A5053528006- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Acute Myocardial Infarction Research
- Acute Ischemic Stroke Management
- Lattice Boltzmann Simulation Studies
- Advanced machining processes and optimization
- Tribology and Lubrication Engineering
- Heat and Mass Transfer in Porous Media
- Aerosol Filtration and Electrostatic Precipitation
- Aortic aneurysm repair treatments
- Ultrasound and Hyperthermia Applications
- Cerebrospinal fluid and hydrocephalus
- Mechanical Engineering Research and Applications
- Cardiovascular and Diving-Related Complications
- Spinal Hematomas and Complications
- Cardiac Valve Diseases and Treatments
- Microfluidic and Bio-sensing Technologies
- Force Microscopy Techniques and Applications
Budapest University of Technology and Economics
2018-2025
Applied Logic Laboratory (Hungary)
2024
Budapest University of Economics and Business
2021
Abstract Purpose The initiation of intracranial aneurysms has long been studied, mainly by the evaluation wall shear stress field. However, debate about emergence hemodynamic stimuli still persists. This paper builds on our previous hypothesis that secondary flows play an important role in formation cascade examining relationship between flow physics and vessel geometry. Methods A composite framework was developed to analyze simulated field perpendicular cross-sections along arterial...
Virtual flow diverter deployment techniques underwent significant development during the last couple of years. Each existing technique displays advantageous features, as well limitations. One common drawback is lack quantitative validation mechanics device. In following work, we present a new spring-mass-based method with validated mechanical responses that combines many useful capabilities previous techniques. The structure virtual braids naturally incorporates axial length changes function...
The Common Carotid Artery plays a vital role in supplying the brain, and its bifurcation is susceptible to vascular diseases. It often analyzed using computational fluid dynamics (CFD) simulations, but it challenging prescribe boundary conditions that approach patient-specific flow conditions. We examined six condition (BC) groups determine most accurate aligning with available measured data. conducted CFD simulations on stenotic carotid bifurcation, Doppler ultrasound sonography velocity...
Background Microvascular resistance reserve (MRR) is a recently introduced specific index of coronary microcirculation. MRR calculation can utilize parameters deriving from flow (CFR) assessment, provided that intracoronary pressure data are also available. The previously proposed pressure-bounded CFR (CFRpb) defines the possible interval on basis resting and hyperemic gradients in epicardial vessel, however, its correlation to Doppler wire measurement was reported be rather poor without...
Purpose: To develop a method of coronary flow reserve (CFR) calculation derived from three-dimensional (3D) angiographic parameters and intracoronary pressure data during fractional (FFR) measurement. Methods: Altogether 19 arteries 16 native 3 stented vessels were reconstructed in 3D. The measured distal pressures corrected to the hydrostatic based on height differences between levels vessel orifice sensor position. Classical fluid dynamic equations applied calculate resting state...
Abstract Purpose Intracranial aneurysms are malformations forming bulges on the walls of brain arteries. A flow diverter device is a fine braided wire structure used for endovascular treatment aneurysms. This work presents rig and protocol measurement hydrodynamic resistance stents. Hydrodynamic interpreted here as pressure loss versus volumetric rate function through mesh structure. The difficulty very low range extreme sensitivity to contamination disturbances. Methods Rigorous attention...
In order to make optimal decisions on the treatment of atherosclerotic coronary heart disease (CHD), appropriate evaluation is necessary, including both anatomical and physiological assessment arteries. According current guidelines, a fractional flow reserve (FFR)–based clinical decision recommended, but (CFR) measurements microvascular should also be considered in special cases for detailed exploration state. We aimed generate an extended during routine FFR measurement define new...
Binding force between biomolecules has a crucial role in most biological processes. Receptor-ligand interactions transmit physical forces and signals simultaneously. Previously, we employed robotic micropipette both live cell microbead adhesion studies to explore the of such as surface receptors including specific integrins on immune cells. Here apply standard computational fluid dynamics simulations reveal detailed background flow generated by when probing functionalized surfaces. Measuring...
Measurements of fractional flow reserve (FFR) and/or coronary (CFR) are widely used for hemodynamic characterization lesions. The frequent combination the epicardial and microvascular disease may indicate a need complex evaluation This study aims at validating calculation CFR based on simple model to detailed computational fluid dynamics (CFD) analysis.
