A5012200468- Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Chronic Lymphocytic Leukemia Research
- Inflammatory Bowel Disease
- Hepatitis C virus research
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- Microscopic Colitis
- Hepatitis B Virus Studies
- Virus-based gene therapy research
- Cancer-related Molecular Pathways
- BRCA gene mutations in cancer
- PARP inhibition in cancer therapy
- Multiple Myeloma Research and Treatments
- Clostridium difficile and Clostridium perfringens research
- Genetic factors in colorectal cancer
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders
- Histone Deacetylase Inhibitors Research
- Platelet Disorders and Treatments
- Diagnosis and treatment of tuberculosis
- Neutropenia and Cancer Infections
European Institute of Oncology
2012-2024
University of Rome Tor Vergata
2019
Ripamonti
2018
University of Messina
2016
The ability of PRC1 and PRC2 to promote proliferation is a main feature that links polycomb (PcG) activity cancer. PcGs silence the expression tumour suppressor locus Ink4a/Arf, whose products positively regulate pRb p53 functions. Enhanced PcG frequent human tumours, inhibition has been proposed as strategy for cancer treatment. However, recurrent inactivation pRb/p53 responses in cancers raises question regarding proteins affect cellular independently from this checkpoint. Here we...
Abstract Background In a 6-year, multicenter, prospective nested case–control study, we aimed to evaluate risk factors for incident cancer in inflammatory bowel disease (IBD), when considering clinical characteristics of IBD and immunomodulator use. The secondary end point was provide characterization types. Methods All cases occurring patients from December 2011–2017 were prospectively recorded 16 Italian Group the Study Inflammatory Bowel Disease units. Each with new diagnosis matched 2...
The phosphatidylinositol 3 kinase (PI3K)-glycogen synthase β (GSK3β) axis plays a central role in MYC-driven lymphomagenesis, and MYC targeting with bromodomain extraterminal protein family inhibitors (BETi) is promising treatment strategy lymphoma. In high-throughput combinatorial drug screening experiment, BETi enhance the antiproliferative effects of PI3K panel diffuse large B cell lymphoma (DLBCL) Burkitt lines. or silencing upregulates several pathway genes induces GSK3β S9 inhibitory...
Background and Aims:Cancer risk in inflammatory bowel disease [IBD] is still debated. In a prospective, multicentre, nested case-control study, we aimed to characterise incident cases of cancer IBD. The role immunomodulators vs clinical characteristics IBD as factors for was also investigated.
Stem cell identity maintenance by PRC1 repressive activity is influenced TFs and epigenetic landscape of specific types.
The proteolytic cleavage of histone tails, also termed clipping, has been described as a mechanism for permanent removal post-translational modifications (PTMs) from proteins. Such activity ascribed to ensure regulatory function in key cellular processes such differentiation, senescence and transcriptional control, which different histone-specific proteases have described. However, all these studies were exclusively performed using cell lines cultured vitro no clear evidence that clipping is...
// Véronique Frattini 1,3 , Federica Pisati Maria Carmela Speranza Pietro Luigi Poliani 4 Gianmaria Frigé 3 Gabriele Cantini Dimos Kapetis 2 Manuela Cominelli Alessandra Rossi Gaetano Finocchiaro and Serena Pellegatta 1 Unit of Molecular Neuro-Oncology, Fondazione I.R.C.C.S. Istituto Neurologico C. Besta, Milan, Italy Service Bioinformatics, Department Experimental Oncology, European Institute Oncology - Campus IFOM-IEO, Pathology, University Brescia, Correspondence: Pellegatta, email:...
Leukemia is a complex heterogeneous disease often driven by the expression of oncogenic fusion proteins with different molecular and biochemical properties. Whereas several induce leukemogenesis activating Hox gene (Hox-activating fusions), others impinge on pathways that do not involve activation genes (non-Hox-activating fusions). It has been postulated one main properties HOXA9 transcription factor its ability to control p16/p19 tumor suppressor locus (Cdkn2a), thereby compensating...
Abstract Standard chemotherapies for diffuse large B-cell lymphoma (DLBCL), based on the induction of exogenous DNA damage and oxidative stress, are often less effective in presence increased MYC BCL-2 levels, especially case double hit (DH) lymphomas harboring rearrangements oncogenes, which enrich a patient’s population characterized by refractoriness to anthracycline-based chemotherapy. Here we hypothesized that adaptive mechanisms MYC-induced replicative consisting response (DDR)...
Noninvasive methods are useful for investigating patients with chronic HBV infection. The severity of liver disease in inactive HBsAg carriers can be noninvasively assessed by transient elastography (TE) alone or association biochemical markers fibrosis.The study evaluates the effectiveness TE compared to common fibrosis scores (FSs), APRI, Forns Index, and FIB4, identifying significant Italian foreigner carriers. To investigate risk progression disease, stiffness (LS) HBV-DNA were monitored...
Topic: 3. Acute myeloid leukemia - Biology & Translational Research Background: The introduction of the BCL-2 inhibitor Venetoclax (VEN) in combination with chemotherapy or hypomethylating agents (HMA) represents a major advancement Myeloid Leukemia (AML) therapy. However, VEN resistance is still an unmet clinical need. In this light, pharmacological disruption mitochondrial respiratory chain promising strategy to circumvent resistance. Tigecycline (Tig) and Linezolid (Lin), two antibiotics...