A5067276473- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Advanced MRI Techniques and Applications
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Peripheral Artery Disease Management
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Mechanical Circulatory Support Devices
- Cerebrovascular and Carotid Artery Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac tumors and thrombi
- Folate and B Vitamins Research
- Heart Failure Treatment and Management
- Ultrasound and Hyperthermia Applications
- MRI in cancer diagnosis
- Renal and Vascular Pathologies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Health and Disease Prevention
- Coronary Artery Anomalies
University of Debrecen
2014-2024
National Healthcare Service Center
2021-2024
Jósa András Múzeum
2011-2024
University of Nyíregyháza
2019-2024
Medical University of Vienna
2023
Clinical Trial Investigators
2022
This study sought to present a novel computer model for fast computation of myocardial fractional flow reserve (FFR) and evaluate it in patients with intermediate coronary stenoses.FFR is an indispensable tool identify individual stenoses causing ischemia. Calculation FFR from x-ray angiographic data may increase the utility assessment.Consecutive undergoing pressure wire-based measurements were analyzed by core laboratory. Three-dimensional quantitative angiography (QCA) was performed mean...
Oral activated factor XI (FXIa) inhibitors may modulate coagulation to prevent thromboembolic events without substantially increasing bleeding. We explored the pharmacodynamics, safety, and efficacy of oral FXIa inhibitor asundexian for secondary prevention after acute myocardial infarction (MI).We randomized 1601 patients with recent MI 10, 20, or 50 mg placebo once daily 6 12 months in a double-blind, placebo-controlled, phase 2, dose-ranging trial. Patients were within 5 days their...
Importance In patients with multivessel coronary artery disease (CAD) presenting ST-segment elevation myocardial infarction (STEMI), complete revascularization reduces major cardiovascular events compared culprit lesion–only percutaneous intervention (PCI). Whether also improves angina-related health status is unknown. Objective To determine whether angina in STEMI and CAD. Design, Setting, Participants This secondary analysis of a randomized, multinational, open label trial patient-reported...
The left internal mammary artery (LIMA) is the choice for grafting of anterior descending coronary (LAD). One possible mechanism rare graft failure involve presence competitive flow. 105 patients who had undergone bypass between 1998 and 2000 were included in this observational study. recatheterizations performed 28 months after operations. rate patency LIMA grafts was determined, cases with analyzed. patent 99 (94%). Six (6%) exhibited diffuse involution (string sign). string sign always...
Aims:The aim of this study was to develop a simplified model FFR calculation (FFR sim ) derived from three-dimensional (3D) coronary angiographic data and classic fluid dynamic equations without using finite element analysis.Methods results: Intracoronary pressure measurements were performed by wire sensors.The lumens the interrogated vessel segments reconstructed in 3D.The artery volumetric flow calculated based on velocity contrast material.Pressure gradients computed equations.The...
Abstract The effect of hydrostatic pressure on physiological intracoronary measurements is usually ignored in the daily clinical practice. Our aim was to investigate this Pd/Pa (distal/aortic pressure) and FFR (fractional flow reserve). 41 between 0.7 0.9 were selected. difference height orifice that sensor defined mm basis 3D coronary reconstruction. Resting adjusted by subtracting gradient from distal pressure. Height also performed 2D lateral projections for each segment (n = 305). In...
Background Microvascular resistance reserve (MRR) is a recently introduced specific index of coronary microcirculation. MRR calculation can utilize parameters deriving from flow (CFR) assessment, provided that intracoronary pressure data are also available. The previously proposed pressure-bounded CFR (CFRpb) defines the possible interval on basis resting and hyperemic gradients in epicardial vessel, however, its correlation to Doppler wire measurement was reported be rather poor without...
Evidence is conflicting regarding the clinical benefits of selecting P2Y12 inhibitors based on platelet function testing (PFT). Between March 1, 2013 and 2014, we collected characteristics data in a nationwide acute myocardial infarction (AMI) registry from 15 interventional cardiology centers Hungary. The risk all-cause mortality at 1 year were compared after propensity score (PS) matching between patients receiving PFT-guided unguided P2Y12-inhibitor therapies. High reactivity clopidogrel...
