A5016840417- Colorectal Cancer Treatments and Studies
- Veterinary Equine Medical Research
- Radiomics and Machine Learning in Medical Imaging
- Pain Mechanisms and Treatments
- Colorectal Cancer Surgical Treatments
- Lymphoma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Schizophrenia research and treatment
- Cancer Genomics and Diagnostics
- Electron Spin Resonance Studies
- Hereditary Neurological Disorders
- Cardiac tumors and thrombi
- Mental Health and Patient Involvement
- Electroconvulsive Therapy Studies
- Oral and Maxillofacial Pathology
- Reproductive Physiology in Livestock
- Veterinary Oncology Research
- Pancreatic and Hepatic Oncology Research
- Nitric Oxide and Endothelin Effects
- Mental Health Research Topics
- Intracranial Aneurysms: Treatment and Complications
- Colorectal Cancer Screening and Detection
- Ion Channels and Receptors
University of Bari Aldo Moro
2021-2025
Wansbeck General Hospital
2023-2024
Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari
2024
Scuola Internazionale Superiore di Studi Avanzati
2022-2023
University of Pisa
2023
Policlinico Tor Vergata
2015-2022
European Molecular Biology Laboratory
2018-2021
European Molecular Biology Organization
2020-2021
Heidelberg University
2019-2021
University of Pavia
2020
Epicardial fat density (EFD) is implicated in cardiovascular diseases. This study aimed to assess the regional variability of epicardial using coronary computed tomography (CCT) and evaluate feasibility ROI-based measurements as an alternative full segmentation. A retrospective analysis was conducted on 171 patients undergoing CCT. EFD measured non-contrast scans acquired globally three predefined regions interest (ROIs) for calcium scoring: aortic bulb, right posterolateral wall, cardiac...
This study aimed to assess the accuracy of Node-RADS scoring system in assessing metastatic lymph node (LN) involvement patients with head and neck squamous cell carcinoma (HNSCC), a critical factor for treatment planning prognosis. A retrospective analysis was conducted on 42 HNSCC who underwent preoperative MRI dissection. Two radiologists independently evaluated scans using system, results were compared postoperative histopathological findings. Sensitivity, specificity, positive...
Objectives: This study aimed to evaluate the diagnostic performance of various MRI sequences in detecting nodal metastasis (N+) and extranodal extension (ENE+) patients with head neck squamous cell carcinoma (HNSCC). Methods: A retrospective analysis was conducted on 42 HNSCC who underwent preoperative subsequent surgical lymph node dissection between June 2021 December 2023. Lymph features were evaluated five different sequences. For each rN+ case, presence radiological (rENE+) assessed...
To investigate pre-morbid, socio-demographic, clinical and cognitive variables as predictors of insight in a large representative sample first-episode psychosis patients.The abbreviated Scale to Assess Unawareness Mental Disorder was used assess dimensions. Patients with good poor were independently compared on dimensions logistic regression analyses conducted identify explanatory associated each dimension.The patients having mental disorder differed duration untreated psychosis, diagnosis...
The vasculature is innervated by a network of peripheral afferents that sense and regulate blood flow. Here, we describe system non-peptidergic sensory neurons with cell bodies in the spinal ganglia vascular tone distal arteries. We identify population mechanosensitive neurons, marked tropomyosin receptor kinase C (TrkC) tyrosine hydroxylase dorsal root ganglia, which projects to vessels. Local stimulation TrkC decreases vessel diameter flow, whereas systemic activation increases systolic...
Nerve growth factor (NGF) is a key mediator of nociception, acting during the development and differentiation dorsal root ganglion (DRG) neurons, on adult DRG neuron sensitization to painful stimuli. NGF also has central actions in brain, where it regulates phenotypic maintenance cholinergic neurons. The physiological function as pain altered patients with Hereditary Sensory Autonomic Neuropathy type V (HSAN V), caused by 661C>T transition Ngf gene, resulting R100W missense mutation...
The COVID-19 pandemic is inevitably changing the world in a dramatic way, and role of computed tomography (CT) scans can be pivotal for prognosis patients. Since start pandemic, great care has been given to relationship between interstitial pneumonia caused by infection onset thromboembolic phenomena. In this preliminary study, we collected n = 20 CT from Polyclinic Bari, all patients positive with COVID-19, nine which developed pulmonary thromboembolism (PTE). For eight scans, obtained...
Abstract Mechanically silent nociceptors are sensory afferents that insensitive to noxious mechanical stimuli under normal conditions but become sensitized such during inflammation. Using RNA-sequencing and quantitative RT-PCR we demonstrate inflammation upregulates the expression of transmembrane protein TMEM100 in electrophysiology revealed over-expression is required sufficient un-silence mice. Moreover, show mice lacking do not develop secondary hypersensitivity—i.e., pain...
The prognosis of colorectal cancer has continuously improved in recent years thanks to continuous progress both the therapeutic and diagnostic fields. specific objective this study is contribute field through evaluation correlation between superior hemorrhoidal vein (SHV) ectasia detected on computed tomography (CT) Tumor (T), Node (N), distant metastasis (M) examination mesorectal fascia (MRF) invasion preoperative staging rectal cancer.
Serum protein electrophoresis (SPE) reference intervals (RIs) have been evaluated in different horses, but no specific values are shown for equine breeds as previously described other species (dogs, cats), and studies performed on SPE draft horses.This study aimed to determine RIs heavy horses (Italian Heavy Draft Horse-IHDH) living central Italy. A comparison between physiologic states (pregnancy pregnancy) ages (foals adults) was executed.Blood samples were collected from 215 apparently...
Abstract Gene delivery using vector or viral-based methods is often limited by technical and safety barriers. A promising alternative that circumvents these shortcomings the direct of proteins into cells. Here we introduce a non-viral, ligand-mediated protein system capable selectively targeting primary skin cells in-vivo . Using orthologous self-labelling tags chemical cross-linkers, conjugate large to ligands bind their natural receptors on surface keratinocytes. Targeted CRE-mediated...
Summary Prosthetic laryngoplasty is a recognised treatment option for recurrent laryngeal neuropathy (RLN) in horses; however, there no report of the use alone or combination, as successful equine dysplasia. A 6‐year‐old Warmblood gelding was referred to hospital investigation respiratory noise and exercise intolerance. Grade 4 bilateral vocal fold collapse were diagnosed with overground endoscopy. Ultrasonography revealed The horse underwent standing laser ventriculectomy, left cordectomy,...
Pain is an unpleasant but necessary sensory experience, which facilitates adaptive behaviours, such as fear. Despite recent advances, the question of how pain experience influences learning fear response still debated 1,2 . Genetic disorders rendering patients congenitally unable to feel have been described, and are usually explained by defects in peripheral nociceptors 3-5 It not known growing up without affects central emotional motivational responses aversive stimuli. The rare autosomal...
Summary Silent nociceptors are sensory afferents that insensitive to noxious mechanical stimuli under normal conditions but become sensitized such during inflammation. Using RNA-sequencing and quantitative RT-PCR we demonstrate inflammation selectively upregulates the expression of transmembrane protein TMEM100 in silent electrophysiology revealed over-expression is required sufficient un-silence nociceptors. Moreover, show mice lacking do not develop secondary allodynia – i.e. pain...