A5054588744- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Lipids, and Metabolism
- Blood Pressure and Hypertension Studies
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 Clinical Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Angiogenesis and VEGF in Cancer
- Cholesterol and Lipid Metabolism
- HIV-related health complications and treatments
- Liver Disease Diagnosis and Treatment
- Microbial Metabolism and Applications
- Cerebrovascular and Carotid Artery Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Hormonal Regulation and Hypertension
- Biomarkers in Disease Mechanisms
- Heart Rate Variability and Autonomic Control
- Systemic Lupus Erythematosus Research
- Bone and Joint Diseases
- Cardiovascular Function and Risk Factors
- Peripheral Artery Disease Management
- Bone health and osteoporosis research
- Pharmaceutical Practices and Patient Outcomes
University of Perugia
2015-2024
Azienda Ospedaliera Universitaria Senese
2023
Policlinico S.Orsola-Malpighi
2023
Ospedale San Paolo
2023
IRCCS Ospedale San Raffaele
2023
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2023
Women's College Hospital
2023
McGill University
2021
Ospedale Santa Maria
2020
Italian Society of Physiotherapy
2016
Metabolic syndrome is a powerful predictor of cardiovascular disease in hypertension, and large-artery stiffness increasingly recognized as risk factor. We hypothesized that the adverse prognostic significance metabolic hypertension might be explained part by its association with aortic stiffness. A total 169 newly diagnosed, never treated, nondiabetic patients essential (men 55%, 48+/-11 years) were classified presence (n=45) or absence (n=124) syndrome. All underwent upper limb pulse wave...
Particulate matter exposure has been associated with the appearance and severity of several diseases, including viral infections. The aim this study was to investigate whether coronavirus disease 2019 (COVID-19) cases deaths across Italian regions provinces in March 2020 were linked past fine coarse particulate (namely, PM2.5 PM10, respectively).Geographical distributions COVID-19 (105,792 12,428, respectively, up 31st 2020), PM10 exposure, demographic characteristics extracted from publicly...
Ambulatory arterial stiffness index (AASI), a measure based on the relative behavior of 24-hour systolic and diastolic blood pressure (BP), has been suggested as marker predictor cardiovascular mortality. However, narrow range BP values over 24 hours tends to flatten regression slope artificially increase AASI. We explored possible influence different ranges fluctuations, such those related nocturnal fall, AASI, its relationship with target organ damage. In 515 untreated hypertensive...
Atherosclerosis may be caused by increased endothelial damage and a consumptive loss of repair capacity progenitors. Arterial stiffness is reliable marker atherosclerosis positive correlate damage. We investigated whether an ratio CD31+/CD42- microparticles to progenitors, possible indicator impaired endothelium reparation, contribute aortic in hypercholesterolemia. also studied the vitro effect from hypercholesterolemic patients on progenitor survival.Circulating microparticles, pulse wave...
Metabolic syndrome (MS) is increasingly recognized as an important cardiovascular risk factor in hypertension, but its influence on left ventricular (LV) mass and function the 2 genders has not been specifically addressed. Among 618 nondiabetic, untreated hypertensive subjects, echocardiographically detected LV was significantly greater subjects with MS. A significant interaction observed between sex MS (P<0.003 for multiplicative term). Compared women without MS, those had a 24% (49.5+/-12...
HIV infection is associated with chronic immune activation, subclinical inflammation, and an atherogenic metabolic profile. It remains controversial whether a risk factor for accelerated arteriosclerosis independent from the effects of antiretroviral drugs. We investigated aortic stiffness, early marker arteriosclerosis, increased in patients who were not under treatment. In 39 untreated HIV-infected 78 individually matched age-, sex-, blood pressure–matched HIV-uninfected control subjects,...
Chronic kidney disease is accompanied by increased large-artery stiffness, but the relation between glomerular filtration rate within reference range and central or peripheral arterial stiffness has been understudied. The link renal function was assessed in 305 patients with never-treated essential hypertension (men: 58%; age: 48+/-11 years, blood pressure: 151/95+/-20/11 mm Hg), free from overt cardiovascular serum creatinine values <1.4 mg/dL (men) <1.2 (women), who underwent noninvasive...
Circulating endothelial progenitor cells (EPCs) differentiate into mature and regenerate the injured endothelium. The role of homeobox A9 (HOXA9) is critical for commitment during cell maturation, postnatal neovascularization vascular repair. objective our study was to measure expression HOXA9 in CD34+ from hypertensive patients investigate its correlation with number circulating EPCs.Thirty newly diagnosed, never-treated essential hypertension 30 age- sex-matched normotensive controls were...
Experimental CCR5 antagonism with maraviroc in atherosclerosis-prone mice and preliminary data humans suggest an anti-atherosclerotic effect of the drug. We assessed impact treatment persons living HIV on subclinical indicators atherosclerosis.Persons effective antiretroviral therapy (ART) including only protease inhibitors were recruited if they had a Framingham risk score >20% brachial flow-mediated dilation (bFMD) <4%, as indices high cardiovascular risk. Maraviroc (300 mg per os for 24...
The role of antiretroviral therapy in acceleration atherosclerosis patients with human immunodeficiency virus (HIV) infection is controversial. We hypothesized that aortic stiffness, an early marker arteriosclerosis, may be increased HIV treated protease inhibitors.In 32 HIV-infected inhibitors and age-, sex-, blood pressure-matched HIV-uninfected control subjects, we obtained pulse wave velocity central pressure waveform, from which augmentation was calculated. had a higher (7.6+/-1.1...
Aortic pulse wave velocity (PWV), generally considered an intrinsic marker of arterial stiffness, might depend in part on the myocardial fiber shortening, but relation between PWV and function humans has been understudied. A total 237 untreated hypertensive subjects over a wide age range (18 to 88 years) underwent aortic determination echocardiography, from which mean circumferential shortening was calculated as measure relative wall thickness taken left ventricular concentric remodeling....
Endothelial progenitor cells maintain endothelium integrity by replacing injured endothelial cells. Cholesterol-lowering promotes either mobilization or improves function. It is unknown whether improving function with statin associated a parallel increased availability. Thirty-two hypercholesterolemic patients were assigned to 4-week rosuvastatin (10 mg daily) and 16 served as controls. Circulating cells, brachial artery flow-mediated vasodilatation, an index of function, the lipid profile...
Migraine has been associated with an increased risk for ischemic stroke and other cardiovascular (CV) events, including angina, myocardial infarction, CV death, but the mechanisms that link migraine to disease remain uncertain. We hypothesized aortic pulse wave velocity (PWV), a direct measure of stiffness independent predictor disease, may be in young migraineurs no overt or major factors.We studied 60 subjects (age 33 ± 8 years, 85% women, blood pressure 119/74 11/9 mm Hg) age-, sex-,...
Systemic inflammation and imbalance between endothelial injury repair, the latter referred to as vascular incompetence, are associated with atherosclerosis cardiovascular risk. Psoriasis, an inflammatory disease of skin, has been atherosclerosis. We investigated whether, in psoriasis, incompetence carotid intima-media thickness (cIMT) irrespective metabolic syndrome other established risk factors. High sensitivity C-reactive protein (hsCRP), ratio microparticles (EMPs) progenitors (EPCs), a...