A5022649152- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Infective Endocarditis Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Cerebrovascular and Carotid Artery Diseases
- COVID-19 Clinical Research Studies
- Peripheral Artery Disease Management
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Long-Term Effects of COVID-19
- Aortic aneurysm repair treatments
- Venous Thromboembolism Diagnosis and Management
- Lipoproteins and Cardiovascular Health
- COVID-19 and healthcare impacts
- Diabetes Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Cardiac and Coronary Surgery Techniques
- Pericarditis and Cardiac Tamponade
Universidad Complutense de Madrid
2008-2022
Hospital Clínico San Carlos
2013-2022
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2012-2022
Fundación Instituto para la Mejora de la Asistencia Sanitaria
2022
Madrid Health Service
2021
Centro de Investigación Biomédica en Red
2020
Centro de Investigación en Red en Enfermedades Cardiovasculares
2020
Lung Institute
2018
Cardiovascular Institute of the South
2011-2015
University of Turin
2015
New-generation coronary stents that release zotarolimus or everolimus have been shown to reduce the risk of restenosis. However, it is unclear whether there are differences in efficacy and safety between two types on basis prospectively adjudicated end points endorsed by Food Drug Administration.In this multicenter, noninferiority trial with minimal exclusion criteria, we randomly assigned 2292 patients undergo treatment releasing either everolimus. Twenty percent were selected for repeat...
To assess platelet function profiles in diabetic and nondiabetic patients on aspirin clopidogrel therapy, two patient populations were included to investigate the 1) acute effects of a 300-mg loading dose (group 1, n = 52) 2) long-term 2, 120) compared with already treatment. Patients stratified according presence type 2 diabetes. Platelet aggregation was assessed using light transmittance aggregometry (groups 1 2). activation (P-selectin expression PAC-1 binding) determined whole-blood flow...
The 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors competitively inhibit biosynthesis of mevalonate, a precursor non-sterol compounds involved in cell proliferation. Experimental evidence suggests that fluvastatin may, independent any lipid lowering action, exert greater direct inhibitory effect on proliferating vascular myocytes than other statins. FLARE (Fluvastatin Angioplasty Restenosis) Trial was conceived to evaluate the ability 40mg twice daily reduce restenosis...
Background Percutaneous coronary revascularization (PCI) has been increasingly applied to unprotected left main trunk (LMT) lesions, with varied long-term success. This study attempts define the predictors of outcome in this population. Methods and Results Two hundred seventy-nine consecutive patients who had LMT PCI at 1 25 sites between 1993 1998 were studied. Forty-six percent these deemed inoperable or high surgical risk. Thirty-eight (13.7%) died hospital, rest followed up for a mean 19...
Metabolic activity of cytochrome P450 (CYP) 3A4 has been associated with clopidogrel response variability. Because metabolic CYP3A4 is genetically regulated, we hypothesized that genetic variations this enzyme may contribute to variability.The CYP3A4*1B, CYP3A4*3, IVS7+258A>G, IVS7+894C>T, and IVS10+12G>A polymorphisms the gene were assessed in 82 patients a steady phase therapy. Glycoprotein (platelet glycoprotein (GP) IIb/IIIa receptor activation platelet aggregation assessed. A cohort 45...
This report describes occupational radiation doses of interventional cardiologists over 15 years and assesses action undertaken to optimize protection. Personal dosimetry records nine staff eight cardiology fellows were recorded using personal dosemeters worn under their lead aprons. The hospital in which this study was conducted currently performs 5000 procedures per year. has improved its facilities since 1989, when it had two old-fashioned theatres, include four rooms with more advanced...
Background —The objective of this study was to assess the long-term clinical outcome and valvular changes (area regurgitation) after percutaneous mitral valvuloplasty (PMV). Methods Results —After PMV, 561 patients were followed up for 39 (±23) months clinical/echocardiographic data obtained yearly. Kaplan-Meier Cox regression analyses performed estimate event-free survival, its predictors, relative risks several patient subgroups. There nonexclusive events: 19 (3.3%) cardiac deaths, 55...