A5106230299- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac Arrest and Resuscitation
- Cardiac Health and Mental Health
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Risk Factors
- Emergency and Acute Care Studies
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrhythmias and Treatments
- Takotsubo Cardiomyopathy and Associated Phenomena
- Heart Failure Treatment and Management
- Cardiovascular Disease and Adiposity
- Cardiovascular Effects of Exercise
- Trauma and Emergency Care Studies
- Healthcare Policy and Management
- Indigenous Health, Education, and Rights
- Travel-related health issues
- Cerebrovascular and Carotid Artery Diseases
- Heart Rate Variability and Autonomic Control
- Advanced MRI Techniques and Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Health Systems, Economic Evaluations, Quality of Life
The University of Adelaide
2016-2025
Central Adelaide Local Health Network
2016-2025
Basil Hetzel Institute
2013-2025
Queen Elizabeth Hospital
2013-2025
Women's and Children's Health Network
2015-2024
Royal Adelaide Hospital
2016-2024
Clinical Trial Investigators
2022
Health Net
2015-2022
SA Health
2015-2021
Lyell McEwin Hospital
2008-2020
Background: Contemporary ST-segment–elevation myocardial infarction management involves primary percutaneous coronary intervention, with ongoing studies focusing on infarct size reduction using ancillary therapies. N-acetylcysteine (NAC) is an antioxidant reactive oxygen species scavenging properties that also potentiates the effects of nitroglycerin and thus represents a potentially beneficial therapy in intervention. The NACIAM trial (N-acetylcysteine Acute Myocardial Infarction) examined...
<h3>Objective</h3> Tako-Tsubo cardiomyopathy (TTC) is associated with regional left ventricular dysfunction, independent of the presence fixed coronary artery disease. Previous studies have used T2-weighted cardiac MRI to demonstrate periapical oedema. The authors sought determine distribution, resolution and correlates oedema in TTC. <h3>Patients</h3> 32 patients TTC were evaluated at a median 2 days after presentation, along 10 age-matched female controls. Extent was quantified both...
Importance In patients with multivessel coronary artery disease (CAD) presenting ST-segment elevation myocardial infarction (STEMI), complete revascularization reduces major cardiovascular events compared culprit lesion–only percutaneous intervention (PCI). Whether also improves angina-related health status is unknown. Objective To determine whether angina in STEMI and CAD. Design, Setting, Participants This secondary analysis of a randomized, multinational, open label trial patient-reported...
Objective To investigate the role of angiotensin-converting enzyme-related carboxypeptidase (ACE2) in angiotensin peptide metabolism human coronary circulation. Methods Angiotensin I and II, their respective metabolites, angiotensin-(1–9) angiotensin-(1–7), were measured arterial sinus blood heart failure subjects receiving enzyme (ACE) inhibitor therapy normal not ACE therapy. In addition, I, II angiotensin-(1–7) with artery disease before, at 2, 5 10 min after, intravenous administration...
St John Ambulance Operations Branch Volunteers have been providing first-aid services at the Royal Adelaide Show for 90 years. The project arose from a need to more accurately predict workload providers mass gathering events. A formal analysis of patterns and determinants had not performed.Casualty presentation would be predicted by factors including day week, weather, crowd size.Collated analyzed casualty reports over seven-year period representing >7,000 patients who presented assistance...
Limited strategies have been developed to evaluate and address the alarming discrepancy in early mortality between Indigenous non-Indigenous populations.
Background/Objectives: The diagnosis of coronary artery spasm (CAS) frequently requires invasive provocation testing, typically utilising acetylcholine (ACh). Although the left (LCA) is routinely assessed as a part testing protocol, assessment right (RCA) often avoided since it insertion temporary pacing wire. We sought to compare prevalence inducible CAS in LCA and RCA, among patients with undergoing multivessel ACh. Methods: A local multi-institutional ANOCA (angina non-obstructive...
Abstract Background In patients undergoing invasive coronary angiography for the investigation of angina, management pathways obstructive artery disease (CAD) are well described, whereas clinical and diagnostic journey with ANOCA has largely been inferred, as there is limited quantitative data. Objectives To compare versus Obstructive CAD, particularly in relation to (i) presentation (ii) assessment, (iii) 12 month patient-reported outcome measures (PROMs) (iv) three year composite MACE...
Background— High-sensitivity troponin T (hs-TnT) assays promise greater discrimination of evolving myocardial infarction, but the impact unguided implementation on effectiveness care is uncertain. Methods and Results— We evaluated hs-TnT reporting outcome among chest pain patients presenting to 5 emergency departments within a multicenter randomized trial. Patients were allocated (hs-report) or standard (std-report; Roche Elecys). The primary end point was death new recurrent acute coronary...
Non-ST elevation myocardial infarction (NSTEMI) has higher post-discharge mortality than ST-elevation (STEMI). Prognosis worsens in those with multivessel coronary disease (MVD). However, information about the prevalence and extent of MVD NSTEMI is limited, turn limiting insights into optimal treatment strategies. This study aimed to define MVD, preferred strategies predictors a real-world population.The Coronary Angiogram Database South Australia (CADOSA) was used identify consecutive...
Factors associated with in-hospital mortality after out-of-hospital cardiac arrest (OHCA), such as mode of death and withdrawal life-sustaining treatment (WLST), are not well established. This study aimed to compare clinical characteristics, timing WLST death, precipitating aetiology between modes for OHCAs treated at hospital within a local health network.Retrospective cohort adult non-traumatic included in based OHCA registry 2011 2016 deceased discharge, excluding cases retrieved external...