A5025490397- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Mesenchymal stem cell research
- Cardiac pacing and defibrillation studies
- Bone fractures and treatments
- Heart Failure Treatment and Management
- Combustion and Detonation Processes
- Congenital Heart Disease Studies
- Risk and Safety Analysis
- TGF-β signaling in diseases
- Cardiac Valve Diseases and Treatments
- Grouting, Rheology, and Soil Mechanics
- Osteoarthritis Treatment and Mechanisms
- Cell Adhesion Molecules Research
- Fire dynamics and safety research
- Optical Coherence Tomography Applications
- Fuel Cells and Related Materials
- Transplantation: Methods and Outcomes
- Tunneling and Rock Mechanics
- Bone Tissue Engineering Materials
- Optical Imaging and Spectroscopy Techniques
- Tissue Engineering and Regenerative Medicine
- Aortic Disease and Treatment Approaches
- Chemokine receptors and signaling
Lawrence Berkeley National Laboratory
2000-2023
University of California, Riverside
2017-2020
National Cancer Institute
2019
University of North Carolina at Chapel Hill
2003-2016
Exponent (United States)
2003-2016
University of North Carolina Health Care
2016
Scientific Consulting Group
2012
University of Louisville
2010
St. Luke's Episcopal Hospital
2000-2009
UNC Lineberger Comprehensive Cancer Center
2009
Abstract Mesenchymal stem cells (MSC) have a therapeutic potential in patients with fractures to reduce the time of healing and treat nonunions. The use MSC is attractive for several reasons. First, MSCs would be implementing conventional reparative process that seems defective or protracted. Secondly, effects treatment needed only relatively brief duration reparation. However, an integrated approach define multiple regenerative contributions fracture repair necessary before clinical trials...
The purpose of this investigation was to evaluate the efficacy and safety implanting expandable intravascular stents in pulmonary arteries systemic veins. Twenty-seven balloon-expandable grafts were placed 13 mongrel dogs under anesthesia. A long sheath introduced over a wire catheter or dilator into artery target vein. collapsed stainless steel mesh stent balloon an angioplasty catheter. with mounted advanced through sheath. expanded diameter as inflated, remained deflated. further larger...
Implantable left ventricular assist systems (LVASs) are used for bridging to transplantation, myocardial improvement, and permanent circulatory support. Conventional implantable have inherent limitations that increase morbidity during In contrast, small, efficient, axial-flow pumps, which been under development the past decade, potential improve length quality of life in patients with severe heart failure. Methods Results- To assess safety clinical utility Jarvik 2000, we implanted this...
Failures of fracture repair (nonunions) occur in 10% all fractures. The use mesenchymal stem cells (MSC) tissue regeneration appears to be rationale, safe, and feasible. contributions MSC the reparative process can through autocrine paracrine effects. primary objective this study is find a novel mean, by transplanting cultures bone marrow-derived MSCs expressing insulin-like growth factor-I (MSC(IGF)), promote these seed-and-soil actions fully implement their regenerative abilities...
The population-balance framework of Kovscek, Patzek, and Radke is extended to model the flow foam in porous media containing residual oil (Kovscek et al. Chem. Eng. Sci. 1995, 50, 3783). A mechanistic rate coalescence due oil, based on recently proposed pinch-off mechanism (Myers, T. J. Ph.D. Dissertation, University California, Berkeley, CA), included model. New foam-flow experiments absence presence 1.1- 0.28-μm2 Berea sandstone cores 60-cm long are modeled. Results reported here for total...
Objective To evaluate the Jarvik 2000 axial flow left ventricular assist sys-tem (LVAS) as a bridge to transplant and destination therapy. Summary Background Data The LVAS was implanted in 22 patients (16 men, 6 women; mean age 53 years) (in United States) 4 (all men; 62.8 therapy Kingdom). All both of these initial feasibility studies were NYHA class 4. Methods pump through thoracotomy or median sternotomy incision with aid partial cardiopulmonary bypass bridge-to-transplant patients. A...