A5073903459- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Breast Cancer Treatment Studies
- Frailty in Older Adults
- Chronic Disease Management Strategies
- Nutritional Studies and Diet
- Breast Lesions and Carcinomas
- Autoimmune and Inflammatory Disorders Research
- Breast Implant and Reconstruction
- Acute Myocardial Infarction Research
- Consumer Attitudes and Food Labeling
- Medication Adherence and Compliance
- Advanced Breast Cancer Therapies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Adolescent and Pediatric Healthcare
- Nutrition and Health in Aging
- Heart Failure Treatment and Management
- Acute Lymphoblastic Leukemia research
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Antibiotic Use and Resistance
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Gene expression and cancer classification
- Coronary Interventions and Diagnostics
Mario Negri Institute for Pharmacological Research
2019-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2025
Government of Western Australia Department of Health
2024
Azienda Ospedaliera Universitaria Senese
2023
Policlinico S.Orsola-Malpighi
2023
Ospedale San Paolo
2023
IRCCS Ospedale San Raffaele
2023
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2023
University of Milan
2009-2019
Fondazione IRCCS Istituto Nazionale dei Tumori
2010-2017
To assess the role of axillary dissection in older breast cancer patients with a clinically clear axilla.Axillary dissection, once standard treatment for cancer, is associated considerable morbidity. It has been substituted by sentinel node biopsy only if positive. We aimed to determine whether surgery can be omitted women, thereby sparing them morbidity, without compromising long-term disease control.We carried out randomized clinical trial on 238 (65-80 years) patients, N0 radiographic...
This study was conducted to develop a histology-specific nomogram predict postoperative overall survival (OS) at 5 and 10 years in primary retroperitoneal soft tissue sarcoma (STS).Data registered single institution (National Cancer Institute, Milan, Italy) prospective database were used. In the present analysis, patients with localized STS resected curative intent between 1985 2007 included. A parametric piecewise exponential multivariate model used for development, internal validation...
The purpose of this study was to characterize the recurrence dynamics in breast cancer patients after delayed reconstruction. We hypothesized that surgical reconstruction might stimulate dormant micrometastases and reduce time recurrence. All mastectomy with at Haukeland University Hospital, between 1977 2007, n = 312, were studied. Our control group consisted 1341 without For each case, all identical T N stages age ±2 years considered. A paired randomly selected from group. 10 primary...
Because frailty is a complex phenomenon associated with poor outcomes, the identification of patient profiles different care needs might be greater practical help than to look for unifying definition. This study aimed at identifying aging phenotypes and their related outcomes in order recognize hospitalized older patients. Patients aged 65 or enrolled internal medicine geriatric wards participating REPOSI registry. Relationships among variables sociodemographic, physical, cognitive,...
To evaluate medication adherence and associated factors of seven the most common drug classes prescribed to community-dwelling older people.This is a retrospective cohort study on in people (65-94 years old) chronic polypharmacy recorded from 2013 2015 administrative database Lombardy region (Northern Italy). Adherence was assessed for diabetic drugs, antithrombotic agents, drugs acting renin-angiotensin system, statins, bisphosphonates, antidepressants obstructive airway diseases by...
Poor medication adherence compromises treatment efficacy and adversely affects patients' clinical outcomes. This study aims to assess (1) multiple the most common drug classes chronically prescribed older people, (2) factors associated, (3) retrospective cohort included 122,655 community-dwelling patients aged 65-94 years old, newly exposed chronic polypharmacy, recorded in Lombardy Region (northern Italy) administrative database from 2016 2018. Multiple was assessed for drugs diabetes,...
Proton pump inhibitors (PPIs) are among the most commonly and inappropriately prescribed drugs by general practitioners (GPs), resulting in increased risk of adverse outcomes for patients avoidable costs Italy's National Health Service (NHS). This study aims to assess effectiveness a low-cost easily implementable informative intervention directed at GPs enhance appropriate prescription PPIs. The LAPTOP-PPI is pragmatic, cluster-randomized controlled trial designed improve appropriateness PPI...
the study was designed to determine how tumour hormone receptor status affects subsequent pattern over time (dynamics) of breast cancer recurrence and death following conservative primary resection. Time span from resection until both first were considered among 2825 patients undergoing surgery with or without radiotherapy. The hazard rates for ipsilateral (IBTR), distant metastasis (DM) mortality throughout 10 years follow-up assessed. DM dynamics displays same bimodal (first early peak at...
( Cancer Sci 2010; 101: 826–830) The purpose was to ascertain whether the recurrence risk patterns for patients with estrogen receptor (ER)‐positive (P) and ER‐negative (N) breast cancer support ER‐related clinical divergence suggested by observed different mortality gene expression profiles. Both death were considered in a series of 771 undergoing mastectomy. ER status available 539 patients. hazard rates throughout 15 years follow‐up assessed. dynamics displays bimodal pattern both ERP ERN...
Genomic analysis and protein expression assimilate triple-negative breast cancers (TNBC) with basal-like tumors. TNBCs, however, have proved to encompass also tumors normal-like phenotype known favorable prognosis respond chemotherapy. In a recent paper, we provided evidence that p53 status is able subdivide TNBCs into two distinct subgroups different outcome, consistent basal- phenotypes. Based on this finding, explored the contribution of in predicting response adjuvant CMF or followed...
Chronic obstructive pulmonary disease (COPD) and heart failure (HF) mutually increase the risk of being present in same patient, especially if older. Whether or not this coexistence may be associated with a worse prognosis is debated. Therefore, employing data derived from REPOSI register, we evaluated clinical features outcomes population elderly patients admitted to internal medicine wards having COPD, HF COPD + HF.We measured socio-demographic anthropometric characteristics, severity...
Aims Antiplatelet therapy is recommended for the secondary prevention of cardio‐ and cerebrovascular disease, but primary it advised only in patients at very high risk. With this background, study aims to assess appropriateness antiplatelet acutely hospitalized older people according their risk profile. Methods Data were obtained from REPOSI register held Italian Spanish internal medicine geriatric wards 2012 2014. Hospitalized aged ≥65 assessable discharge selected. Appropriateness was...
Abstract Aims The association between hyperglycemia at hospital admission and relevant short- long-term outcomes in elderly population is known. We assessed the effects on mortality of hyperglycemia, disability, multimorbidity internal medicine ward patients aged ≥ 65 years. Methods Data were collected from an active register 102 geriatric wards Italy (RePoSi project). Patients recruited during four index weeks a year. Socio-demographic data, reason for hospitalization, diagnoses, treatment,...
Fish is among the foods exerting favourable effects on colorectal cancer (CRC), but possible role of canned fish has been insufficiently investigated. We aimed to investigate relationship between consumption and CRC risk. analysed data from two case–control studies conducted 1992 2010 in several Italian areas, comprising a total 2419 incident cases 4723 hospital controls. Canned was according weekly frequency as <1 serving per week (s/w) (reference category), 1 < 2 s/w, ≥2 s/w....
The objective of this study was to determine long-term effectiveness and safety 1st biological treatment (BT) in a cohort 301 juvenile idiopathic arthritis (JIA) patients (pts), non-responders disease-modifying antirheumatic drugs (DMARDs), terms drug survival (continuation rate on therapy) identify the baseline predictors discontinuation. Each JIA pt enrolled BT is prospectively assessed at start then every 2 months for evaluation efficacy according ACR-Pedi30 criteria. All clinical charts...