Despite the high efficacy of flow diverters (FD) in treating sidewall intracranial aneurysms, failures are reported. One physical factors determining is reducing capacity FD that currently unknown to operator. Our aim was measure expressed as hydrodynamic resistance (HR), metallic surface area (MSA) and pore density (PD) two different designs quantitatively investigate impact sizing deployment technique on these parameters.Altogether 38 Pipeline (Medtronic) P64 (Phenox) FD‑s were implanted...
Background: The image reconstruction of stenotic carotid bifurcation can be managed by medical practitioners and non-medical investigators with semi-automatic or manual segmentation. outcome blood flow simulations may vary because a single mean voxel difference along the examined section, possibly more in lesions, which lead to conflicting results regarding other research findings. aim our project is computational geometry for make it suitable comparison plaque analysis performed...
The high efficacy of flow diverters (FD) in the case wide-neck aneurysms is well demonstrated, yet new challenges have arisen because reported posttreatment failures and growing number generation devices. Our aim to present a measurement-supported silico workflow that automates virtual deployment subsequent hemodynamic analysis FDs. In this work, objective analyze effects FD variability two manufacturers on reduction.
This review aims to explore advancements in perioperative ischemic stroke risk estimation for asymptomatic patients with significant carotid artery stenosis, focusing on Circle of Willis (CoW) morphology based the CTA or MR diagnostic imaging current preoperative algorithm. Functional transcranial Doppler (fTCD), near-infrared spectroscopy (NIRS), and optical coherence tomography angiography (OCTA) are discussed context evaluating cerebrovascular reserve capacity collateral vascular systems,...
This paper presents a novel method for the evaluation of three-dimensional blood-flow simulations based, on decomposition velocity field into localized coordinate systems along vessels centerline. The is based computation accurate centerlines with Vascular Modeling Toolkit (VMTK) library, to calculate Frenet-frames centerline and morphological features, namely curvature torsion. Using Frenet-frame unit vectors, can be decomposed axial, circumferential radial components visualized in diagram...
Potential pitfalls of fractional flow reserve (FFR) measurements are well-known drawbacks invasive physiology measurement, e.g., significant drift the distal pressure trace may lead to misclassification stenoses. Thus, a simultaneous waveform analysis traces be help in quality control these by online detection such artefacts as or wedging catheter. In current study, we analysed intracoronary with dedicated program. 130 patients, 232 FFR were performed and derivative curves calculated. Local...
Abstract Purpose: To develop a method of coronary flow reserve (CFR) calculation derived from threedimensional (3D) angiographic parameters and intracoronary pressure data during fractional (FFR) measurement. Methods: Altogether 19 arteries 16 native 3 stented vessels were reconstructed in 3D. The measured distal pressures corrected to the hydrostatic based on height differences between levels vessel orifice sensor position. Classical fluid dynamic equations applied calculate resting state...
Different methods are established for the changes in aortic valve stenosis with cardiac computed tomography angiography (CCTA), but effect of grade on contrast densities around has not been investigated.Using information from flow dynamics cases increased velocity through narrowed lumen, hypothesis was formed that can alter stenotic post-valvular regions, and density might correlate stenosis. Forty patients severe fifteen a normal were enrolled. With echocardiography, peak/mean transvalvular...
Abstract Purpose To develop a method of coronary flow reserve (CFR) calculation derived from three-dimensional (3D) angiographic parameters and intracoronary pressure data during fractional (FFR) measurement. Methods Altogether 19 arteries 16 native 3 stented vessels were reconstructed in 3D. The measured distal pressures corrected to the hydrostatic based on height differences between levels vessel orifice sensor position. Classical fluid dynamic equations applied calculate resting state...
Az aneurizmák (értágulatok) legfőbb veszélyét az jelenti, hogy érfalra ható igénybevételek miatt kirepedhetnek, ezáltal súlyos belső vérzést, halált okozhatnak. Ha azonban orvosnak rendelkezésére állnak olyan mérnöki eszközök, mint például artériák elemzésére alkalmas numerikus modellek, szimulációk, ezek segítségével el lehet dönteni, egy adott értágulatnál szükséges-e a beavatkozás, és amennyiben igen, mikor. ilyen modellekhez áramlásirányító eszközök mechanikai jellemzői bemeneti adatok....
Abstract The main danger of a brain aneurysm (a sack-like bulge on the vessel wall) is that in event rupture severe hemorrhage can occur which may cause death. However, if doctors have tools at their disposal, such as numerical models and simulations for analyzing patient-specific blood vessels, they could use them to decide particular treatment necessary so, when. For models, different mechanical characteristics flow control devices are input data. Several these properties devices, modulus...