As demonstrated by earlier studies, pre-hospital triage with trans-telephonic electrocardiogram (TTECG) and direct referral for catheter therapy shows great value in the management of out-of-hospital chest pain emergencies. It does not only improve in-hospital mortality ST-segment elevation myocardial infarction, but it has also been identified as an independent predictor higher survival rate. Since TTECG-facilitated shortens both transport time percutaneous coronary intervention...
Purpose: To develop a method of coronary flow reserve (CFR) calculation derived from three-dimensional (3D) angiographic parameters and intracoronary pressure data during fractional (FFR) measurement. Methods: Altogether 19 arteries 16 native 3 stented vessels were reconstructed in 3D. The measured distal pressures corrected to the hydrostatic based on height differences between levels vessel orifice sensor position. Classical fluid dynamic equations applied calculate resting state...
Abstract: Introduction: There are conflicting data on the prevalence and prognosis of AMI patients with non-obstructive coronary artery disease (MINOCA). Aim: We studied MINOCA patients. Method: In Hungarian Myocardial Infarction Registry (HUMIR) 45,223 (pts) acute myocardial infarction (AMI) were found who treated between Jan 1, 2014, June 30, 2018, arteriography was performed. ST-elevation diagnosed in 22,469 pts (49.7%). Patients without obstructive had no previous infarction, heart...
Saphenous venous grafts (SVGs) are established choices for coronary artery bypass grafting (CABG); however, their lumen patency is limited. Our goal was to investigate the risk factors of SVG degeneration.Seventy-five patients (mean age, 57.5±10.4 years) with 133 conduits who had cardiac catheterization ≥1 year after CABG were selected; follow-up period 67.6±36.8 months. Patients divided into 3 groups according angiographic status at follow up [intact: <20% (n=23); narrowed: 20-99% (n=24);...
In order to make optimal decisions on the treatment of atherosclerotic coronary heart disease (CHD), appropriate evaluation is necessary, including both anatomical and physiological assessment arteries. According current guidelines, a fractional flow reserve (FFR)–based clinical decision recommended, but (CFR) measurements microvascular should also be considered in special cases for detailed exploration state. We aimed generate an extended during routine FFR measurement define new...
Wall motion abnormalities during acute ST-segment elevation myocardial infarction (STEMI) and the improvement after recanalization depend on conditions of coronary occlusion.Fifty-seven patients with first-ever STEMI due to one-artery occlusion, treated primary PCI, were evaluated. Area at risk left ventricular wall localized angiography echocardiography then compared in relation time elapsed from onset symptoms 3 months. Left diameters ejection fractions evaluated ischemic time.Three...
Background The functional significance of the anterograde and retrograde filling coronaries on angiography is controversial. Methods Results Eighteen patients with 27 severe lesions (>85% diameter stenosis) after previous extensive myocardial infarction were selected. left ventricle was divided into 33 segments for regional comparison epicardial flow (as assessed by angiography) tissue perfusion as well metabolism measured 13NH3− 18FDG-PET). Viability defined normal (>80% relative maximum...
Background: The authors analyzed data from the Hungarian Myocardial Infarction Registry (HUMIR) to examine potential impact of gender on treatment and 30-day 1-year mortality patients with myocardial infarction (MI). Materials Methods: National included 42,953 between January 1, 2013 December 31, 2016; 19,875 whom were diagnosed ST-elevation (STEMI) 23,078 non-ST-elevation (NSTEMI). proportion women was 39% 41.9% in two groups, respectively. Logistic regression analysis performed adjusting...
Measurements of fractional flow reserve (FFR) and/or coronary (CFR) are widely used for hemodynamic characterization lesions. The frequent combination the epicardial and microvascular disease may indicate a need complex evaluation This study aims at validating calculation CFR based on simple model to detailed computational fluid dynamics (CFD) analysis.
To investigate the correlations between three-dimensional (3D) parameters of target coronary artery segments and restenosis after stent implantation. Sixty-four patients single, cobalt chromium platform (27 BM stents 37 DES) implantation were investigated retrospectively 12 ± 6 months index procedure. 3D reconstruction was performed before using appropriate projections by a dedicated software. The curve segment characterized ratio vessel length measured at midline (arc: A) distance edge...