A5007955935- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Prenatal Screening and Diagnostics
- Child and Adolescent Health
- Neonatal Health and Biochemistry
- Blood groups and transfusion
- Metabolism and Genetic Disorders
- Tuberculosis Research and Epidemiology
- COVID-19 and healthcare impacts
- Clinical practice guidelines implementation
- Telemedicine and Telehealth Implementation
- Cervical Cancer and HPV Research
- Romani and Gypsy Studies
- Global Cancer Incidence and Screening
- Public Health Policies and Education
- Global Maternal and Child Health
- Health Promotion and Cardiovascular Prevention
- Emergency and Acute Care Studies
- Autopsy Techniques and Outcomes
- COVID-19 and Mental Health
- Pneumonia and Respiratory Infections
- Genomics and Rare Diseases
- HIV/AIDS Research and Interventions
- Health and Conflict Studies
- Homelessness and Social Issues
Public Health England
2017-2021
King's College London
2008-2021
St. Thomas Hospital
1996-2015
University of Cambridge
1980-2013
King's College Hospital
1993-2004
University of Leeds
2004
National Health Laboratory Service
2004
University of the Witwatersrand
2004
St Thomas' Hospital
1993-1998
Multiple Sclerosis Society
1998
Backgroundthe aim of this review was to analyze the implementation and impact remote home monitoring models (virtual wards) for confirmed or suspected COVID-19 patients, identifying their main components, processes implementation, target patient populations, on outcomes, costs lessons learnt.Methodswe carried out a rapid systematic led by primary secondary care across seven countries (US, Australia, Canada, The Netherlands, Ireland, China, UK). outcomes included in were: virtual length stay,...
Antenatal screening/testing of pregnant women should be carried out according to the guidelines NHS Sickle Cell and Thalassaemia Screening programme. Newborn screening and, when necessary, follow up testing referral, All babies under 1 year age arriving in UK offered for sickle cell disease. Preoperative disease patients from ethnic groups which there is a significant prevalence condition. Emergency with solubility tests must always followed by definitive analysis. Laboratories performing...
Sickle Cell Disease (SCD) is an increasing global health problem and presents significant challenges to European care systems. Newborn screening (NBS) for SCD enables early initiation of preventive measures has contributed a reduction in childhood mortality from SCD. Policies methodologies NBS vary different countries, this might have consequences the quality clinical outcomes across Europe. A two-day Pan-European consensus conference was held Berlin April 2017 order appraise current status...
To investigate how sociocultural factors influence the management of pain from sickle cell disease by comparing experiences those who usually manage their at home with are more frequently admitted to hospital for pain.Qualitative analysis semistructured individual interviews and focus group discussions.57 participants genotype SS or S/beta-thal (44 participants) SC (9 participants); status 4 was unknown. 40 took part in groups, 6 both groups interviews, 9 were interviewed only. Participants...
<h3>Objective</h3> To evaluate England's NHS newborn sickle cell screening programme performance in children up to the age of 5 years. <h3>Design</h3> Cohort resident infants with disease (SCD) born between 1 September 2010 and 31 August 2015 followed until 2016. <h3>Participants</h3> 1317 SCD were notified study from all centres England 1313 (99%) up. <h3>Interventions</h3> Early enrolment clinical follow-up, parental education routine penicillin prophylaxis. <h3>Main outcome measures</h3>...
Early results from the National Health Service Sickle Cell and Thalassaemia Screening programme covering whole of England are reported following implementation national newborn blood-spot screening programme. Of 13 laboratories performing screening, 10 chose high-performance liquid chromatography as first screen, with isoelectric focusing second confirmatory test. for April 2005 to March 2007 presented include data all newborns in England, almost 1.2 million infants. The screen-positive show...
Sickle cell disease (SCD) is a recognized cause of childhood mortality. Tanzania has the fifth highest incidence SCD (with an estimated 11 000 annual births) worldwide. Although newborn screening (NBS) for and comprehensive healthcare have been shown to reduce under-5 mortality by up 94% in high-income countries such as USA, no country Africa maintained NBS national health program. The aims this program were establish evaluate NBS-SCD intervention determine birth prevalence SCD.Muhimbili...
Aims The overall aim of the new national newborn programme is to identify infants at risk sickle cell disease allow early detection and minimise deaths complications. Methods Universal screening for was introduced in England between September 2003 July 2006. 13 laboratories each screen 25 000 110 babies a year using existing dried bloodspot cards. specified conditions be screened include anaemia (Hb SS), Hb SC disease, S/ β thalassaemia, S/D Punjab S/O Arab . Data are reported on results by...
Objectives This paper reports early screening results from the newborn sickle cell disease programme recently implemented in England. Setting Screening is offered at 5-8 days of age as part existing bloodspot test and to all babies irrespective ethnicity. Methods The laboratory methods recommended are high performance liquid chromatography (HPLC) iso-electric focusing (IEF). 15 Two analysis must be applied screen positive results. conditions screened for are:- Sickle anaemia (Hb SS), Hb SC...
Skin cancer has been identified as a key area in the English health strategy. Review of trends epidemiology melanoma by age, sex and social class can contribute to ensuring that preventive efforts are targeted appropriately subsequently monitoring effects campaigns.Descriptive epidemiological study using data for both sexes from registrations age (England & Wales 1971-1989), mortality statistics 1951-1970, England 1969-1992) 1970-1972 men women, 1979-1980, 1982-1983 Great Britain women)....
<h3>Objective</h3> To describe the clinical presentation, risk factors, serotype distribution and outcomes of invasive pneumococcal disease (IPD) in children with sickle cell (SCD) following introduction 13-valent conjugate vaccine (PCV13) UK. <h3>Design</h3> Prospective national newborn screening for SCD enhanced IPD surveillance. <h3>Participants</h3> Children born England between 1 September 2010 31 August 2014 who developed laboratory-confirmed by December 2015. <h3>Main measures</h3>...
The national neonatal screening programme for phenylketonuria was established in 1969, with congenital hypothyroidism being added 1981. aim of the is to reduce morbidity by complete and timely detection treatment affected cases. Scientific developments mean that many other disorders can be screened for.1 extent United Kingdom uncertain not all proposed programmes meet, or have been formally assessed against, criteria suitability.2 Also, loss regional responsibility overview may result...
There are limited published data on the performance of percentage haemoglobin A (Hb A) as a screening test for beta thalassaemia major in newborn period. This paper aims to analyse derived from national bloodspot programme sickle cell disease period.Newborn 2,288,008 babies were analysed. Data reported NHS Sickle Cell and Thalassaemia Screening Programme England period 2005 2012 also reviewed identify any missed cases (4,599,849 babies).Within cohort births, 170 identified screen positive...
<h3>Abstract</h3> <b>Objectives</b> : To determine whether coverage of the neonatal (Guthrie) screening programme in Britain is different for groups at highest risk sickle cell disease and to identify possible reasons incomplete coverage. <b>Design</b> Descriptive study its variation by mobility, district residence, ethnic group. Subjects - 1727 infants born between 1 October 31 December 1991. Setting-Former West Lambeth Camberwell District Health Authorities, London. <b>Main outcome...
A new report on the needs of Londoners with Sickle Cell Disease. The emphasises that sickle cell disorders are no longer a rare 'exotic' condition in this country but relatively common health problem and reason for admission to hospital inner city areas London.