A5049744281- Adenosine and Purinergic Signaling
- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Inflammatory mediators and NSAID effects
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Neuropeptides and Animal Physiology
- Vagus Nerve Stimulation Research
- Microscopic Colitis
- Diet and metabolism studies
- Gut microbiota and health
- Eosinophilic Esophagitis
- Inflammasome and immune disorders
- Parkinson's Disease Mechanisms and Treatments
- IL-33, ST2, and ILC Pathways
- Restless Legs Syndrome Research
- Calcium signaling and nucleotide metabolism
- Peptidase Inhibition and Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroscience of respiration and sleep
- Nitric Oxide and Endothelin Effects
- Adolescent and Pediatric Healthcare
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Pharmacological Receptor Mechanisms and Effects
University of Pisa
2016-2025
Politecnico di Milano
2022
Morristown Medical Center
2017-2022
Columbia University Irving Medical Center
2022
American College of Surgeons
2022
E Ink (South Korea)
2022
University of Genoa
2021
National Center for Oncological Hadrontherapy
2021
University of Padua
2015-2020
Seoul National University
2020
Pharmacological inhibition of NLRP3 inflammasome activation may offer a new option in the treatment inflammatory bowel disease. In this work, we report design, synthesis, and biological screening series acrylate derivatives as inhibitors. The vitro determination reactivity, cytotoxicity, ATPase inhibition, antipyroptotic properties allowed selection 11 (INF39), nontoxic, irreversible inhibitor able to decrease interleukin-1β release from macrophages. Bioluminescence resonance energy transfer...
Extracellular ATP binds to and signals through P2X7 receptors (P2X7Rs) modulate immune function in both inflammasome-dependent -independent manners. In this study, P2X7(-/-) mice, the pharmacological agonists ATP-magnesium salt (Mg-ATP; 100 mg/kg, EC50 ≈ 1.32 mM) benzoylbenzoyl-ATP (Bz-ATP; 10 285 μM), antagonist oxidized (oxi-ATP; 40 IC50 μM) were used show that P2X7R activation is crucial for control of mortality, bacterial dissemination, inflammation cecal ligation puncture-induced...
Networks of cytokines have been implicated in both forms inflammatory bowel disease (IBD): Crohn's (CD) and ulcerative colitis (UC). While CD has associated with T-helper type 1 (Th1) immune responses, UC shows Th2 patterns. Recent studies reported that the inflamed intestinal regions are significantly infiltrated a newly described set T helper, Th17 cells. These cells unique cytokine responses. findings prompted us to further explore profiles special focus on related mediators.Cytokine...
Collagen detection in histological sections and its quantitative estimation by computer-aided image analysis represent important procedures to assess tissue localization distribution of connective fibers. Different histochemical approaches have been proposed detect quantify collagen deposition paraffin slices with different degrees satisfaction. The present study was performed compare the qualitative efficiency three methods available for staining colon. van Gieson, Sirius Red Red/Fast Green...
Parkinson's disease (PD) is frequently associated with gastrointestinal (GI) symptoms, including constipation and defecatory dysfunctions. The mechanisms underlying such disorders are still largely unknown, although the occurrence of a bowel inflammatory condition has been hypothesized. This study examined impact central dopaminergic degeneration, induced by intranigral injection 6-hydroxydopamine (6-OHDA), on distal colonic excitatory tachykininergic motility in rats. Animals were...
Abstracts Bowel inflammation, impaired intestinal epithelial barrier (IEB), and gut dysbiosis could represent early events in Parkinson’s disease (PD). This study examined, a descriptive manner, the correlation among enteric α-synuclein, bowel impairments of IEB alterations bacteria transgenic (Tg) model PD before brain pathology. Human A53T α-synuclein Tg mice were sacrificed at 3, 6, 9 months age to evaluate concomitance impairments, bacterial metabolite during phases α-synucleinopathy....
Background: Experimental evidence suggests a key role of SIRT1 (silent information regulator 1) in age- and metabolic-related vascular dysfunction. Whether these effects hold true the human microvasculature is unknown. We aimed to investigate very early stages obesity-related microvascular dysfunction humans. Methods: Ninety-five subjects undergoing elective laparoscopic surgery were recruited stratified based on their body mass index status (above or below 30 kg/m 2 ) age 40 years) 4...
Adenosine modulates the immune system and inhibits inflammation via reduction of cytokine biosynthesis neutrophil functions. Drugs able to prevent adenosine catabolism could represent an innovative strategy treat inflammatory bowel disorders. In this study, effects 4-amino-2-(2-hydroxy-1-decyl)pyrazole[3,4-<i>d</i>]pyrimidine (APP; novel deaminase inhibitor), <i>erythro</i>-9-(2-hydroxy-3-nonyl)adenine hydrochloride (EHNA; standard dexamethasone were tested in rats with colitis induced by...