A5073854011- Ovarian function and disorders
- Nerve injury and regeneration
- Genetics and Neurodevelopmental Disorders
- Pain Mechanisms and Treatments
- Reproductive Biology and Fertility
- MicroRNA in disease regulation
- Hereditary Neurological Disorders
- Neurogenesis and neuroplasticity mechanisms
- Restless Legs Syndrome Research
- Endometriosis Research and Treatment
- COVID-19 and Mental Health
- Parkinson's Disease Mechanisms and Treatments
- Autism Spectrum Disorder Research
- Child Nutrition and Feeding Issues
- Physical Activity and Health
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Cardiovascular Effects of Exercise
- Cardiac, Anesthesia and Surgical Outcomes
- Growth Hormone and Insulin-like Growth Factors
- Pain Management and Placebo Effect
- Antibiotic Resistance in Bacteria
- Genomic variations and chromosomal abnormalities
- Advanced Biosensing Techniques and Applications
Scuola Normale Superiore
2014-2023
University of Pisa
2000-2020
Sapienza University of Rome
1994-2016
Ospedale Infermi di Rimini
2011
Ospedale Monaldi
2007
University of Insubria
1999-2001
Mario Negri Institute for Pharmacological Research
2001
University of Milan
1990-1998
University of Pavia
1997-1998
Summary The brains of teleost fish show extensive adult neurogenesis and neuronal regeneration. patterns gene regulation during brain aging are unknown. short‐lived Nothobranchius furzeri shows markers including reduced learning performances, gliosis, neurogenesis. We used RNA ‐seq to quantify genome‐wide transcript sampled five different time points characterize whole‐genome N. . Comparison with human datasets revealed conserved up‐regulation ribosome, lysosome, complement activation...
Abstracts Bowel inflammation, impaired intestinal epithelial barrier (IEB), and gut dysbiosis could represent early events in Parkinson’s disease (PD). This study examined, a descriptive manner, the correlation among enteric α-synuclein, bowel impairments of IEB alterations bacteria transgenic (Tg) model PD before brain pathology. Human A53T α-synuclein Tg mice were sacrificed at 3, 6, 9 months age to evaluate concomitance impairments, bacterial metabolite during phases α-synucleinopathy....
Premature ovarian failure is defined as cessation of function under the age 40 years and affects approximately 1% women in general population. The aetiology this disorder still unknown most cases. Although there have been some reports familial premature failure, very little known about incidence inheritance pattern its idiopathic form. aims study were to investigate a homogeneous group patients with menopause identify possible clinical differences between sporadic form failure. A total 71...
A total of 106 women affected by premature ovarian failure (POF) were evaluated for fragile X (FRAXA) premutation. The POF patients classified as having a familial condition (33 women), at least one relative with early menopause (12 or sporadic (61 women). FRAXA premutation was only detected in (four out 33) (two 61). In general, the results obtained indicated that prevalence [six 106, 6%, 95% confidence interval (CI) 3–11%] is significantly higher than expected (P = 1.24×10–3), suggesting...
Significance The correct interplay between mitochondria and nuclear functions is essential to generate the mature functional six-layered structure of mammalian cerebral cortex. Thus, alteration in this interaction results pathological conditions such as cancer or neurodevelopmental disorders. molecules signaling mechanisms responsible for nucleus–mitochondria communication coordination are still largely unknown. here-reported mitochondrial localization Forkhead box g1 (Foxg1), a...
Several works reported increased differentiation of neuronal cells grown on graphene; however, the molecular mechanism driving axon elongation this material has remained elusive. Here, we study axonal transport nerve growth factor (NGF), neurotrophin supporting development peripheral neurons, as a key player in time course dorsal root ganglion neurons graphene. We find that graphene drastically reduces number retrogradely transported NGF vesicles favor stalled population first two days...
Genetic factors may influence the timing of menopause. Premature ovarian failure (POF) has recently been identified as a genetic entity, but no data are available on early menopause (EM). We investigated 36 patients with EM (age between 40 and 45 years age) using cytogenetic pedigree analysis. In 30 this study was idiopathic 15 subjects (50%) had familial condition or POF. Pedigree analysis revealed dominant pattern inheritance through maternal paternal relatives. Our reveal that POF show...
