A5024542760- Complement system in diseases
- SARS-CoV-2 and COVID-19 Research
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- Blood groups and transfusion
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Iron Metabolism and Disorders
- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- Neutropenia and Cancer Infections
- Long-Term Effects of COVID-19
- Platelet Disorders and Treatments
- Lipoproteins and Cardiovascular Health
- Acute Lymphoblastic Leukemia research
- Immune responses and vaccinations
- Renal Diseases and Glomerulopathies
- Transgenic Plants and Applications
- T-cell and B-cell Immunology
- Peripheral Neuropathies and Disorders
- Diabetic Foot Ulcer Assessment and Management
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
INCLIVA Health Research Institute
2018-2025
Hospital Clínico Universitario de Valencia
2005-2023
Universitat de València
2005-2018
Canadian Apheresis Group
2018
Abstract Immune thrombotic thrombocytopenic purpura (iTTP) is a microangiopathy caused by anti-ADAMTS13 antibodies. Caplacizumab approved for adults with an acute episode of iTTP in conjunction plasma exchange (PEX) and immunosuppression. The objective this study was to analyze compare the safety efficacy caplacizumab vs standard care assess effect concomitant use rituximab. A retrospective from Spanish TTP Registry patients treated those who did not receive it conducted. total 155 (77...
Immune effector cell-associated neurotoxicity syndrome (ICANS) is common after chimeric antigen receptor T-cell (CAR-T) therapy. Objective. This study aimed to assess the impact of preinfusion electroencephalography (EEG) abnormalities and EEG findings at ICANS onset for predicting risk severity in 56 adult patients with refractory lymphoma undergoing CAR-T Study design. EEGs were conducted time lymphodepleting chemotherapy shortly ICANS. Results. Twenty-eight (50%) developed a median 6 days...
ABSTRACT Introduction Current guidelines do not mandate CD19 tumor expression assessment before chimeric antigen receptor T‐cell (CAR‐T) therapy in large B‐cell lymphoma (LBCL) patients due to limitations of immunohistochemistry (IHC) or flow cytometry. Quantitative polymerase chain reaction (qPCR) offers a more sensitive alternative for detecting expression, with the primary advantage that mRNA can be easily extracted from paraffin‐embedded tissues. Methods & Results In our study, we...
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare disease characterized by the presence of anti-ADAMTS13 autoantibodies. Achieving accurate information on incidence and customary management important to provide appropriate diagnostic therapeutic resources. The aim this study was determine outcomes iTTP in Spain.A cross-sectional survey carried out among Spanish hospitals, focused patients ≥16 years old attended between 2015 2017, those at follow-up before that interval....
Abstract: The association between cytomegalovirus (CMV) infection and the development of Guillain–Barré syndrome (GBS) in setting allogeneic hematopoietic stem cell transplantation (alloSCT) has been reported only occasionally. We describe here a 23‐year‐old patient diagnosed with acute myelogenous leukemia who underwent partially HLA‐mismatched alloSCT soon after developed GBS along CMV infection. Serum autoantibodies to several ganglioside antigens were concomitantly detected. Despite...
Abstract We conducted a multicenter interventional study to assess the efficacy of Therakos ECP treat steroid‐resistant graft‐vs‐host disease (SRes‐GVHD) after allogeneic HSCT and identify biomarkers GVHD response. A total 62 patients were treated for acute SRes‐GVHD (n = 37) or chronic 25). Median time best response was 35 days (range, 28‐85) 90 27‐240) in SRes‐GVHD, respectively. Overall, 27 (72.9%) with SRes‐aGVHD responded treatment (40.5% CR 32.4% PR). The rate significantly higher...
Homozygous familial hypercholesterolaemia (HoFH) is a rare, genetic disorder of abnormally high levels low-density lipoprotein cholesterol (LDL-C) requiring aggressive interventions to retard the evolution atherosclerotic cardiovascular disease. We treated two brothers (ages 46 years and 47 years) with HoFH statins, lipoproteinapheresis (LA) microsomal triglyceride transfer protein inhibitor lomitapide. Both carried p.Thr434Arg homozygous <i>LDLR</i> mutation had childhood total >700...
High-dose chemotherapy supported by autologous stem cell transplant (ASCT) remains the treatment of choice for patients with lymphoma failing first-line chemotherapy. Recent evidence suggests a relationship between genetic variations in genes involved DNA repair and outcome number malignancies. In this work, we retrospectively evaluated influence an XRCC1 polymorphism (rs25487) on results series 73 subjected to ASCT. The factors correlated overall survival were disease status at genotype....
Topic: 19. Aggressive Non-Hodgkin lymphoma - Clinical Background: Chimeric antigen receptor T-cell (CAR-T) therapy has improved outcomes in relapsed/refractory patients with haematological malignancies. Hematotoxicity, including neutropenia, anaemia, and thrombocytopenia, is frequent after CAR-T therapy. Aims: To assess risk factors, incidence evolution of cytopenias following Methods: A retrospective, single institution analysis was conducted on adult who received commercial [tisa-cel or...
In this report, we describe a case of somatic mutations in the two HLA‐B genes patient with acute myelogenous leukemia. The HLA‐B*15:01 allele showed an insertion nucleotides within exon 2 leading to premature stop codon. HLA‐B*40:01 one nucleotide substitution 3, identical that described for B*15:258N . restriction these leukemic cells was confirmed patient's samples from buccal epithelial and hematopoietic obtained when remission. clinical significance HLA cancer seems be associated escape...