstract RNA-seq studies are growing in size and popularity. We provide evidence that the most commonly used methods for differential expression analysis (DEA) may yield too many false positive results some situations. present dearseq, a new method DEA controls discovery rate (FDR) without making any assumption about true distribution of data. show dearseq FDR while maintaining strong statistical power compared to popular methods. demonstrate this behavior with mathematical proofs,...