Nerve growth factor (NGF) is critical for neuronal physiology during development and adulthood. Despite the well-recognized effect of NGF on neurons, less known about whether can actually affect other cell types in central nervous system (CNS). In this work, we show that astrocytes are susceptible to changes ambient levels NGF. First, observe interfering with signaling vivo via constitutive expression an antiNGF antibody induces astrocytic atrophy. A similar asthenic phenotype encountered...
The correct morphofunctional shaping of the cerebral cortex requires a continuous interaction between intrinsic (genes/molecules expressed within tissue) and extrinsic (e.g., neural activity) factors at all developmental stages. Forkhead Box G1 (FOXG1) is an evolutionarily conserved transcription factor, essential for patterning layering. FOXG1-related disorders, including congenital form Rett syndrome, can be caused by deletions, intragenic mutations or duplications. These genetic...
Mex3A is an RNA binding protein that can also act as E3 ubiquitin ligase to control gene expression at the post-transcriptional level. In intestinal adult stem cells, MEX3A required for cell self-renewal and when overexpressed, contribute support proliferation of different cancer types. a completely context, we found mex3A among genes expressed in neurogenic niches embryonic fish brain and, notably, its was downregulated during aging. The role neurogenesis tetrapods still unknown. Here,...
Nerve growth factor (NGF) is a key mediator of nociception, acting during the development and differentiation dorsal root ganglion (DRG) neurons, on adult DRG neuron sensitization to painful stimuli. NGF also has central actions in brain, where it regulates phenotypic maintenance cholinergic neurons. The physiological function as pain altered patients with Hereditary Sensory Autonomic Neuropathy type V (HSAN V), caused by 661C>T transition Ngf gene, resulting R100W missense mutation...
Background: Staphylococcus aureus is a leading cause of community-acquired infections and healthcare-associated infections. Epidemiological data are useful for understanding the dynamics diffusion this pathogen, to plan control activities monitor their efficacy. Methods: S. isolates were collected in 13 public hospital laboratories Emilia-Romagna (northern Italy region) during February–March 2009; phenotypic molecular characterizations these performed. Results: The study sample included 267...
We conducted a national retrospective survey of 1764 athletes aged ≤25 years to investigate the benefit–risk balance sport closure during COVID-19 pandemic peaks in Italy. Univariate and multivariable analyses were carried out association between practice study period (1) risk SARS-CoV-2 infection their families (2) body mass index (BMI) change, adherence World Health Organization (WHO) guidelines for physical activity. The percentage subjects with positive test was similar those...
Abstract The binding of nerve growth factor (NGF) to the tropomyosin–related kinase A (TrkA) and p75 NTR receptors activates a large variety pathways regulating critical processes as diverse proliferation, differentiation, membrane potential, synaptic plasticity, pain. To ascertain details TrkA‐p75 interaction cooperation, plethora experiments, mostly based on receptor overexpression or downregulation, have been performed. Among heterogeneous cellular systems used for studying NGF signaling,...
Objective of this case-control study was to investigate the potential risk factors for premature ovarian failure (POF). Seventy-three patients with secondary hypergonadotropic amenorrhea and, as control group, 144 women acute, non-gynecological, non-neoplastic, non-hormone-related diseases were included in study. Information obtained on sociodemographic characteristics, gynecological and obstetric data, general lifestile habits, smoking habits history selected other clinical conditions. A...
Abstract Rett syndrome is a rare genetic neurodevelopmental disease, affecting 1 in over 10 000 females born worldwide, caused by de novo mutations the X-chromosome-located methyl-CpG-binding protein 2 (MeCP2) gene. Despite great effort put forth scientific community, therapy for this devastating disease still needed. Here, we tested therapeutic effects of painless mutein nerve growth factor (NGF), called human NGF (hNGFp), via non-invasive intranasal delivery female MeCP2+/− mice. Of note,...